Iron metabolism disorder promotes postovulatory oocyte aging by inducing oxidative stress damage [0.03%]
铁代谢紊乱通过诱导氧化应激损伤促进卵母细胞老化
Ziqi Huang,Bicheng Wang,Ying Tian et al.
Ziqi Huang et al.
Reactive oxygen species (ROS) involve in oocyte postovulatory aging, yet the mechanism of ROS accumulation is not fully understood. We explored iron metabolic status and its relationship with ROS in mouse oocytes during postovulatory aging ...
deepBlastoid: a deep learning model for automated and efficient evaluation of human blastoids [0.03%]
深度Blastoid：一种自动化且高效的评估人blastoids的深度学习模型
Zejun Fan,Zhenyu Li,Yiqing Jin et al.
Zejun Fan et al.
Recent advances in human blastoids have opened new avenues for modeling early human development and implantation. Human blastoids can be generated in large numbers, making them well-suited for high-throughput screening. However, automated m...
Integrating GLP-1 receptor agonists with anti-amyloid immunotherapy for Alzheimer's disease: a phased clinical roadmap [0.03%]
GLP-1受体激动剂与抗淀粉样蛋白免疫疗法治疗阿尔茨海默病的联合策略：临床路线图构想
Junzhe Huang,Shengya Wang,Vincent C T Mok et al.
Junzhe Huang et al.
Life lies in movement [0.03%]
生命在于运动
Junzhu Yi,Yuanyuan Du
Junzhu Yi
A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium [0.03%]
关于脂肪组织衰老生物标志物的框架：衰老生物标志物研究联盟共识声明
Aging Biomarker Consortium;Jian Yu,Yankang Zhang,Ting Zhang et al.
Aging Biomarker Consortium;Jian Yu et al.
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue a...
Whole-process 3D ECM-encapsulated organoid-based automated high-throughput screening platform accelerates drug discovery for rare diseases [0.03%]
全过程中三维ECM封装类器官的自动化高通量筛选平台加速罕见病药物发现
Zhaoting Xu,Hui Yang,Yuru Zhou et al.
Zhaoting Xu et al.
Organoid-based high-throughput screening (HTS) is revolutionizing pharmaceutical development. However, the complexity of handling extracellular matrix (ECM) components with traditional HTS devices leads to the use of suspension cultures for...
Juanhong Liu,Qinlei Huang,Feng Liu
Juanhong Liu
Once viewed primarily as an energy reservoir, adipose tissue (AT) is now recognized as a key endocrinal organ in regulating systemic aging. With age, AT undergoes significant remodeling, marked by altered fat distribution, visceral fat expa...