Genetic heterogeneity in cardiovascular disease across ancestries: Insights for mechanisms and therapeutic intervention [0.03%]
跨祖先的心血管疾病遗传异质性：对发病机制和治疗干预的启示
Opeyemi Soremekun,Marie-Joe Dib,Skanda Rajasundaram et al.
Opeyemi Soremekun et al.
Cardiovascular diseases (CVDs) are complex in their aetiology, arising due to a combination of genetics, lifestyle and environmental factors. By nature of this complexity, different CVDs vary in their molecular mechanisms, clinical presenta...
Kelvin K F Tsoi,Pingping Jia,N Maritza Dowling et al.
Kelvin K F Tsoi et al.
More than 50 million older people worldwide are suffering from dementia, and this number is estimated to increase to 150 million by 2050. Greater caregiver burdens and financial impacts on the healthcare system are expected as we wait for a...
Mendelian randomization as a tool to inform drug development using human genetics [0.03%]
孟德尔随机化在利用人类遗传学信息指导药物开发方面的应用
Iyas Daghlas,Dipender Gill
Iyas Daghlas
Drug development is essential to the advancement of human health, however, the process is slow, costly, and at high risk of failure at all stages. A promising strategy for expediting and improving the probability of success in the drug deve...
Raffaella Casolino,Andrew V Biankin
Raffaella Casolino
Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed at an advanced, incurable, stage and has an extremely poor prognosis. Systemic chemotherapy represents the standard treatment either in the pre-operative, adjuvant and palliative ...
From precision medicine to precision care: Choosing and using precision medicine in the context of multimorbidity [0.03%]
从精准医疗到精准护理：多病共患情况下的精准医疗选择与应用
Arlene S Bierman,Bridget T Burke,Leeann N Comfort et al.
Arlene S Bierman et al.
Rapid advances in precision medicine promise dramatic reductions in morbidity and mortality for a growing array of conditions. To realize the benefits of precision medicine and minimize harm, it is necessary to address real-world challenges...
Paul Dimitri
Paul Dimitri
Medical practice is transforming from a reactive to a pro-active and preventive discipline that is underpinned by precision medicine. The advances in technologies in such fields as genomics, proteomics, metabolomics, transcriptomics and art...
Clinical translational research of liquid biopsy applications in prostate cancer and other urological cancers [0.03%]
液体活检在前列腺癌及其他泌尿系统肿瘤临床转化研究中的应用
Jingyi Huang,Da Huang,Xiaohao Ruan et al.
Jingyi Huang et al.
The aim of liquid biopsies is to obtain tumor information via the molecular interrogation of liquid samples, including blood and urine. As a minimally invasive procedure, liquid biopsies have attracted attention. A series of studies have re...
Clinical application of circulating cell-free lymphoma DNA for fast and precise diagnosis of Burkitt lymphoma: Precision medicine for sub-Saharan Africa [0.03%]
循环肿瘤DNA快速精准诊断 Burkitt 淋巴瘤的临床应用——面向非洲撒哈拉以南国家的精准医疗方案研究进展
Clara Chamba,Sam M Mbulaiteye,Emmanuel Balandya et al.
Clara Chamba et al.
Burkitt lymphoma (BL) has a cure rate of around 95% when treated with chemo-immunotherapy that is standard of care in high-income countries (Minard-Colin et al., 2020, New England Journal of Medicine 382, 2207-2219), but currently, more tha...
Optimizing human performance in extreme environments through precision medicine: From spaceflight to high-performance operations on Earth [0.03%]
通过精准医疗优化极端环境下的人类表现：从太空飞行到地球上的高性能运作
Michael A Schmidt,Jeffrey A Jones,Christopher E Mason
Michael A Schmidt
Humans operating in extreme environments often conduct their operations at the edges of the limits of human performance. Sometimes, they are required to push these limits to previously unattained levels. As a result, their margins for error...
UK biobank: Enhanced assessment of the epidemiology and long-term impact of coronavirus disease-2019 [0.03%]
英国生物样本库：增强对冠状病毒疾病-19流行病学和长期影响的评估
Qi Feng,Ben Lacey,Jelena Bešević et al.
Qi Feng et al.
UK Biobank is an intensively characterised prospective cohort of 500,000 adults aged 40-69 years when recruited between 2006 and 2010. The study was established to enable researchers worldwide to undertake health-related research in the pub...