Primary tumour location, molecular alterations, treatments, and outcome in a population-based metastatic colorectal cancer cohort [0.03%]
取自某地的转移性结直肠癌队列的原发灶位置、分子改变、治疗及预后状况
Emerik Osterlund,Klara Hammarström,Luís Nunes et al.
Emerik Osterlund et al.
Background: Metastatic colorectal cancer (mCRC) patients in trials are selected. The aim was to study mCRC features population-based. Methods: ...
Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes [0.03%]
单细胞分析揭示肿瘤大小是乳腺原发性肿瘤和相应淋巴结中免疫细胞谱系改变的关键驱动因素
Marit Otterlei Fjørtoft,Øystein Garred,Ole Christian Lingjærde et al.
Marit Otterlei Fjørtoft et al.
Background: At diagnosis, 30-40% of women with breast cancer have metastases in sentinel (SN) or axillary lymph nodes (ALN). Nodal status is a strong prognostic factor and guides treatment decisions. Immune checkpoint inh...
Next-generation sequencing outperforms Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) in endometrial cancer molecular classification [0.03%]
新一代测序在子宫内膜癌分子分类中优于前瞻性分子风险分类器(ProMisE)
Takuma Yoshimura,Kohei Nakamura,Tatsuyuki Chiyoda et al.
Takuma Yoshimura et al.
Background: We aimed to compare the values of next-generation sequencing (NGS) and Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) in redefining the molecular classification of endometrial cancer (EC)...
Stereotactic ablative radiotherapy for patients with hepatocellular carcinoma: analysis of post-treatment radiology and explant histology [0.03%]
肝细胞癌患者的立体定向消融放射治疗：术后放射学和切除组织病理分析
Nekisa Zakeri,Ramanivas Sundareyan,Owen Cain et al.
Nekisa Zakeri et al.
Background: Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment modality for hepatocellular carcinoma (HCC). Evaluation of tumour responses following SABR are currently based on conventional radiologi...
Deep learning-based interpretable prediction of recurrence of diffuse large B-cell lymphoma [0.03%]
基于深度学习的弥漫性大B细胞淋巴瘤复发可解释预测方法
Hussein Naji,Paul Hahn,Juan I Pisula et al.
Hussein Naji et al.
Background: The heterogeneous and aggressive nature of diffuse large B-cell lymphoma (DLBCL) presents significant treatment challenges as up to 50% of patients experience recurrence of disease after chemotherapy. Upfront ...
Assessing the risk of second primary lung cancer in women after previous breast cancer [0.03%]
既往患乳腺癌女性继发肺癌的风险评估
Yuanhui Huang,Jenny J Lin,Juan P Wisnivesky et al.
Yuanhui Huang et al.
Background: Breast cancer (BC) survivors may be at increased risk of developing second cancers compared to those without BC diagnosis due to shared risk factors and potential carcinogenic effects of cancer therapy. Lung c...
Association of HER2 amplification or overexpression with overall survival in advanced upper gastrointestinal adenocarcinomas [0.03%]
HER2扩增或过表达与晚期消化道腺癌总生存期的关系研究
Minggui Pan,Arun Dang,Tina Huang et al.
Minggui Pan et al.
Background: Advanced esophageal (EAC), gastroesophageal junction (GEJAC) and gastric (GAC) adenocarcinomas with HER2 amplification or overexpression (HER2+) are routinely treated with trastuzumab. However, it remains uncl...
Anjum Memon,Yalda Salari,Manraj Bawa et al.
Anjum Memon et al.
Background: The incidence of kidney cancer, which is 34% attributable to obesity and smoking, has been steadily increasing over the past few decades in many countries in Europe, North America and Oceania. In recent years,...
Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients [0.03%]
基于基因组学和集成临床数据的机器学习评分模型在判断可能患林奇综合征患者中的应用
Ramadhani Chambuso,Takudzwa Nyasha Musarurwa,Alessandro Pietro Aldera et al.
Ramadhani Chambuso et al.
Background: Lynch syndrome (LS) screening methods include multistep molecular somatic tumor testing to distinguish likely-LS patients from sporadic cases, which can be costly and complex. Also, direct germline testing for...
Case report of three patients with end-stage recurrent glioblastoma treated with meldonium [0.03%]
三种终末期复发胶质母细胞瘤患者使用麦角硫宁治疗的病例报告
Sandra Bien-Möller,Martin E Weidemeier,Josefine Radke et al.
Sandra Bien-Möller et al.
Background: Glioblastoma is the most aggressive primary brain tumor in adults. The prognosis is still very poor with a median survival time less than a year. A growing body of data supports the role for fatty acid oxidati...