Integrating GLP-1 receptor agonists with anti-amyloid immunotherapy for Alzheimer's disease: a phased clinical roadmap [0.03%]
GLP-1受体激动剂与抗淀粉样蛋白免疫疗法治疗阿尔茨海默病的联合策略：临床路线图构想
Junzhe Huang,Shengya Wang,Vincent C T Mok et al.
Junzhe Huang et al.
Life lies in movement [0.03%]
生命在于运动
Junzhu Yi,Yuanyuan Du
Junzhu Yi
A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium [0.03%]
关于脂肪组织衰老生物标志物的框架：衰老生物标志物研究联盟共识声明
Aging Biomarker Consortium;Jian Yu,Yankang Zhang,Ting Zhang et al.
Aging Biomarker Consortium;Jian Yu et al.
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue a...
Whole-process 3D ECM-encapsulated organoid-based automated high-throughput screening platform accelerates drug discovery for rare diseases [0.03%]
全过程中三维ECM封装类器官的自动化高通量筛选平台加速罕见病药物发现
Zhaoting Xu,Hui Yang,Yuru Zhou et al.
Zhaoting Xu et al.
Organoid-based high-throughput screening (HTS) is revolutionizing pharmaceutical development. However, the complexity of handling extracellular matrix (ECM) components with traditional HTS devices leads to the use of suspension cultures for...
Juanhong Liu,Qinlei Huang,Feng Liu
Juanhong Liu
Once viewed primarily as an energy reservoir, adipose tissue (AT) is now recognized as a key endocrinal organ in regulating systemic aging. With age, AT undergoes significant remodeling, marked by altered fat distribution, visceral fat expa...
Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation [0.03%]
溶菌酶通过调节促炎因子和NF-κB活化来缓解DSS诱导的结肠炎
Kai Wang,Lan Guo,Ting Wang et al.
Kai Wang et al.
Zhejun Ji,Guang-Hui Liu,Jing Qu
Zhejun Ji
Mitochondrial dysfunction is a hallmark of aging, characterized by a decline in mitochondrial biogenesis and quality control, compromised membrane integrity, elevated ROS production, damaged mitochondrial DNA (mtDNA), impaired mitochondrial...
A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium [0.03%]
视觉系统老化生物标志物框架：老龄化生物标志物联盟共识声明
Aging Biomarker Consortium;Chao Ma,Boxin Geng,Yangqing Zhang et al.
Aging Biomarker Consortium;Chao Ma et al.
The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decl...