Tingting Zhou,Musunuru Kiran,Kathy O Lui et al.
Tingting Zhou et al.
Liver fibrogenesis is a highly dynamic and complex process that drives the progression of chronic liver disease toward liver failure and end-stage liver diseases. Despite decades of intense studies, the cellular and molecular mechanisms und...
The secret of youth: how is systemic rejuvenation achieved at the single cell level? [0.03%]
青春奥秘：单细胞水平的全身年轻化如何实现？
Lingna Wang,Jiaqing Liu,Huicong Liu et al.
Lingna Wang et al.
Peripheral immune landscape and natural killer-like B cells in human Vogt-Koyanagi-Harada disease [0.03%]
人类 Vogt-小柳原田病的外周免疫特征及 NK 样 B 细胞
He Li,Lei Zhu,Xiuxing Liu et al.
He Li et al.
Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder threatening the eyesight. The pathogenic mechanisms and biomarkers reflecting disease severity and predicting treatment response require further exploration. Here, we perf...
Functional hepatobiliary organoids recapitulate liver development and reveal essential drivers of hepatobiliary cell fate determination [0.03%]
功能性肝胆管器官样结构再现肝脏发育并揭示肝胆细胞命运决定的驱动因素
Juan He,Haoyue Cui,Xiaohan Shi et al.
Juan He et al.
During liver development, hepatocytes, and cholangiocytes are concurrently differentiated from common liver progenitor cells and are assembled into hepatobiliary architecture to perform proper hepatic function. However, the generation of fu...
Yuefan Wang,Ng Shyh-Chang
Yuefan Wang
Yusheng Cai,Zhejun Ji,Si Wang et al.
Yusheng Cai et al.
Aging is a major risk factor for multiple diseases, including cardiovascular diseases, neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the dysregulation of stem cells and other differentiated cells, and the imp...
Control cell death by endosomal trafficking of proton transistor nanophotosensitizers [0.03%]
内吞体转运纳米光敏剂的质子晶体管控制细胞死亡
Binlong Chen,Qiang Zhang,Jinming Gao et al.
Binlong Chen et al.
Nestin prevents mesenchymal stromal cells from apoptosis in LPS-induced lung injury via inhibition of unfolded protein response sensor IRE1α [0.03%]
nestin通过抑制未折叠蛋白反应传感器IRE1α来防止骨髓间充质干细胞在LPS诱导的肺损伤中发生凋亡
Hongmiao Wang,Chenhao Jiang,Jianye Cai et al.
Hongmiao Wang et al.
The clinical applications of MSC therapy have been intensely investigated in acute respiratory distress syndrome. However, clinical studies have fallen short of expectations despite encouraging preclinical results. One of the key problems i...
Fat shapes fate: unlock the destiny of a cell with single-cell metabolomics [0.03%]
脂肪决定命运：利用单细胞代谢组学揭示细胞命运
Ziyi Wang,Fei Sun,Wei Xiong
Ziyi Wang
The natural product rotundic acid treats both aging and obesity by inhibiting PTP1B [0.03%]
轮档酸通过抑制PTP1B来同时治疗衰老和肥胖症
Jie Zhu,Yongpan An,Xin Wang et al.
Jie Zhu et al.
The occurrence of obesity is associated with age. But their interplay remains mysterious. Here, we discovered that rotundic acid (RA), a plant-derived pentacyclic triterpene, was a powerful agent for both anti-aging and treating obesity. Co...