A nationwide survey of infection prevention and control and high-level disinfection and sterilization practices in the Dominican Republic [0.03%]
多米尼加共和国感染预防控制及高水平消毒灭菌实践的全国调查
Elianet Castillo,Rita Rojas-Fermin,Claudia Blanco et al.
Elianet Castillo et al.
Healthcare-associated infections (HAIs) are often preventable and cause significant morbidity and mortality. There is a paucity of data on HAIs in low- and middle-income countries. This study surveyed Dominican Republic hospitals, revealing...
Clinical utility of plasma microbial cell-free DNA sequencing for early diagnosis of toxoplasmosis in high-risk patients: a five-patient case series [0.03%]
一种用于高风险患者弓形虫病早期诊断的临床检测方法：五例病例系列分析
Fernando H Centeno,Todd Lasco,Mayar Al Mohajer
Fernando H Centeno
From 2017 to 2025, we reviewed plasma microbial cell-free DNA sequencing (mcfDNA NGS) results detecting Toxoplasma gondii. Five patients were identified. Median turnaround was 3 days (2-5). mcfDNA initiated therapy in two and supported empi...
Emergency department urine culture stewardship and downstream outcomes: a covariate-adjusted biweekly interrupted time series analysis [0.03%]
急诊尿培养管理及后续影响：一种调整了协变量的双周中断时间序列分析
James Howard Acuff,Ashwini Gotimukul,Ganesh Srinivasan Krishnamurthi et al.
James Howard Acuff et al.
Background: Emergency department (ED) urine culture stewardship may reduce low-value testing, but downstream effects on antibiotic use and postdischarge utilization remain uncertain. ...
Assessing the impact of antimicrobial stewardship in low-income healthcare settings: a study of antibiotic use and antimicrobial susceptibility patterns in Indian hospitals [0.03%]
抗菌药物管理在低收入医疗环境中的影响评估：印度医院抗生素使用及抗菌模式研究
Ulhas Vasave,Amit Paroha
Ulhas Vasave
Objective: The rising incidence of antimicrobial resistance (AMR) underscores the urgent need for effective antimicrobial stewardship (AMS). This study assessed the impact of a tailored AMS initiative in Indian hospitals....
Assessment of treatment outcomes in patients receiving high- versus low-dose sulfamethoxazole-trimethoprim for oral stepdown therapy in gram-negative bacteremia: a multi-center, retrospective cohort study [0.03%]
一项多中心回顾性队列研究：高剂量和低剂量磺胺甲恶唑-甲氧苄啶作为革兰氏阴性菌血症的序贯治疗的效果评估
Jordan Jones,Rachel B Colven,Taylor Morrisette et al.
Jordan Jones et al.
Objective: Many studies have evaluated the safety and efficacy of oral stepdown therapy for treatment of gram-negative bacteremia (GNB). There are currently no studies comparing the safety and effectiveness of various dos...
Epidural anesthesia not associated with decreased 30-day surgical site infection occurrence after open colorectal surgery [0.03%]
术后腰硬联合麻醉与开腹结直肠手术后30天手术部位感染发生率降低无关
Matthew Smith,Jackson Prestwood,Krista Highland et al.
Matthew Smith et al.
Objective: Surgical site infections (SSI) after colorectal surgery are common. Epidural anesthesia (EA) has demonstrated multiple beneficial effects for patients undergoing open colorectal surgery. However, research regar...
Ambulatory antibiotic prescribing for acute sinusitis: a multicenter, retrospective cohort study evaluating appropriateness [0.03%]
关于急性副鼻窦炎门诊抗生素处方合理性的多中心回顾性队列研究
Kellie Arensman Hannan,Dan Ilges,Kimberly T Le et al.
Kellie Arensman Hannan et al.
Objective: Antibiotics are frequently prescribed for acute sinusitis despite national guidelines recommending antibiotics only if specific symptom criteria are met. We aimed to define the proportion of acute sinusitis enc...
A multifaceted antimicrobial stewardship intervention to improve antibiotic utilization and prescribing for sinusitis in a large primary care network [0.03%]
一项针对大型基层医疗网络鼻窦炎患者的多管齐下的抗菌药物管理干预措施改善抗生素的使用和处方抗生素
Mike Sportiello,Colin Samoriski,Christine Kim et al.
Mike Sportiello et al.
A quality improvement project was implemented across a large primary care network to decrease antibiotic use and improve guideline-concordant therapy for acute sinusitis. The multifaceted intervention included education, EHR decision suppor...
Entrustable professional activities: a roadmap for infectious diseases fellowship training in antibiotic stewardship [0.03%]
抗菌药物管理中的传染病专科医师培训路线图：可委派的职业活动方法
Reinaldo Perez,Molly McDonough,Eileen Maziarz et al.
Reinaldo Perez et al.
Infectious diseases fellowship programs for physicians seek to train the next generation of leaders in antimicrobial stewardship, but few published resources are available to guide educational experiences. As an adaptable tool for training ...
Optimizing antibiotic prophylaxis in the surgical setting of an ambulatory hospital for patients with penicillin allergy labels: a quality improvement initiative [0.03%]
门诊手术环境中针对青霉素过敏标签患者的抗菌药物预防质量改进项目优化措施
Cassandra Elias,Hazra Chowdhury,Rebecca Wright et al.
Cassandra Elias et al.
At a Canadian ambulatory hospital, a quasi-experimental quality improvement initiative evaluated penicillin-allergy education modules using pre-post surveys. Among 61 clinicians, Module 1 was not associated with change in penicillin allergy...