Cancer care disparities among patients with limited English proficiency: challenges and strategies for equity [0.03%]
英语有限的患者的癌症治疗差异：公平性的挑战与策略
Hye Sung Kim,Carly Irwin,Arjun S Ulag et al.
Hye Sung Kim et al.
As the population of individuals with limited English proficiency (LEP) continues to rise in the United States, language barriers have become an increasingly important yet underrecognized driver of disparities in cancer care. This review ai...
Somatic DICER1 pathogenic variants detected in a well-differentiated fetal lung adenocarcinoma diagnosed in a man with familial adenomatous polyposis [0.03%]
检测到索马特DICER1致病性变异体诊断出一例与家族性肠息肉病相关的胎儿型肺腺癌
Afrida Ahmed,Paul S Thorner,Anne-Laure Chong et al.
Afrida Ahmed et al.
Well-differentiated fetal lung adenocarcinoma (WDFLAC) is a rare pulmonary carcinoma characterized by its resemblance to fetal lung. It is thought to be caused by somatic pathogenic variants (PVs) in the genes CTNNB1 or APC, which lead to t...
Bone marrow evaluation in neuroblastomas: bone marrow aspirates have little additional value over trephine biopsies [0.03%]
神经母细胞瘤的骨髓评估：骨髓抽吸物的价值远低于活检结果
R S Bruinsma,A van Barneveld,B W Meussen et al.
R S Bruinsma et al.
Background: Bone marrow involvement is essential for staging, treatment evaluation, and progression/relapse detection in neuroblastoma patients. We investigated the diagnostic accuracy of trephine biopsies (TBs) and the a...
Transcriptome profiling of uterine leiomyosarcomas identifies a leiomyoma-like expression pattern that indicates better survival [0.03%]
子宫平滑肌肉瘤转录组谱型分析发现具有良性的肌瘤转录特征表示较好的预后
Sara Khamaiseh,Riitta Koivisto-Korander,Nora Schreiber et al.
Sara Khamaiseh et al.
Background: Uterine leiomyosarcomas are rare and aggressive cancers with poor survival. Their non-cancerous counterparts, uterine leiomyomas, are common tumors affecting many women during reproductive years. Distinguishin...
Justin Bessette,Jonathan Arditi,Julia Noreck et al.
Justin Bessette et al.
Background: Medical comorbidities are prevalent in the glioblastoma population, although their effects on survival are not well established. Methods: ...
KRAS and NRAS mutations in Nordic population-based and real-world metastatic colorectal cancer cohorts [0.03%]
北欧人群和真实世界转移性结直肠癌队列中的KRAS和NRAS突变
Emerik Osterlund,Ari Ristimäki,Luís Nunes et al.
Emerik Osterlund et al.
Background: KRAS and NRAS mutations (mt) are drivers in metastatic colorectal cancer (mCRC). We studied frequencies, characteristics, treatments, and outcomes of different KRASmt and NRASmt in population-based and real-wo...
The transcription factor Blimp-1 is suppressed by SLAMF1 and drives Treg cell-mediated immune evasion in non-small cell lung cancer [0.03%]
SLAMF1通过抑制转录因子Blimp-1介导的Treg细胞免疫逃逸促进非小细胞肺癌进展
Susetta Finotto,Denis I Trufa,Sonja Trump et al.
Susetta Finotto et al.
Background: Immune checkpoint inhibitors targeting the interaction between PD1 and PDL1 are effective for immunotherapy in non-small cell lung cancer (NSCLC). However, only subgroups of patients respond to therapy, sugges...
Stromal collagen IV expression and risk of breast cancer death in ductal carcinoma in situ [0.03%]
导管原位癌基质层IV型胶原表达与乳腺癌死亡风险的关系
Gunilla Rask,Malin Jansson,Johan Svensson et al.
Gunilla Rask et al.
Background: Current treatment for ductal carcinoma in situ (DCIS) of the breast is generic, due to lack of risk stratification tools. We investigate the correlation between expression of collagen IV in the breast and risk...
Too much or too little? The trajectory of systemic anti-cancer treatment throughout the last year of life of lung cancer patients in Norway [0.03%]
太多还是太少？过去一年中挪威肺癌患者的系统性抗癌治疗历程
Steinar Solberg,Kathinka Schmidt Slørdahl,Marianne Aanerud et al.
Steinar Solberg et al.
Background: The use of systemic anti-cancer treatment (SACT) at the end of life (EOL) is controversial. The evidence and detailed description of the dynamics of its use are deficient, especially after the introduction of ...
Germline JAK2 R564Q variants presenting as hereditary thrombocytosis: case report [0.03%]
遗传性血小板增多症的生殖系JAK2 R564Q变异：病例报告
Stephanie Franco,Kinga Krawiec,Piotr Strzalka et al.
Stephanie Franco et al.
Myeloproliferative neoplasms (MPNs) are classically attributed to somatic variants in JAK2, CALR, and MPL, with epidemiologic studies demonstrating an increased risk for MPNs within first-degree relatives. Germline variants associated with ...