Fabian Frost,Markus M Lerch
Fabian Frost
Josef Heusinger,Paul Czech,Heidi Hengstler et al.
Josef Heusinger et al.
Paraneoplastic leukocytosis in solid tumors is associated with poor prognosis. While mild leukocytosis is common, paraneoplastic hyperleukocytosis is extremely rare. The case of a 73-year-old male diagnosed with an adenocarcinoma of the lun...
Raphael Teipel,Malte von Bonin,Friedrich Stölzel et al.
Raphael Teipel et al.
The detection of clonal hematopoiesis (CH) in patients with hematologic neoplasms who are undergoing a cellular therapy is common. The most frequently used cellular therapy procedures include autologous and allogeneic hematopoietic stem cel...
Christopher Maximilian Arends,Frederik Damm
Christopher Maximilian Arends
Background: Clonal hematopoiesis (CH) is a premalignant state of the hematopoietic system that frequently occurs in old age and is associated with an elevated cardiovascular risk and higher overall mortality. ...
[Management of chronic heart failure: state of the art according to the 2021 guideline] [0.03%]
慢性心力衰竭的管理：2021指南解读
Kristian Hellenkamp,Miroslava Valentova,Stephan von Haehling
Kristian Hellenkamp
Treatment of heart failure with reduced ejection fraction (HFrEF) requires four drug classes that should be initiated simultaneously and up-titrated rapidly. All four have received class I recommendations. Sacubitril/valsartan can be consid...
Katharina S Götze,Claudia Lengerke
Katharina S Götze
Background: Clonal hematopoiesis of indeterminate potential (CHIP) is a fairly newly described phenomenon characterized by myeloid cancer-associated somatic mutations detectable in the peripheral blood of individuals with...
[Diagnostics in unclear cytopenia-How and when do we screen for clonal hematopoiesis?] [0.03%]
[不确定血细胞减少症的诊断-我们如何以及何时筛查克隆性血液异常?]
Claudia Haferlach,Michael Heuser
Claudia Haferlach
Background: Many studies have analyzed the clinical significance of clonal hematopoiesis. The collected data lead to the conclusion that in defined clinical constellations a targeted diagnostic search for clonal hematopoi...
Münevver Demir,Frank Tacke
Münevver Demir
Research over the last two decades has highlighted the major role played by the gut microbiota in health and disease, including chronic liver diseases. The liver and intestine communicate via the portal vein, biliary system, and mediators i...
Fabian Frost
Fabian Frost
The human body is colonized by a multitude of different microbes that are collectively referred to as the human microbiome. Gut microbes account for the largest proportion of these. They constitute a barrier against foreign pathogens, carry...
Andreas Stallmach,Arndt Steube,Johannes Stallhofer et al.
Andreas Stallmach et al.
Fecal microbiome transfer (FMT) involving the transfer of the microbiome of healthy stool donors to patients with various diseases has been performed in Germany in clinical studies and individual treatment attempts. There is no doubt that F...