A novel colorectal cancer test combining microsatellite instability and BRAF/RAS analysis: Clinical validation and impact on Lynch syndrome screening [0.03%]
结合微卫星不稳定性和BRAF/RAS分析的新型结直肠癌检测方法：临床验证及对林奇综合征筛查的影响
Richard Gallon,Patricia Herrero-Belmonte,Rachel Phelps et al.
Richard Gallon et al.
Background: Lynch syndrome (LS) is under-diagnosed. UK National Institute for Health and Care Excellence guidelines recommend multistep molecular testing of all colorectal cancers (CRCs) to screen for LS. However, the com...
Small extracellular vesicles in plasma carry luminal cytokines that remain undetectable by antibody-based assays in cancer patients and healthy donors [0.03%]
血浆中微小胞外囊泡携带的细胞因子在癌症患者和健康供者中通过基于抗体的方法无法检测到
Chang Sook Hong,Brenda Diergaarde,Theresa L Whiteside
Chang Sook Hong
Background: Small (30-150nm) extracellular vesicles (sEV), also known as exosomes, play a key role in cell-to-cell signaling. They are produced by all cells, circulate freely and are present in all body fluids. Evidence i...
Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease [0.03%]
233个结直肠癌易感位点与1926例晚期结直肠癌患者生存期之间的关系研究
Christopher Wills,Amy Houseman,Katie Watts et al.
Christopher Wills et al.
Background: Genome, transcriptome and methylome-wide association studies have identified single-nucleotide polymorphisms (SNPs) or genes at 258 loci associated with colorectal cancer (CRC) risk. We studied the relationshi...
Artificial intelligence-powered discovery of small molecules inhibiting CTLA-4 in cancer [0.03%]
人工智能赋能发现抑制癌症中CTLA-4的小分子化合物
Navid Sobhani,Dana Rae Tardiel-Cyril,Dafei Chai et al.
Navid Sobhani et al.
Background/objectives: Checkpoint inhibitors, which generate durable responses in many cancer patients, have revolutionized cancer immunotherapy. However, their therapeutic efficacy is limited, and immune-related adverse ...
The author transitions his career in oncology to one in planetary health. The career pivot begins after he recognizes similarities between the pandemic and the climate crisis. The author determines that stepping away from his role as chair ...