Bone morphogenetic protein 7 derived from DPP4+ cells in beige fat ameliorates age-associated metabolic dysfunction [0.03%]
骨形态发生蛋白7由米色脂肪中的DPP4+细胞分泌，可改善年龄相关的代谢紊乱现象
Mingwei Guo,Jun Zhang,Ying Ma et al.
Mingwei Guo et al.
Baohu Zhang,Haoteng Yan,Xiaoqian Liu et al.
Baohu Zhang et al.
Fei Zhu,Guangjun Nie,Changsheng Liu
Fei Zhu
Stem cell-based regenerative therapies, which harness the self-renewal and differentiation properties of stem cells, have been in the spotlight due to their widespread applications in treating degenerative, aging, and other, generally intra...
Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m6A loss [0.03%]
来自重度溃疡性结肠炎的结肠干细胞通过改变染色质可及性和全局m6A丢失维持环境独立的免疫活化
Chuandong Liu,Jie Li,Hua Jin et al.
Chuandong Liu et al.
Ulcerative colitis (UC) is a chronic inflammatory disease of colon, which is characterized by cryptarchitectural distortion. Alternation of colonic stem cell (CoSC) contributed to the occurrence of UC, yet the regulatory mechanisms remain u...
Sugt1 loss in skeletal muscle stem cells impairs muscle regeneration and causes premature muscle aging [0.03%]
骨骼肌干细胞中Sugt1损失损害肌肉再生并引起肌肉早衰
Zhiming He,Xiaona Chen,Gexin Liu et al.
Zhiming He et al.
Adult skeletal muscle stem cells (MuSCs) are essential for muscle homeostasis and regeneration. During aging, the number of MuSCs and their regenerative capacity gradually decline but the underlying mechanisms remain elusive. Here, we ident...
Novel single-cell mtDNA sequencing technology reveals hidden mutations in oocytes, blastoids, and stem cells [0.03%]
新型单细胞线粒体DNA测序技术揭示卵母细胞、胚胞和干细胞中的隐性突变
Ismail M Shakir,Mo Li
Ismail M Shakir
A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency [0.03%]
基于CRISPR / Cas9的激酶组筛选鉴定ErbB信号是人类原始态多能性和全能性的一个新调节因子
Jiayu Li,Xiwen Lin,Liangfu Xie et al.
Jiayu Li et al.
Regulation of totipotency and naïve pluripotency is crucial for early human embryo development. However, the mechanisms of naïve pluripotency and totipotency regulation in humans, especially the signaling pathways involved in these proces...
GlycoRNAs: more than the intersection of glycobiology and RNA biology [0.03%]
糖基RNA：不仅仅是糖生物学和RNA生物学的交集
Haidong Li,Ruijin Zhang,Runsheng Chen et al.
Haidong Li et al.
The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility across rodents, monkeys, and humans [0.03%]
横跨啮齿目、灵长目和人类的卵巢间质细胞转录组及染色体可接近性特征演化研究
Qiancheng Zhang,Fengyuan Sun,Ruifeng Zhang et al.
Qiancheng Zhang et al.
The ovary plays a crucial role in the reproductive system of female mammals by producing mature oocytes through folliculogenesis. Non-human model organisms are extensively utilized in research on human ovarian biology, thus necessitating th...
Intestinal stem cells in intestinal homeostasis and colorectal tumorigenesis [0.03%]
肠干细胞在肠道稳态和结直肠肿瘤发生中的作用
Gaoli Shi,Yang Li,Haihong Shen et al.
Gaoli Shi et al.
Colorectal cancer (CRC), one of the most common tumors in the world, is generally proposed to be generated from intestinal stem cells (ISCs). Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5)-positive ISCs are located at th...