HER2 amplification and HER2 low expression in endometrial carcinoma: prevalence across molecular, histological and clinicopathological risk groups [0.03%]
子宫内膜癌中HER2扩增与低表达的分布特征及其在分子分型、组织学和临床病理风险组中的差异性分析
Karoliina Aro,Mikko Loukovaara,Ralf Bützow et al.
Karoliina Aro et al.
Background: Emerging HER2-targeted therapies provide new treatment options for patients with HER2-expressing tumors. This study investigates the prevalence of HER2 amplification and HER2 low expression across a well-chara...
The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer [0.03%]
肿瘤坏死、全身性炎症、机体成分与结直肠癌患者的生存期之间的关系
Ross D Dolan,Kathryn Pennel,Joshua Thompson et al.
Ross D Dolan et al.
Background: In cancer cachexia the relationship between the tumour, its environment and the systemic inflammatory response is not clear. This study aims to examine this relationship in greater detail. ...
A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration [0.03%]
TLR4激动剂通过促进CD8+CTL浸润抑制成骨肉瘤肺转移及肿瘤生长
Ryunosuke Oyama,Akira Nabeshima,Makoto Endo et al.
Ryunosuke Oyama et al.
Background: Osteosarcoma is the most common malignant bone tumour with limited treatment options and poor outcomes in advanced metastatic cases. Current immunotherapies show limited efficacy, highlighting the need for nov...
Cian Campion,Linda Robertson,Ian Stansfield et al.
Cian Campion et al.
Single-use plastics (SUPs) are used widely in cancer research laboratories. They are cheap, durable, and lightweight, and until now have been considered disposable items. This, however, contributes significantly to unsustainable waste produ...
Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy [0.03%]
靶向抗体-药物偶联物在黑色素瘤中激活别构构象的内皮素受体B：机制和治疗效果
Amaury Herbet,Marie Hautière,Frédéric Jean-Alphonse et al.
Amaury Herbet et al.
Background: Endothelin 1 receptors are one of the drivers of tumor progression in many cancers. Inhibition of their signaling pathways with antagonist drugs has been the subject of numerous clinical trials, but the result...
Serum laminin γ2 monomer as a novel diagnostic and prognostic marker for pancreatic ductal adenocarcinoma [0.03%]
血清层粘连蛋白γ2单体作为胰腺导管腺癌的新型诊断和预后标志物
Takeshi Terashima,Kouki Nio,Naohiko Koshikawa et al.
Takeshi Terashima et al.
Background: The identification of effective diagnostic and prognostic biomarkers is critical to improving the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC). We explored the potential of serum levels of...
A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors [0.03%]
一项关于CDK4/6抑制剂里博西利联合吉西他滨治疗晚期实体瘤患者I期临床研究
Aurora Norman,Mahesh Seetharam,Jacob Allred et al.
Aurora Norman et al.
Background: Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine was synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose l...
Long term follow-up of women treated for screen detected atypical ductal hyperplasia or lobular neoplasia in a large UK screening centre [0.03%]
英国一大型筛查中心导管原位异常增生或小叶原位病变的长期随访研究
Nicole L Brown,Susan Pritchard,Elaine F Harkness et al.
Nicole L Brown et al.
Background: Atypical ductal hyperplasia (ADH) and lobular neoplasia (LN) increase subsequent breast cancer (BC) risk. However, optimal surveillance and risk reduction regimes remain uncertain. We report management and out...
Increased potentiation of 5-fluorouracil induced thymidylate synthase inhibition by 5,10-methylenetetrahydrofolate (arfolitixorin) compared to leucovorin in patients with colorectal liver metastases; The Modelle-001 Trial [0.03%]
与左亚叶酸相比，亚甲基四氢叶酸（阿福替尼）在增加氟尿嘧啶诱导的胸苷酸合成酶抑制作用方面的效果更佳：META-001试验结果
Helena Taflin,Elisabeth Odin,Göran Carlsson et al.
Helena Taflin et al.
Background: 5-Fluorouracil (5-FU) is a cornerstone in treatment of colorectal cancer (CRC) and is usually combined with leucovorin (LV) to enhance the antitumour effect by increase thymidylate synthase (TS) inhibition, th...
Single-cell RNA-seq analysis of cancer-endothelial cell interactions in primary tumor and peritoneal metastasis from a single patient with colorectal cancer [0.03%]
结直肠癌患者原发灶及腹膜转移灶肿瘤内皮细胞互作的单细胞RNA测序分析
Yuri Sakimoto,Kohei Kumegawa,Shimpei Matsui et al.
Yuri Sakimoto et al.
Background: Peritoneal metastasis, a major complication of colorectal cancer (CRC), often leads to poor quality of life and unfavorable outcomes. Despite numerous studies characterizing its biological features in CRC, int...