LoopID reveals condensate-mediated enhancer-promoter interaction regulates cell fate [0.03%]
环状DNA ID揭示冷凝物介导的增强子-启动子相互作用调控细胞命运决定
Shaoshuai Jiang,Lu Liu,Xinyi Liu et al.
Shaoshuai Jiang et al.
Zeming Wu,Shuai Ma,Si Wang et al.
Zeming Wu et al.
A growing body of evidence suggests that aging is not simply the accumulation of damage, but a systemic progression of increasing entropy across biological scales. Synthesizing concepts from thermodynamics and information theory, we outline...
TRIM22-mediated ubiquitin-dependent degradation of FLT3-ITD overcomes TKI resistance in acute myeloid leukemia [0.03%]
TRIM22介导的FLT3-ITD泛素依赖性降解可克服急性髓系白血病中的TKI耐药性
Meng Liu,Xiaoqian Wang,Xiaqin He et al.
Meng Liu et al.
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations, found in 25%-30% of acute myeloid leukemia (AML) patients, cause poor prognosis and resistance to FLT3 tyrosine kinase inhibitors (TKIs). We show that APG-115 sele...
Atypical involvement of Alzheimer's tau proteins in diseases beyond tauopathies [0.03%]
阿尔茨海默病tau蛋白在Tauopathy以外疾病中的非典型作用
Jie Meng,Zi-Jie Deng,Jing Zhang et al.
Jie Meng et al.
Tau is a microtubule-associated protein traditionally involved in a collective group of disorders termed "tauopathy", including Alzheimer's disease. Tau protein self-aggregates and forms neurofibrillary tangles in neurons, which are conside...
The metabolic change trajectory of skeletal muscle during the life cycle: arteriovenous metabolomics [0.03%]
骨骼肌生命周期代谢变化轨迹：动静脉代谢组学研究
Siyuan Huang,Yuanping Gu,Guogang Xu et al.
Siyuan Huang et al.
From metaphor to metric: the entropic framework as a unifying theory of aging [0.03%]
从隐喻到度量：熵框架作为统一的衰老理论
Yu Chen,Zhiyong Mao
Yu Chen
Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and therapeutic targets [0.03%]
肥胖症和精神障碍共有的遗传结构揭示了并存的病因学和治疗靶点
Dong Liu,Chun Dou,Chaojie Ye et al.
Dong Liu et al.
Integrated genomic evidence on shared genetic architecture between obesity and psychiatric disorders remains limited. This work utilized multi-level genomic analytic approaches to identify pleiotropic loci, variants, and genes between 14 ad...
HDAC8-selective inhibitor PCI-34051 protects against aortic dissection by attenuating ferroptosis of vascular smooth muscle cells [0.03%]
HDAC8特异性抑制剂PCI-34051通过减轻血管平滑肌细胞铁死亡保护小鼠免受主动脉夹层损害
Jiannan Ye,Juan Shi,Xin Yi et al.
Jiannan Ye et al.
Aortic dissection (AD) is a fatal emergency which lacks effective drug therapies. Previous studies demonstrated that histone deacetylase 8 (HDAC8) inhibition provides protective benefits in several cardiovascular diseases, including heart f...
The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy [0.03%]
从发病机制到精确诊疗的含羞草引起的口腔癌多步进展之路
Na Yu,Wenqiu Cai,Congyi Zhang et al.
Na Yu et al.
Areca nut is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. It is a widely consumed psychoactive substance with profound cultural roots in regions including Hunan, Hainan, and Taiwan of China. Its key...
Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice [0.03%]
儿童嗜酸细胞性食管炎唾液挥发性组分特征分析：临床实践中的无创性方法探索性研究
Rosamaria Capuano,Carla Petrella,Christian Barbato et al.
Rosamaria Capuano et al.
Eosinophilic esophagitis (EoE) is a chronic immune disease requiring repeated endoscopies for diagnosis and monitoring in children. Saliva represents a promising non-invasive biofluid, and volatile organic compounds (VOCs) may indicate dise...