Zheng Hu,Minghui Fang,Fei Xu et al.
Zheng Hu et al.
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence [0.03%]
生物钟因子CLOCK和BMAL1促进非同源末端连接并抑制细胞衰老
Yu Chen,Xiaoyu Xu,Zhixi Chen et al.
Yu Chen et al.
Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency [0.03%]
DAZL截短型突变通过减少原始生殖细胞中NANOS3的表达而导致卵巢早衰
Qingyuan Liu,Ting Guo,An Yan et al.
Qingyuan Liu et al.
Bridging the organoid translational gap: integrating standardization and micropatterning for drug screening in clinical and pharmaceutical medicine [0.03%]
类器官转化差距的弥合：在临床和制药医学药物筛选中整合标准化和微图案化技术
Haowei Yang,Jiawei Li,Zitian Wang et al.
Haowei Yang et al.
Synthetic organ models such as organoids and organ-on-a-chip have been receiving recognition from administrative agencies. Despite the proven success of organoids in predicting drug efficacy on laboratory scales, their translational advance...
Cellular senescence induced by down-regulation of PTBP1 correlates with exon skipping of mitochondrial-related gene NDUFV3 [0.03%]
PTBP1表达沉默诱导的细胞衰老与线粒体相关基因NDUFV3外显子剪切有关
Yu Yang,Haimei Wen,Yuxin Li et al.
Yu Yang et al.
As the most prevalent type of alternative splicing in animal cells, exon skipping plays an important role in expanding the diversity of transcriptome and proteome, thereby participating in the regulation of diverse physiological and patholo...
Qi Chen,Pan-Deng Shi,Cheng-Feng Qin
Qi Chen
Mitochondrial transplantation for the treatment of cardiac and noncardiac diseases: mechanisms, prospective, and challenges [0.03%]
线粒体移植在心血管及非心血管系统疾病中的治疗作用：机制、前景与挑战
Xinyi Wang,Zhiyuan Liu,Ling Zhang et al.
Xinyi Wang et al.
Mitochondrial transplantation (MT) is a promising therapeutic strategy that involves introducing healthy mitochondria into damaged tissues to restore cellular function. This approach has shown promise in treating cardiac diseases, such as i...
Integration of single-cell transcriptome and chromatin accessibility and its application on tumor investigation [0.03%]
单细胞转录组和染色质可及性数据的整合及其肿瘤研究中的应用
Chunyuan Yang,Yan Jin,Yuxin Yin
Chunyuan Yang
The advent of single-cell sequencing techniques has not only revolutionized the investigation of biological processes but also significantly contributed to unraveling cellular heterogeneity at unprecedented levels. Among the various methods...
Wen Fang,Jiao Qu,Wanjun Zhao et al.
Wen Fang et al.
Awareness of estrogen's effects on health is broadening rapidly. The effects of long-term high levels of estrogen on the body involve multiple organs. Here, we used both single-cell chromatin accessibility and RNA sequencing data to analyze...
Yangfei Xiang,In-Hyun Park
Yangfei Xiang