SIRT5 mitigates metabolic abnormality in murine models of metabolic dysfunction-associated steatotic liver disease [0.03%]
SIRT5可通过改善代谢异常来缓解小鼠与代谢功能障碍相关脂肪肝病的发展恶化
Min Xiao,Juncheng Zhao,Zixuan Dou et al.
Min Xiao et al.
Histidine phosphorylation of NME1 regulates the Hippo pathway via the ARHGAP17-CDC42-cytoskeleton axis [0.03%]
组氨酸磷酸化NME1通过ARHGAP17-CDC42-细胞骨架轴调控Hippo信号通路
Xian Liu,Zhongnan Chen,Jianxi Zhu et al.
Xian Liu et al.
NME1 is a key metastasis suppressor whose activity depends on histidine phosphorylation, yet the biological significance of this modification remains poorly understood. Here, we reveal a previously unrecognized role for NME1 in regulating t...
Liver regeneration: cytokine regulation targeting hepatocytes and beyond [0.03%]
肝再生：细胞因子调节作用不仅针对肝细胞
Ting Xiao,Zhangliu Jin,Jiangming Deng et al.
Ting Xiao et al.
The liver, the largest glandular organ in humans, exhibits a unique and robust regenerative capacity following injury. This regenerative response is orchestrated through a highly regulated network of cellular and molecular signals. Here, we...
New paradigm for aging research: aging studies through innovative AI applications and interdisciplinary collaborations [0.03%]
老龄化研究新范式——创新人工智能应用及跨学科合作推动衰老研究
Zeyu Gao,Mei Li,Jingyi Li et al.
Zeyu Gao et al.
Genetically engineered senescence-resistant human mesenchymal progenitor cells promote spinal cord injury repair [0.03%]
基因工程抗衰老人类间充质干细胞促进脊髓损伤修复
Taixin Ning,Jinghui Lei,Xiaoyu Jiang et al.
Taixin Ning et al.
Spinal cord injury (SCI) is a devastating condition affecting the central nervous system, often leading to persistent neurological dysfunction. While mesenchymal progenitor cells (MPCs) hold considerable promise for treating various disorde...
Senescent B cells regulate CD38 expression via FOXO1 in pneumonia resulting from PIK3CD (R437C) mutations [0.03%]
PIK3CD(R437C)基因突变导致的肺炎中衰老B细胞通过FOXO1调控CD38表达
Ju Liu,Yuxin Bai,Jianing Tang et al.
Ju Liu et al.
Activated phosphoinositide 3-kinase delta syndrome (APDS) is a primary immunodeficiency characterized by hyperactivated lymphocytes and recurrent infections. This study presents a 2.5-year-old patient with a novel PIK3CD gene mutation (c.13...
Dual-modality theranostics probes: sintegrative strategies for precision management of oncologic malignancies [0.03%]
诊疗一体化探针在恶性肿瘤精准管理中的整合策略
Xilin Jing,Yutao Li,Yijing Zhang et al.
Xilin Jing et al.
Cancer remains a formidable global public health challenge. Recent advancements in immunotherapy and targeted therapies have revolutionized diagnostic and therapeutic paradigms. Within this context, theranostics-an emerging field integratin...
Peripheral organ crosstalk in the regulation of ovarian endocrine function and reproductive homeostasis [0.03%]
外周器官在卵巢内分泌功能及生殖稳态调节中的对话作用
Lixuan Huang,Lei Xu,Chuyu Yun et al.
Lixuan Huang et al.
Ovarian function is increasingly recognized as a systemic process influenced by cross-organ communication, yet knowledge regarding the underlying mechanisms remains fragmented. In addition to the ovary, multiple organs, including the hypoth...
Integration of a novel anti-PD-1 antibody with chimeric antigen receptor-T engineered to express interleukin-7 enhances targeting efficacy against lung cancer [0.03%]
一种新型抗PD-1抗体与表达白细胞介素-7的嵌合抗原受体T细胞联合使用可提高肺癌靶向疗效
Chenxi Cheng,Lin Zhang,Jiani Cao et al.
Chenxi Cheng et al.
Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising approach for hematological malignancies, yet its efficacy in solid tumors is hindered by limited persistence. To address this, immune checkpoint inhibitors (ICIs) and...
Heterochronic parabiosis alters the transcriptomic landscape to combat aging and aging-related diseases in aging-accelerated mice [0.03%]
异时性亚甲连术改变转录组景观以对抗加速衰老小鼠的衰老及相关疾病
Haochen Wang,Wencong Lyu,Yuzhe Sun et al.
Haochen Wang et al.
Aging is a multifactorial process involving a gradual decline in cellular and tissue functions, making it a major risk factor for aging-related degenerative diseases. In this study, we utilized the senescence-accelerated mouse prone 8 mice ...