Identification of cancer driver mutations in liquid-based cytology samples for the screening of endometrial diseases [0.03%]
用于筛查子宫内膜疾病的液基细胞学样本的癌症驱动突变识别
Motoki Matsuura,Kiyoko Takane,Kiyoshi Yamaguchi et al.
Motoki Matsuura et al.
Background: Endometrial cancer (EC) is one of the leading causes of cancer death among women and early detection is crucial for its successful treatment. We previously showed that cytological examination combined with gen...
Integrity matters in oncology: AORTIC takes a stand against research misconduct [0.03%]
肿瘤学讲求诚信：AORTIC 坚决反对科研不当行为
Khalid El Bairi,Dario Trapani,Laure-Anne Teuwen et al.
Khalid El Bairi et al.
Oncology is a rapidly evolving field globally, with a growing need to maintain research integrity. The African Organization for Research and Training in Cancer (AORTIC) has initiated a comprehensive training program to enhance research qual...
Chromosomal copy number based stratification of gastric cancer has added prognostic value to Lauren's histological classification [0.03%]
基于染色体拷贝数的胃癌亚型分类增进了Lauren组织学分型的预后价值
H D Biesma,T T D Soeratram,H F van Essen et al.
H D Biesma et al.
Background: The Cancer Genome Atlas (TCGA) recognizes four molecular subgroups of gastric cancer: Epstein-Barr virus (EBV) positive, microsatellite instable (MSI), genomically stable (GS), and chromosomal instable (CIN). ...
Phase II trial of pembrolizumab, ipilimumab, and aspirin in melanoma: clinical outcomes and translational predictors of response [0.03%]
派姆单抗、伊匹单抗和阿司匹林治疗黑色素瘤二期临床试验：临床结局及应答预测的转化指标
Zoe Quandt,Saya Jacob,Muhammad Zaki Hidayatullah Fadlullah et al.
Zoe Quandt et al.
Objective: Many patients with melanoma treated with immune checkpoint inhibitors (ICIs) do not derive response. Preclinical and retrospective studies identified that inhibition of the cyclooxygenase (COX) pathway may impr...
Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis [0.03%]
免疫组学和空间蛋白质组学揭示黑色素瘤与非黑色素瘤衍生脑转移灶中不同的神经-免疫架构
Alberto Mendoza-Valderrey,Ethan Dettmann,Douglas Hanes et al.
Alberto Mendoza-Valderrey et al.
Background: Brain metastases (BrMs) are a devastating complication of solid tumours. A better understanding of BrMs biology is needed to address their challenging clinical management. ...
Retrospective evaluation of plasma protein tumour markers for early lung cancer detection [0.03%]
回顾性评价血浆蛋白肿瘤标志物在早期肺癌检测中的作用
Michael Peter Alan Davies,Ruwanthi Kolamunnage-Dona,Suzannah Phillips et al.
Michael Peter Alan Davies et al.
Background: Blood-based biomarkers might help lung cancer diagnosis. A panel of serum tumour markers (TM) has been validated for hospital referrals due to clinical suspicion of lung cancer. We have compared plasma from a ...
Patterns of referrals to regional clinical genetics services for women potentially at above-population level risk of breast cancer [0.03%]
转诊至区域临床遗传学服务机构的乳腺癌患者潜在高危人群模式
Juliet A Usher-Smith,Georgia Tooth,Annabel Follows et al.
Juliet A Usher-Smith et al.
Background: The National Institute for Health and Care Excellence (NICE) recommends that women in England at above-population risk be offered additional breast screening and, depending on the level of risk, risk-reducing ...
Ropeginterferon alfa-2b shows anti-polycythaemia vera activity without causing clinically significant anaemia [0.03%]
Ropeginterferon α-2b治疗原发性红细胞增多症有效且不引起临床显著贫血
Keita Kirito,Albert Qin,Shanshan Suo et al.
Keita Kirito et al.
Anaemia could develop in polycythemia vera (PV) due to phlebotomy-caused iron-deficiency and cytotoxic effect of cytoreductive therapy. Ropeginterferon alfa-2b treatment was not associated with ≥grade 3 anaemia in two recent clinical studi...
Impact of underlying liver disease on unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors [0.03%]
基础肝病对不可切除性肝细胞癌免疫检查点抑制剂治疗的影响
Y Linda Wu,Sarah Cappuyns,Amanda Loh et al.
Y Linda Wu et al.
Background: Immune checkpoint inhibitors (ICIs) are standard therapy for unresectable HCC, but many patients do not respond. Non-viral HCC, particularly non-alcoholic steatohepatitis (NASH), have been implicated in ICI re...
An apparent quandary: adoption of polygenics and gene panels for personalised breast cancer risk stratification [0.03%]
一个明显的困境：采用多基因组学和基因组以实现个性化乳腺癌风险分类
Jerry S Lanchbury,Holly J Pederson
Jerry S Lanchbury
Over the past 30 years, genetic and epidemiological advances have revolutionised the prediction of breast cancer risk in women with significant family history. By screening these women for high- and intermediate-risk pathogenic variants and...