The new composition of circulating microvesicles: optimized protocols and reassessment of their characteristics and physiological functions [0.03%]
循环微囊的新组成：优化的协议及其特征和生理功能的再评估
Chen Zhang,Jiajia Hu,Yifan Shi et al.
Chen Zhang et al.
Microvesicles (MVs) have convenient clinical applications and play functional roles in cellular signal transduction. Although the clinical importance of MVs is being increasingly recognized, the current diversity of isolated protocols resul...
Reprogramming aging: genetically enhanced mesenchymal progenitor cells show systemic rejuvenation in primates [0.03%]
重编程衰老：遗传增强的间充质祖细胞在灵长类动物中表现出系统年轻化
Hongkun Wang,Yuanyuan Du
Hongkun Wang
Human iPSC-derived self-assembled cardiac organoids for evaluating drug developmental cardiotoxicity [0.03%]
人诱导多能干细胞来源的心肌器官芯片技术评估药物心脏毒性风险
Yi Xiao,Pengfei Xu,Jinmiao Bi et al.
Yi Xiao et al.
Haim Y Cohen,Vera Gorbunova,Steve Horvath et al.
Haim Y Cohen et al.
Jiyu Chen,Chang Liu,Yongqin Yu et al.
Jiyu Chen et al.
Adult ovarian tissues or biopsies isolated from patients prior to chemotherapy or irradiation can reconstitute ovarian functions when transplanted either in the abdomen or subcutaneously. Subcutaneously transplantation avoids invasive surge...
Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases [0.03%]
造血和骨髓生态位在炎症和非血液系统疾病中的作用
Yu-Xiang Wang,Zhao-Hua Deng,Yu-Yan Li et al.
Yu-Xiang Wang et al.
Hematopoiesis and the behavior of hematopoietic stem and progenitor cells (HSPCs) are regulated by the bone marrow niche. Here, we introduce the major niche cell types in bone marrow and their response to stress condition. We highlight the ...
Zixuan Hong,Yun Zhao,Sara Pahlavan et al.
Zixuan Hong et al.
Human pluripotent stem cells (hPSCs) hold great promise in regenerative medicine. However, immune rejections remain one of the major obstacles to stem cell therapy. Though conventional immunosuppressants are available in clinics, the side e...
Tcl1 coordinately promotes metabolic shift and regulates totipotency exit [0.03%]
TCPLE1通过协调代谢转换和调控全能性退出促进合子基因组激活
Xin Gao,Chen Gao,Yikai Shi et al.
Xin Gao et al.
During early embryonic development, particularly in the transition from totipotency to pluripotency, energy metabolism is closely linked to cell fate. However, the essential regulators of energy metabolism in this transition remain unclear....
Yunfei Qi,Xinheng He,Xiaoshan Wu et al.
Yunfei Qi et al.
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development [0.03%]
肠道类器官的应用和进展：肠病建模与治疗手段开发
Xiaoting Xu,Yuping Zhang,Guoxin Huang et al.
Xiaoting Xu et al.
Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological properties of the gut. These organoids serve as powerful tools for studying gut development and modeling...