Phase 1b/2 study of the liposomal formulation of eribulin (E7389-LF) in combination with nivolumab: Results from the phase 2 esophageal cancer cohort [0.03%]
艾日布林脂质体制剂联合尼伏尤马布治疗食道癌二期临床试验结果
Takashi Oshima,Sachiko Yamamoto,Hisato Kawakami et al.
Takashi Oshima et al.
Background: Esophageal cancer is one of the most common types of cancer in Japan. Herein, we report the efficacy and safety of E7389-LF plus the immune checkpoint inhibitor, nivolumab, from the esophageal cancer cohort of...
C-reactive protein kinetics as a predictive marker for long-term outcome of immune checkpoint inhibitors in oesophagogastric cancer [0.03%]
免疫检查点抑制剂长期疗效预测标志物——胃食管癌患者循环中CRP水平动态变化及其临床意义
Yohei Nose,Takuro Saito,Yukinori Kurokawa et al.
Yohei Nose et al.
Background: The treatment efficacy of immune checkpoint inhibitors (ICIs) is limited, and biomarkers that identify responders are urgently needed. We investigated whether C-reactive protein (CRP) kinetics are associated w...
Therapeutic vulnerabilities and pan-cancer landscape of BRAF class III mutations in epithelial solid tumors [0.03%]
表皮固态肿瘤中BRAF三级突变的治疗弱点和癌症全景图谱
Eylül Özgü,Benjamin G Kaplan,Smruthy Sivakumar et al.
Eylül Özgü et al.
Background: Kinase-impaired class III BRAF mutations have recently received attention as a possible prognostic factor and therapeutic target. Class III BRAF variants differ from class I and class II mutations in terms of ...
Incidental finding of leukaemia in circulating tumour DNA- the importance of a molecular tumour board [0.03%]
循环肿瘤DNA中白血病的偶然发现——分子肿瘤委员会的重要性
Justin Mencel,Neha Rayarel,Paula Proszek et al.
Justin Mencel et al.
As the use of liquid biopsies are increasing across multiple indications in cancer medicine, the detection of incidental findings on circulating tumour DNA is of increasing importance. We report the finding of leukaemia detected in a patien...
Malignant peritoneal mesothelioma interactome with 417 novel protein-protein interactions [0.03%]
恶性腹膜间皮瘤蛋白质互作网络及417种新蛋白-蛋白相互作用关系
Kalyani B Karunakaran,Madhavi K Ganapathiraju
Kalyani B Karunakaran
Background: Malignant peritoneal mesothelioma (MPeM) is an aggressive cancer affecting the abdominal peritoneal lining and intra-abdominal organs, with a median survival of ~2.5 years. ...
Long-term survival following anti-PD-(L)1 monotherapy in advanced urothelial cancer and an assessment of potential prognostic clinical factors: a multicentre observational study [0.03%]
抗PD-(L)1单药长期治疗晚期尿路上皮癌的生存情况及潜在预后因素的评估：一项多中心观察性研究
Chantal F Stockem,Sarah M H Einerhand,Isabel Miras Rodríguez et al.
Chantal F Stockem et al.
Background: Anti-PD-(L)1 agent are approved as first- and second-line treatment options in advanced urothelial cancer (UC), but information about long-term survival is scarce. There is a need for prognostic factors, as th...
Fulvestrant plus vandetanib versus placebo for the treatment of patients with metastatic breast cancer resistant to aromatase inhibitor therapy (FURVA): a multicentre, Phase 2, randomised controlled trial [0.03%]
氟维司群联合凡德他尼与安慰剂治疗芳香化酶抑制剂难治性转移性乳腺癌患者的疗效研究（FURVA）：一项多中心Ⅱ期随机对照试验
Mark Beresford,Angela Casbard,Zoe Hudson et al.
Mark Beresford et al.
Background: FURVA, a randomised, double-blind Phase II trial, investigated whether the addition of vandetanib to fulvestrant improved progression-free survival (PFS) in patients with an aromatase inhibitor(AI)-resistant a...
Implications of HPV infectivity in early diagnosis and treatment of advanced/recurrent malignancies [0.03%]
人乳头瘤病毒传染性在早期诊断和治疗晚期/复发恶性肿瘤中的影响
Takuma Hayashi,Ikuo Konishi
Takuma Hayashi
Human papillomavirus (HPV) genotype infection causes cervical cancer, pharyngeal cancer, etc. The amount of circulating HPV DNA in the blood helps in detecting advanced/recurrent cancer earlier than with tumour marker elevation. Cancer immu...
Seamus O&#x;Reilly,Catherine S Weadick,Rachel J Keogh
Seamus O&#x;Reilly
Protein prognostic biomarkers in stage II colorectal cancer: implications for post-operative management [0.03%]
II期结直肠癌的蛋白质预后生物标志物：对术后管理的意义
Aziz A A Alnakli,Abidali Mohamedali,Benjamin Heng et al.
Aziz A A Alnakli et al.
Colorectal cancer (CRC) poses a significant threat to many human lives worldwide and survival following resection is predominantly stage dependent. For early-stage cancer, patients are not routinely advised to undergo additional post-operat...