Cancer risk according to lifestyle risk score trajectories: a population-based cohort study [0.03%]
基于人群的队列研究中生活方式风险评分的变化与癌症发病风险的关系
Thi Minh Thu Khong,Thi Tra Bui,Hee-Yeon Kang et al.
Thi Minh Thu Khong et al.
Background: While individual lifestyle behaviors have been associated with cancer risk, combined impact of these factors remains understudied. This research explores relationships between lifestyle risk score trajectories...
Monitoring circulating tumor DNA by recurrent hotspot mutations in bladder cancer [0.03%]
通过反复出现的热点突变监测膀胱癌循环肿瘤DNA
Shigehiro Tsukahara,Masaki Shiota,Takashi Matsumoto et al.
Shigehiro Tsukahara et al.
Background: Liquid biopsy can evaluate minimally residual disease. Hotspot mutations are also common in non-coding regions among the MIBC patients. We evaluated the status of MIBC with hotspot mutations with cfDNA. ...
Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis [0.03%]
胶质母细胞瘤的代谢重组：一例复发至头皮转移的罕见病例
Amir Barzegar Behrooz,Hamid Latifi-Navid,Narges Zolfaghari et al.
Amir Barzegar Behrooz et al.
Background: Glioblastoma (GB), an aggressive brain malignancy with a poor prognosis of 1.5-2 years, rarely exhibits extracranial metastasis (ECM). However, metabolic reprogramming has emerged as a key driver of GB progres...
Exploring the effect of differing centre hydration and anti-emetic policies on acute gastrointestinal and renal toxicities in the De-ESCALaTE trial [0.03%]
不同中心的水化和止吐政策对De-ESCALaTE试验中急性胃肠毒性及肾毒性的不同影响分析
Anthony Kong,Matthew Hazell,Gulnaz Iqbal et al.
Anthony Kong et al.
Background: The De-ESCALaTE trial confirmed the superiority of cisplatin over cetuximab in combination with radiotherapy for the treatment of low risk HPV+ oropharyngeal cancer (HPV + OPC). However, there were concerns ab...
Younger-onset type 2 diabetes associated with increased long-term cancer risk in Chinese adults: A 30-year follow-up of the Da Qing Diabetes Study [0.03%]
大庆糖尿病研究的30年随访：年轻发病的2型糖尿病与中国人长期癌症风险增加有关
Siyao He,Xin Qian,Jinping Wang et al.
Siyao He et al.
Background: We investigated the association between younger-onset type 2 diabetes, duration of diabetes, and cancer risk based on data from the Da Qing Diabetes Prevention Outcome Study (DQDPOS). ...
Mia Dunn,Lewis Dymock,Clare Hoskins
Mia Dunn
Pancreatic cancer comes with one of the poorest prognoses of all cancers and as such it is crucial that new therapies are developed to improve on the current statistics. Currently, chemotherapy is the cornerstone of pancreatic cancer treatm...
Mangesh A Thorat
Mangesh A Thorat
Immune checkpoint inhibitor therapy is associated with a decreased risk of developing melanoma brain metastases [0.03%]
免疫检查点抑制剂治疗与降低黑色素瘤脑转移风险相关
Anna Fager,Matilda Samuelsson,Roger Olofsson Bagge et al.
Anna Fager et al.
Background: Despite recent advancements in metastatic melanoma treatment, the emergence of melanoma brain metastases (MBM) continues to pose a challenge. This study aimed to explore factors associated with MBM development...
Increasing use of artificial intelligence in genomic medicine for cancer care- the promise and potential pitfalls [0.03%]
基因组医学在癌症治疗中越来越多地使用人工智能——希望与潜在的陷阱
Olivia O&#x;Connor,Terri P McVeigh
Olivia O&#x;Connor
The field of genomic medicine produces large datasets, which need to be rapidly analysed to produce clinically actionable insights in cancer care. Artificial intelligence thrives on data, processing and learning from datasets with a degree ...
Germline copy number variants in RUNX1: An updated case report and a decade-old red herring [0.03%]
RUNX1的种系拷贝数变异：一个更新的病例报告和十年之久的假线索
Natalie T Deuitch,Amra Kajdic,Erica Bresciani et al.
Natalie T Deuitch et al.
Pathogenic/likely pathogenic (P/LP) germline variants in RUNX1 cause familial platelet disorder with associated myeloid malignancies (FPDMM), also known as RUNX1-Familial Platelet Disorder (RUNX1-FPD, or FPD), a condition characterized by q...