Proteogenomic signature of Alzheimer's disease and related dementia risk in individuals with major depressive disorder [0.03%]
抑郁症相关人士的阿尔茨海默病和痴呆风险蛋白基因组标志物研究
Breno Satler Diniz,Zhiduo Chen,David C Steffens et al.
Breno Satler Diniz et al.
The mechanisms linking a history of major depressive disorder (MDD) to an increased risk of Alzheimer's disease and related dementia (ADRD) are not fully understood. Using the UK Biobank, we evaluated the biological mechanisms linking both ...
Cognitive behavioral therapy for antiretroviral therapy adherence and treatment outcomes among people living with HIV: a systematic review and meta-analysis [0.03%]
认知行为疗法对艾滋病病毒携带者接受抗逆转录病毒治疗的依从性和治疗效果的影响：系统综述和.meta.分析
David R A Coelho,Belinda J Njiro,Mashavu H Yussuf et al.
David R A Coelho et al.
Cognitive behavioral therapy has emerged as a promising intervention to enhance antiretroviral therapy adherence among people living with HIV. Here we conducted a systematic review and meta-analysis to evaluate the efficacy of cognitive beh...
The ethical imperative of self-directed tools in crisis helplines to prevent suicide at scale [0.03%]
危机援助热线中预防大规模自杀的自主工具伦理要求
Jonah Meyerhoff,Daniel D L Coppersmith,Kathryn R Fox
Jonah Meyerhoff
Using the United States' National Suicide and Crisis Lifeline as a case example, we discuss the tacit requirement that users of helplines disclose suicide-related thoughts and behaviors as a central barrier to suicide prevention interventio...
Predicting suicide attempts among US Army soldiers using information available at the time of periodic health assessments [0.03%]
基于定期健康检查信息预测美国陆军士兵的自杀行为
James A Naifeh,Emily R Edwards,Kate H Bentley et al.
James A Naifeh et al.
The value of population screening for suicide risk remains unclear. The U.S. Army's annual medical examination, the Periodic Health Assessment (PHA), screens for suicidality and other mental and physical health problems. This 2014-2019 coho...
Psychological stress, cardiovascular disease and somatic pain in asylum seekers: a retrospective cross-sectional study [0.03%]
难民的心理压力、心血管疾病和躯体疼痛：一项回顾性横断面研究
Jacob Michael Lurie,Harlan Linver Pietz,Claudia Hatef et al.
Jacob Michael Lurie et al.
The refugee experience is a known risk factor for psychological stress, cardiovascular disease (CVD) and somatic pain. However, the prevalence and comorbidity of these health outcomes in asylum seekers is not elucidated. Here we performed a...
Neuroimaging insights into brain mechanisms of early-onset restrictive eating disorders [0.03%]
神经影像学揭示早期发病限制型进食障碍的大脑机制
Clara A Moreau,Anael Ayrolles,Christopher R K Ching et al.
Clara A Moreau et al.
Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant/restrictive food intake disorders (ARFID). However, the impact of rEO-ED on brain m...
A record-linkage study of post-stroke primary care psychological therapy effectiveness in England [0.03%]
英国全科医疗心理治疗卒中后疗效的记录链接研究
Jae Won Suh,Vaughan Bell,Joshua E J Buckman et al.
Jae Won Suh et al.
At least one-third of stroke survivors are affected by depression or anxiety, but no large-scale studies of real-world clinical practice have assessed whether psychological therapies are beneficial for these patients. Here we show that psyc...
Chronic loneliness and isolation phenotypes, incident functional impairment and mortality in England between 2004 and 2018 [0.03%]
2004年至2018年期间英国慢性孤独与孤立表型、新发功能障碍和死亡率的关系
Qian Gao,Andrew Steptoe,Daisy Fancourt
Qian Gao
Social deficits are potential risk factors for premature mortality. Most research has focused on social deficits measured at single points in time. It remains unclear if the chronicity of loneliness affects its impact on adverse health outc...
The Global Flourishing Study: Study Profile and Initial Results on Flourishing [0.03%]
全球繁荣研究：研究概况及初步结果分析
Tyler J VanderWeele,Byron R Johnson,Piotr T Bialowolski et al.
Tyler J VanderWeele et al.
The Global Flourishing Study is a longitudinal panel study of over 200,000 participants in 22 geographically and culturally diverse countries, spanning all six populated continents, with nationally representative sampling and intended annua...
Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management [0.03%]
与运动皮层相关的感觉迟钝在慢性疼痛管理中的新兴作用及其神经环路基础
Yang Bai,Kevin Pacheco-Barrios,Niels Pacheco-Barrios et al.
Yang Bai et al.
Aside from movement initiation and control, the primary motor cortex (M1) has been implicated in pain modulation mechanisms. A large body of clinical data has demonstrated that stimulation and behavioral activation of M1 result in clinicall...