Loss of vimentin expression in preoperative biopsies independently predicts poor prognosis, lymph node metastasis and recurrence in endometrial cancer [0.03%]
术前活检中波形蛋白的丢失独立预示子宫内膜癌患者的不良预后、淋巴结转移和复发
Marta E Hjelmeland,Hilde E Lien,Hege F Berg et al.
Marta E Hjelmeland et al.
Background: Precise preoperative risk classification of endometrial cancer is crucial for treatment decisions. Existing clinical markers often fail to accurately predict lymph node metastasis and recurrence risk. Loss of ...
Weight, weight gain and behavioural risk factors in women attending a breast cancer family history, risk and prevention clinic: an observational study [0.03%]
女性就诊于乳腺癌遗传史、风险和预防专科门诊的体重、增重及行为危险因素观察性研究
Mary Pegington,John Belcher,Emma Barrett et al.
Mary Pegington et al.
Background: Weight and health behaviours impact on breast cancer risk. We describe trends in weight and health behaviours in women at entry to a specialist breast cancer family history clinic in Manchester, UK, and change...
Transdifferentiation of cervical squamous cell carcinoma with ERBB2 amplification to adenocarcinoma: whole genome sequence analysis and successful control by anti-HER2 therapy [0.03%]
宫颈鳞癌扩增型ERBB2向腺癌转分化：全基因组序列分析及抗HER2治疗成功控制案例报告
Hiroaki Ikushima,Kiyoshi Yamaguchi,Yoichi Furukawa et al.
Hiroaki Ikushima et al.
Cancer cells sometimes transdifferentiate into different histological type(s) and tumors with multiple histological types can share a common ancestor cell. However, diagnosis of the origin of multiple tumor lesions with different histologic...
Developing a risk prediction tool for lung cancer in Kent and Medway, England: cohort study using linked data [0.03%]
英格兰肯特和默伊地区肺癌风险预测工具的开发：基于多源数据关联的队列研究
David Howell,Ross Buttery,Padmanabhan Badrinath et al.
David Howell et al.
Background: Lung cancer has the poorest survival due to late diagnosis and there is no universal screening. Hence, early detection is crucial. Our objective was to develop a lung cancer risk prediction tool at a populatio...
Head and neck cancer mortality in the United States: Regional differences in hospice use and place of death [0.03%]
美国头颈部癌症死亡率：临终关怀使用情况及濒死地点的区域差异
Melissa C White,Julia E Canick,Tariq M Omer et al.
Melissa C White et al.
Background: With more than 15,000 annual deaths from head and neck cancer (HNC), an important aspect of end-of-life care for these patients is place of death. Recent evidence suggests an increasing preference for home/hos...
A practice changing paper: biallelic inactivation of BRCA2 in Fanconi anaemia [0.03%]
Fanconi 贫血与BRCA2的双等位基因失活：或将改变临床实践的研究成果
Diana Prepelita,Marc Tischkowitz
Diana Prepelita
Different efficacy of tyrosine kinase inhibitors by KIT and PGFRA mutations identified in circulating tumor DNA for the treatment of refractory gastrointestinal stromal tumors [0.03%]
KIT和PGFR基因突变胃肠道间质瘤患者循环肿瘤DNA检测指导TKI个体化治疗的疗效差异分析
Tadayoshi Hashimoto,Yoshiaki Nakamura,Yoshito Komatsu et al.
Tadayoshi Hashimoto et al.
Background: While advanced gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs), acquired resistance from specific mutations in KIT or PDGFRA frequently occurs. We aimed to ...
Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project [0.03%]
基因组分析与循环肿瘤DNA在转移性前列腺癌中的临床应用：SCRUM-Japan MONSTAR SCREEN项目
Masaki Shiota,Nobuaki Matsubara,Taigo Kato et al.
Masaki Shiota et al.
Background: Circulating tumor DNA (ctDNA) testing has emerged as a novel tool for cancer precision medicine. This study investigated the genomic profiling and clinical utility of ctDNA in metastatic prostate cancer. ...
The association between being breastfed in infancy and risks of cancer in adulthood-a UK Biobank study [0.03%]
婴儿接受母乳喂养与成年后癌症风险的关系——一项来自英国生物银行的研究
Dan Hameiri-Bowen,Dorthe C Pedersen,Britt W Jensen et al.
Dan Hameiri-Bowen et al.
Background: Being breastfed has established benefits for infant health, but its long-term effects on adult diseases, including cancer, remain underexplored. We examined associations between being breastfed in infancy and ...
Founder pathogenic variants in colorectal neoplasia susceptibility genes in Ashkenazi Jews undergoing colonoscopy [0.03%]
接受结肠镜检查的阿什肯纳兹犹太人中结直肠癌易感基因的致病突变创始人效应分析
Thibaut Matis,Celine Domecq,Nancy Hamel et al.
Thibaut Matis et al.
Background: Colorectal neoplasia is one of the most common tumors affecting Western populations. Methods: In this study we used a custo...