Katharina S Götze,Claudia Lengerke
Katharina S Götze
Background: Clonal hematopoiesis of indeterminate potential (CHIP) is a fairly newly described phenomenon characterized by myeloid cancer-associated somatic mutations detectable in the peripheral blood of individuals with...
[Diagnostics in unclear cytopenia-How and when do we screen for clonal hematopoiesis?] [0.03%]
[不确定血细胞减少症的诊断-我们如何以及何时筛查克隆性血液异常?]
Claudia Haferlach,Michael Heuser
Claudia Haferlach
Background: Many studies have analyzed the clinical significance of clonal hematopoiesis. The collected data lead to the conclusion that in defined clinical constellations a targeted diagnostic search for clonal hematopoi...
Münevver Demir,Frank Tacke
Münevver Demir
Research over the last two decades has highlighted the major role played by the gut microbiota in health and disease, including chronic liver diseases. The liver and intestine communicate via the portal vein, biliary system, and mediators i...
Fabian Frost
Fabian Frost
The human body is colonized by a multitude of different microbes that are collectively referred to as the human microbiome. Gut microbes account for the largest proportion of these. They constitute a barrier against foreign pathogens, carry...
Andreas Stallmach,Arndt Steube,Johannes Stallhofer et al.
Andreas Stallmach et al.
Fecal microbiome transfer (FMT) involving the transfer of the microbiome of healthy stool donors to patients with various diseases has been performed in Germany in clinical studies and individual treatment attempts. There is no doubt that F...
[Role of the gut microbiome in the development and transfer of antibiotic resistances] [0.03%]
[肠道微生物组在抗生素抗性发展和传播中的作用]
Tobias M Appel,Maria J Vehreschild
Tobias M Appel
Antimicrobial resistance (AR) is a natural phenomenon resulting from the exposure of bacteria to antibacterial substances. The intestinal microbiome plays a central role in the development and transmission of AR. In its physiological state,...
[Role of the gut microbiome in the pathogenesis and treatment of inflammatory bowel diseases] [0.03%]
[肠道菌群在炎症性肠病发病机制和治疗中的作用]
Jan Kempski,Samuel Huber
Jan Kempski
Inflammatory bowel diseases (IBD) are systemic diseases that mainly manifest in the gastrointestinal tract. Due to chronically impaired intestinal homeostasis, they often require permanent and in some cases systemic therapy. The exact cause...
[Rhabdomyolysis due to drug-drug interaction of atorvastatin and cobicistat] [0.03%]
阿托伐他汀与柯博西特相互作用导致横纹肌溶解症一例报告
E Intert,M Krause,F Hennersdorf et al.
E Intert et al.
A 53-year-old man presented with rhabdomyolysis and acute kidney injury. The symptoms were presumably caused by a drug-drug interaction between an antiretroviral drug combination and atorvastatin. As a booster, cobicistat can also increase ...
Andreas Burchert
Andreas Burchert
Clonal hematopoiesis of indeterminate potential (CHIP) refers to hematopoiesis from stem cells with mutations in leukemia-associated driver genes. These confer increased stress tolerance and expansive potential to stem cell clones. Patients...
Alexander Schultze,Ulrich Mayer-Runge
Alexander Schultze
The interdisciplinary central emergency department is increasingly establishing itself as the new gold standard of inpatient emergency care. Not all emergency patients whose complaints need to be assessed with the resources of an emergency ...