Nestin prevents mesenchymal stromal cells from apoptosis in LPS-induced lung injury via inhibition of unfolded protein response sensor IRE1α [0.03%]
nestin通过抑制未折叠蛋白反应传感器IRE1α来防止骨髓间充质干细胞在LPS诱导的肺损伤中发生凋亡
Hongmiao Wang,Chenhao Jiang,Jianye Cai et al.
Hongmiao Wang et al.
The clinical applications of MSC therapy have been intensely investigated in acute respiratory distress syndrome. However, clinical studies have fallen short of expectations despite encouraging preclinical results. One of the key problems i...
Fat shapes fate: unlock the destiny of a cell with single-cell metabolomics [0.03%]
脂肪决定命运：利用单细胞代谢组学揭示细胞命运
Ziyi Wang,Fei Sun,Wei Xiong
Ziyi Wang
The natural product rotundic acid treats both aging and obesity by inhibiting PTP1B [0.03%]
轮档酸通过抑制PTP1B来同时治疗衰老和肥胖症
Jie Zhu,Yongpan An,Xin Wang et al.
Jie Zhu et al.
The occurrence of obesity is associated with age. But their interplay remains mysterious. Here, we discovered that rotundic acid (RA), a plant-derived pentacyclic triterpene, was a powerful agent for both anti-aging and treating obesity. Co...
Zheng Hu,Minghui Fang,Fei Xu et al.
Zheng Hu et al.
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence [0.03%]
生物钟因子CLOCK和BMAL1促进非同源末端连接并抑制细胞衰老
Yu Chen,Xiaoyu Xu,Zhixi Chen et al.
Yu Chen et al.
Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency [0.03%]
DAZL截短型突变通过减少原始生殖细胞中NANOS3的表达而导致卵巢早衰
Qingyuan Liu,Ting Guo,An Yan et al.
Qingyuan Liu et al.
Bridging the organoid translational gap: integrating standardization and micropatterning for drug screening in clinical and pharmaceutical medicine [0.03%]
类器官转化差距的弥合：在临床和制药医学药物筛选中整合标准化和微图案化技术
Haowei Yang,Jiawei Li,Zitian Wang et al.
Haowei Yang et al.
Synthetic organ models such as organoids and organ-on-a-chip have been receiving recognition from administrative agencies. Despite the proven success of organoids in predicting drug efficacy on laboratory scales, their translational advance...
Cellular senescence induced by down-regulation of PTBP1 correlates with exon skipping of mitochondrial-related gene NDUFV3 [0.03%]
PTBP1表达沉默诱导的细胞衰老与线粒体相关基因NDUFV3外显子剪切有关
Yu Yang,Haimei Wen,Yuxin Li et al.
Yu Yang et al.
As the most prevalent type of alternative splicing in animal cells, exon skipping plays an important role in expanding the diversity of transcriptome and proteome, thereby participating in the regulation of diverse physiological and patholo...
Qi Chen,Pan-Deng Shi,Cheng-Feng Qin
Qi Chen
Mitochondrial transplantation for the treatment of cardiac and noncardiac diseases: mechanisms, prospective, and challenges [0.03%]
线粒体移植在心血管及非心血管系统疾病中的治疗作用：机制、前景与挑战
Xinyi Wang,Zhiyuan Liu,Ling Zhang et al.
Xinyi Wang et al.
Mitochondrial transplantation (MT) is a promising therapeutic strategy that involves introducing healthy mitochondria into damaged tissues to restore cellular function. This approach has shown promise in treating cardiac diseases, such as i...