Baoguo Li,Yanxin Li,Zhongqiu Li et al.
Baoguo Li et al.
Neuron-periphery mitochondrial stress communication in aging and diseases [0.03%]
衰老和疾病条件下的神经元-周边组织线粒体应激信号转导
Jiasheng Li,Jimeng Cui,Ye Tian
Jiasheng Li
The nervous system is the central hub of the body, detecting environmental and internal stimuli to regulate organismal metabolism via communications to the peripheral tissues. Mitochondria play an essential role in neuronal activity by supp...
Peroxisome proliferator-activated receptor γ coactivator 1α maintains NAD+ bioavailability protecting against steatohepatitis [0.03%]
增生激活受体γ辅活化物1α维持核苷酸类辅助因子的生物有效性以对抗肝炎性肝病
Weiyan Shen,Xingyong Wan,Jiahui Hou et al.
Weiyan Shen et al.
Hepatic metabolic derangements are pivotal incidences in the occurrence of hepatic steatosis, inflammation, and fibrosis. Peroxisome proliferator-activated receptor-γ, coactivator-1α (PGC-1α), a master regulator that mediates adipose met...
Time-restricted eating on weight loss: implications from the TREATY study [0.03%]
限时饮食对体重减轻的影响——TREATY研究的启示
Yan Huang,Deying Liu,Xueyun Wei et al.
Yan Huang et al.
Tongtong Cui,Bojin Li,Wei Li
Tongtong Cui
Zhongyang Wu,Xu Zhou
Zhongyang Wu
Graphical Abstract. © The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.
Aging-associated accumulation of mitochondrial DNA mutations in tumor origin [0.03%]
与年龄相关的肿瘤起源线粒体DNA突变的积累
Minghua Kong,Lishu Guo,Weilin Xu et al.
Minghua Kong et al.
The majority of cancer patients are among aged population, suggesting an urgent need to advance our knowledge on complicated relationship between aging and cancer. It has been hypothesized that metabolic changes during aging could act as a ...
Chemical evocation of human cell plasticity-twist of cell fates by small molecules [0.03%]
化学诱导的人类细胞可塑性-小分子重塑细胞命运
Ge Liu,Jidong Fu,Nan Cao
Ge Liu
Comparative functional RNA editomes of neural differentiation from human PSCs [0.03%]
人类多能干细胞神经分化过程中的比较功能RNA编辑谱系分析
Yu Zhang,Qu Zhang,Yuhong Hou et al.
Yu Zhang et al.
RNA editing is a fundamental mechanism that constitutes the epitranscriptomic complexity. A-to-G editing is the predominant type catalyzed by ADAR1 and ADAR2 in human. Using a CRISPR/Cas9 approach to knockout ADAR1/2, we identified a regula...
Lingyan Xu,Yu Li,Toren Finkel et al.
Lingyan Xu et al.