Obesity, metformin prescription and risk of advanced prostate cancer in non-diabetic men [0.03%]
非糖尿病男性肥胖、二甲双胍处方与晚期前列腺癌发病风险的关系
Visalini Nair-Shalliker,Albert Bang,Rani Radhika-Chand et al.
Visalini Nair-Shalliker et al.
Background: The aim is to determine the effects of obesity and metformin-use in predicting prostate cancer (PC) risk. Methods: We used ...
Implementing mainstream germline genetic testing in breast cancer across Europe [0.03%]
在欧洲乳腺癌中实施主流生殖系基因检测
Eduard Pérez-Ballestero,Sagal Ahmed Shire,Mateja Krajc et al.
Eduard Pérez-Ballestero et al.
The implementation of mainstream germline genetic testing in breast cancer patients has both benefits and challenges. Multiple aspects need to be considered for the outline of gene panels and the amount of pre-test genetic counselling. Main...
Characterisation of adult patients with neuroendocrine neoplasms and their journey to diagnosis [0.03%]
神经内分泌肿瘤患者的特征及其诊断经历
Busani Ndlela,Ruth Swann,Georgios Lyratzopoulos et al.
Busani Ndlela et al.
Background: Neuroendocrine neoplasms (NENs) are rare and often present with non-specific symptoms. Diagnostic delays of 4 years or more have been reported in patient surveys, primarily attributed to low recognition of sym...
Ella Vallely,Catherine S Weadick,Teresa Treacy et al.
Ella Vallely et al.
Background: A previously conducted study reported that insomnia rates among oncology patients in Ireland are twice that of the general population, and that a breast cancer diagnosis was an independent predictor for clinic...
Dirk Hofmeister
Dirk Hofmeister
A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2 [0.03%]
BRCA1或BRCA2基因致病性突变男性和女性胰腺癌风险的前瞻性观察研究
Eli Marie Grindedal,Manuela Zucknick,Sigrid Tronsli Hovland et al.
Eli Marie Grindedal et al.
Background: BRCA1 and BRCA2 carriers have increased risk of pancreatic cancer (PC). We have studied prospective incidence rate and cumulative risk of PC in a large cohort of confirmed carriers. ...
'Is it my last Christmas?' Using real-world data as a prompt to reflect on goal-concordant advanced lung cancer care-a retrospective, longitudinal study [0.03%]
“这是我最后一个圣诞节吗？”使用现实世界的数据来反思晚期肺癌的协调目标护理——一项回顾性纵向研究
Clara Forrest,Julie Twomey,Mansoor Qayoumi et al.
Clara Forrest et al.
Objectives: Advanced non-small cell lung cancer (NSCLC) treatment paradigms include prolonged systemic anti-cancer therapy (SACT) courses. Treatment breaks during significant life events may align with patients' care goal...
Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and risk of lifestyle-related cancers in the prostate, lung, colorectal, and ovarian cancer screening trial [0.03%]
2018世界癌症研究基金会/美国癌症研究所癌症预防推荐依从性与前列腺、肺、结直肠和卵巢癌筛查试验对象患生活方式相关癌症风险的关系
Fiona C Malcomson,Marissa M Shams-White,Jill Reedy et al.
Fiona C Malcomson et al.
Background: The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations aim to lower cancer incidence. Our study explored associations between adherence to th...
Tumor cell-intrinsic PD-1 regulates chemotherapy resistance in colorectal cancer cells by activating downstream MAPK signaling [0.03%]
肿瘤细胞固有的PD-1通过激活下游MAPK信号转导调节结直肠癌的化疗耐药性
Ho Kit Mok,Sophie Sneddon,Jianhua Ren et al.
Ho Kit Mok et al.
Background: Colorectal cancer (CRC) remains a significant clinical challenge. Immunotherapy against programmed cell death 1 protein (PD-1) in CRC has limited success. Intriguingly, CRC cells express PD-1 (ciPD-1) intrinsi...
Introduction of whole genome sequencing as NHS standard of care for glioma patients in two neurosurgical oncology centres: West Midlands [0.03%]
全基因组测序作为英国国民保健制度胶质瘤患者的护理标准在两个神经外科肿瘤中心的实施：西米德兰郡
Victoria Wykes,Erminia Albanese,Vassili Crispi et al.
Victoria Wykes et al.
Background: The challenges of introducing Whole Genome Sequencing (WGS) as NHS standard of care for patients with glioma are reviewed. Methods: ...