Hui Zhang,Guang-Hui Liu,Jing Qu
Hui Zhang
SIRT1 deacetylates PKM2 to constrain lactate production and protect against premature ovarian insufficiency [0.03%]
SIRT1通过去乙酰化PKM2来限制乳酸产生并预防卵巢早衰
Xiangrong Cui,Chongyang Han,Puhua Zhang et al.
Xiangrong Cui et al.
Premature ovarian insufficiency (POI) causes early loss of ovarian function, though its underlying metabolic-epigenetic mechanisms remain unclear. Using ovarian tissues from POI patients and a cisplatin-induced mouse model, we investigated ...
Connexins in metabolic control: linking brain cellular communication to systemic homeostasis [0.03%]
代谢控制中的连接蛋白：从脑细胞通讯到全身稳态链接
Yiyi Zhu,Hui Chen,Dan Li et al.
Yiyi Zhu et al.
Connexins, a family of transmembrane proteins, are essential for intercellular communication in the mammalian central nervous system, particularly through their assembly into gap junction channels. This review explores the central role of c...
LoopID reveals condensate-mediated enhancer-promoter interaction regulates cell fate [0.03%]
环状DNA ID揭示冷凝物介导的增强子-启动子相互作用调控细胞命运决定
Shaoshuai Jiang,Lu Liu,Xinyi Liu et al.
Shaoshuai Jiang et al.
Zeming Wu,Shuai Ma,Si Wang et al.
Zeming Wu et al.
A growing body of evidence suggests that aging is not simply the accumulation of damage, but a systemic progression of increasing entropy across biological scales. Synthesizing concepts from thermodynamics and information theory, we outline...
TRIM22-mediated ubiquitin-dependent degradation of FLT3-ITD overcomes TKI resistance in acute myeloid leukemia [0.03%]
TRIM22介导的FLT3-ITD泛素依赖性降解可克服急性髓系白血病中的TKI耐药性
Meng Liu,Xiaoqian Wang,Xiaqin He et al.
Meng Liu et al.
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations, found in 25%-30% of acute myeloid leukemia (AML) patients, cause poor prognosis and resistance to FLT3 tyrosine kinase inhibitors (TKIs). We show that APG-115 sele...
Atypical involvement of Alzheimer's tau proteins in diseases beyond tauopathies [0.03%]
阿尔茨海默病tau蛋白在Tauopathy以外疾病中的非典型作用
Jie Meng,Zi-Jie Deng,Jing Zhang et al.
Jie Meng et al.
Tau is a microtubule-associated protein traditionally involved in a collective group of disorders termed "tauopathy", including Alzheimer's disease. Tau protein self-aggregates and forms neurofibrillary tangles in neurons, which are conside...
The metabolic change trajectory of skeletal muscle during the life cycle: arteriovenous metabolomics [0.03%]
骨骼肌生命周期代谢变化轨迹：动静脉代谢组学研究
Siyuan Huang,Yuanping Gu,Guogang Xu et al.
Siyuan Huang et al.
From metaphor to metric: the entropic framework as a unifying theory of aging [0.03%]
从隐喻到度量：熵框架作为统一的衰老理论
Yu Chen,Zhiyong Mao
Yu Chen
Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and therapeutic targets [0.03%]
肥胖症和精神障碍共有的遗传结构揭示了并存的病因学和治疗靶点
Dong Liu,Chun Dou,Chaojie Ye et al.
Dong Liu et al.
Integrated genomic evidence on shared genetic architecture between obesity and psychiatric disorders remains limited. This work utilized multi-level genomic analytic approaches to identify pleiotropic loci, variants, and genes between 14 ad...