4-weekly avelumab plus axitinib in patients with metastatic renal cell carcinoma [0.03%]
卡博替尼联合阿维鲁单抗治疗晚期肾细胞癌患者的一项4周研究
Naveen S Vasudev,Umair Aleem,Kathryn Humphries et al.
Naveen S Vasudev et al.
Background: 800 mg avelumab, given every 2 weeks, in combination with axitinib, is an approved first-line treatment option for patients with metastatic renal cell carcinoma (mRCC). Less frequent administration of avelumab...
Ibraheem Alshareedah,James D Brunner,Patrick S G Chain et al.
Ibraheem Alshareedah et al.
Cancer is the leading cause of death around the world. While some types of cancer have become manageable due to advancements in medicine, most cancers still lack available cures and treatments. Recent studies have shown that changes in the ...
Disparities in blood cancer survival in the UK 2009-2019: national cohort studies [0.03%]
英国2009-2019年血液系统癌症生存率的差异：全国队列研究
Janice Hoang,Joshua Allen,Rebecca Capel et al.
Janice Hoang et al.
Abstarct: BACKGROUND: Blood cancers are among the most common and deadliest in the UK, affecting over 40,000 people annually. Survival varies by subtype, but this is not routinely reported for the UK. This study estimated...
Precision oncology in the age of AI: lessons from AI-driven drug discovery and clinical translation [0.03%]
人工智能时代精准肿瘤学的发展：来自人工智能驱动的药物发现和临床转化的启示
Wonbeak Yoo
Wonbeak Yoo
Drug discovery has been constrained by extended timelines and high costs, as the cumulative requirements of preclinical validation, multi-phase clinical trials, and regulatory approval have been imposed. Recently, computational modeling has...
Remarkable response of metaplastic breast cancer to a novel targeted AKT inhibitor TAS-117 in a Cowden syndrome patient: a case report [0.03%]
高酪氨酸血症综合征患者的新型靶向AKT抑制剂TAS-117治疗代谢性乳腺癌的显著疗效：个案报告
Eva Godina,Marta Fernández Carcaño,Burak Uzunparmak et al.
Eva Godina et al.
PTEN hamartoma tumour syndrome (PHTS) is characterized by a germline PTEN mutation and a substantial increase in lifetime breast cancer risk to 85% with lower age at first diagnosis. Despite the availability of agents targeting PTEN-regulat...
High expression of the ADC target Claudin-6 associates with aggressive endometrial cancer and remains high in metastatic lesions [0.03%]
Claudin-6高表达与子宫内膜癌的侵袭性相关并在转移灶中持续高表达
Vilde Linnea Gullovsen,Daniela Pavlicenco,Marta E Hjelmeland et al.
Vilde Linnea Gullovsen et al.
Background: Patients with advanced or recurrent endometrial cancer (EC) have limited treatment options. The development of antibody-drug conjugates (ADCs) offers new treatment strategies by targeted delivery of cytotoxic ...
Molecular targeting of the meningioma cell signaling circuit reveals drug vulnerabilities including synergy between sulforaphane and focal adhesion kinase inhibition [0.03%]
靶向脑膜瘤细胞信号通路的分子研究发现药物作用靶点包括萝卜硫素与焦黏附蛋白激酶抑制之间的协同作用
Michelle C Schwab,Yasmin Kocas,Sarah Gendreizig et al.
Michelle C Schwab et al.
Background: Meningiomas represent a common type of brain tumours and arise from the arachnoid cap cells which line the dural coverings of the brain. These predominantly benign tumours cause strong morbidity due to their i...
Steven A Narod
Steven A Narod
In the COMET study of women with DCIS, surgery done at the time of diagnosis did not reduce the subsequent incidence of invasive cancer at two years, compared to a ‘watchful-waiting’ approach. This leads us to re-think the conventional vi...
A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair-deficient breast or ovarian cancer [0.03%]
一种全面的基因组框架 用于识别易患同源重组修复缺陷型乳腺癌或卵巢癌的基因
José Camacho-Valenzuela,Thibaut Matis,Carla Roca et al.
José Camacho-Valenzuela et al.
Background: Patients with clinical characteristics of increased cancer susceptibility without an identified genetic lesion are regularly seen in clinics. Association studies and matched normal/tumour sequencing have advan...
Correction: Cosegregation analysis following an excellent response to olaparib in a pancreatic cancer patient carrier of BRCA2:c.7892 T > C variant enables its reclassification from VUS to pathogenic [0.03%]
纠正：奥拉帕利对BRCA2:c.7892T>C变异体携带者胰腺癌患者的优秀疗效使得该基因型从VUS重新分类为致病型的相关系谱分析
Ksenija Strojnik,Ana Blatnik,Mateja Krajc et al.
Ksenija Strojnik et al.
Published Erratum
BJC reports. 2026 Apr 2;4(1):14. DOI:10.1038/s44276-026-00217-x 2026