Steven A Narod
Steven A Narod
Risk-based screening includes varying screening protocols for women based on their risk of breast cancer. The WISDOM trial incorporates universal genetic testing for nine susceptibility genes into risk assessment. Carriers of high-penetranc...
Obesity-associated gene mutations across cancer types: a pan-cancer analysis of TCGA data [0.03%]
肥胖相关基因在癌症类型中的变异泛癌分析：来自TCGA数据的证据
Gaetana Porcelli,Rosario Nicola Brancaccio,Sebastiano Di Bella et al.
Gaetana Porcelli et al.
Background: Obesity is a recognized risk factor for numerous cancers. Although several biological mechanisms have been proposed to explain obesity-associated carcinogenesis, the extent to which excess adiposity influences...
IL10RB expression in cancer cells is associated with evolutionary changes to solidify treatment resistance [0.03%]
癌症细胞中IL10RB的表达与巩固治疗抵抗性的表型变化有关
Chie Kudo-Saito,Hiroki Ozawa,Hiroshi Imazeki et al.
Chie Kudo-Saito et al.
Background: Many molecular mechanisms underlying tumor escape, in which cancer cells undergo epithelial-to-mesenchymal transition (EMT) and thereby acquire metastatic potential and cancer stemness, have been reported. How...
Understanding the preferences of younger women for the delivery of a service to predict breast cancer risk: a discrete choice experiment [0.03%]
了解年轻女性对提供乳腺癌风险预测服务偏好的选择实验研究
Stuart J Wright,Shabnam Thapa,Amber Salisbury et al.
Stuart J Wright et al.
Background: This study aimed to understand the preferences of a sample of younger women (30-39 years) for the attributes of models of service delivery for a breast cancer risk-prediction service to identify how best to de...
Patients' responses & reflections when receiving news of cancer progression: a qualitative study [0.03%]
癌症患者病情恶化时的反应和感悟——一项定性研究
Julia Ten Hove,Danielle Kain,Jacqueline Galica et al.
Julia Ten Hove et al.
Background: Limited literature exists characterizing the range of patient reactions during conversations about serious illnesses. This paper explores the variability of patients' responses when receiving bad news about th...
The COVID-19 pandemic has not influenced survival outcomes of head and neck cancer squamous cell carcinomas in the West of Scotland: a retrospective cohort study [0.03%]
新冠大流行未影响苏格兰西部头颈癌鳞状细胞癌的预后：一项基于回顾性队列的研究
Craig D L Smith,Alex D McMahon,Gareth J Inman et al.
Craig D L Smith et al.
Background: The COVID-19 pandemic posed significant disruptions to healthcare worldwide. This study aimed to assess if the COVID-19 pandemic affected short-term survival outcomes of patients with head and neck cancer squa...
Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis [0.03%]
肿瘤恶病质小鼠的内源大麻素系统介质水平变化：与脂肪变性和肠道微生物群紊乱的关系
Alexandra L Degraeve,Adele Cutignano,Fabiana Piscitelli et al.
Alexandra L Degraeve et al.
Background: Cachexia is a debilitating syndrome associated with involuntary weight loss, often occurring in cancer patients. In both humans and animal models, alterations in endocannabinoid (eCB) signaling occur in associ...
Victoria Sopik,Jan Lubiński,Jacek Gronwald et al.
Victoria Sopik et al.
Background: There is large variation in case-fatality rates of breast cancer in young women across the world. The objective of this study was to estimate the ten-year overall survival of women diagnosed with breast cancer...
Cosegregation analysis following an excellent response to olaparib in a pancreatic cancer patient carrier of BRCA2:c.7892 T > C variant enables its reclassification from VUS to pathogenic [0.03%]
一位携带BRCA2:c.7892T>C变异的胰腺癌患者在使用奥拉帕利后获得良好疗效，使该变异从VUS重新分类为致病型的 cosegregation 分析
Ksenija Strojnik,Ana Blatnik,Mateja Krajc et al.
Ksenija Strojnik et al.
Identification of variants of uncertain significance (VUS) presents a great challenge in oncogenetics, especially in the era of personalised cancer treatment. We present a metastatic pancreatic cancer patient, referred for predictive geneti...
STAR (stroma-tumor AI risk) assessment: association of AI-derived tumor-stroma proportion with patient survival provides added prognostic value beyond KELIM in epithelial ovarian cancer [0.03%]
星评（间质-肿瘤AI风险）评估：基于人工智能的肿瘤间质比例与患者生存的关系为上皮性卵巢癌的预后提供了超越KELIM的价值
Arpit Aggarwal,Morgann Madill,Mayukhmala Jana et al.
Arpit Aggarwal et al.
Background: There remains a critical need for prognostic biomarkers of treatment response in epithelial ovarian cancer (EOC). The KELIM score, derived from the rate of CA-125 elimination during the first 100 days of treat...