Defining the r factor for post-trauma resilience and its neural predictors [0.03%]
创伤后弹性的r因素及其神经预测因素的界定
Sanne J H van Rooij,Justin L Santos,Cecilia A Hinojosa et al.
Sanne J H van Rooij et al.
Although resilience is a dynamic process of recovery after trauma, in most studies it is conceptualized as the absence of specific psychopathology following trauma. Here, using the emergency department AURORA study (n = 1,835 with 63% women...
Longitudinal association between neighborhood-level social capital and incidence of major psychiatric disorders in a cohort of 1.4 million people in Sweden [0.03%]
瑞典一项涉及140万人队列研究中邻里社会资本与主要精神病发病率纵向关联性分析
Angela Song-Chase,Jennifer Dykxhoorn,Anna-Clara Hollander et al.
Angela Song-Chase et al.
Social capital-the trust and cohesion within communities-has been linked to mental health, yet longitudinal evidence remains scarce. Here we show that neighborhood-level personal trust predicts the incidence of severe mental illness in a la...
Emotion processing and electrodermal activity in young people who self-harm [0.03%]
自我伤害青年的情绪处理和皮电活动研究
Karen Wetherall,Seonaid Cleare,Nadia Belkadi et al.
Karen Wetherall et al.
The biological underpinnings of self-harm in young people are unclear. Self-harm often serves to regulate emotions, and electrodermal activity (EDA) is a well-established biomarker of emotional arousal, which is physiologically related to e...
The BMIgap tool to quantify transdiagnostic brain signatures of current and future weight [0.03%]
BMIgap工具：量化当前和未来体重的跨诊断脑特征
Adyasha Khuntia,David Popovic,Elif Sarisik et al.
Adyasha Khuntia et al.
Understanding the neurobiological underpinnings of weight gain could reduce excess mortality and improve long-term trajectories of psychiatric disorders. Using brain scans from healthy individuals (n = 1,504), we trained a model to predict ...
The effect of sertraline on networks of mood and anxiety symptoms: secondary analysis of the PANDA randomized controlled trial [0.03%]
舍曲林对情绪和焦虑症状网络的影响：PANDA随机对照试验的二次分析
Giulia G Piazza,Andrea G Allegrini,Larisa Duffy et al.
Giulia G Piazza et al.
Depression consists of heterogeneous symptoms that can occur in hundreds of possible combinations. However, intervention studies commonly operationalize depression as a homogeneous condition. Here we adopt a symptom-level approach to test t...
A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression [0.03%]
分层的精确医学试验针对α2A-肾上腺素能受体激动剂治疗抑郁的认知表型
Laura M Hack,Jenna Jubeir,Rachel Hilton et al.
Laura M Hack et al.
Cognitive impairments are a major contributor to psychosocial dysfunction in major depressive disorder, yet mechanistically selective treatments targeting these impairments are lacking. Here, in line with a precision medicine approach, we e...
Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma [0.03%]
创伤后早期脑内网络状态与 PTSD 症状加重有关
Mohammad Se Sendi,Zening Fu,Nathaniel G Harnett et al.
Mohammad Se Sendi et al.
Post-traumatic stress (PTS) encompasses a range of psychological responses following trauma, which may lead to more severe outcomes such as post-traumatic stress disorder (PTSD). Identifying early neuroimaging biomarkers that link brain fun...
Intracranial electrophysiological biomarkers of compulsivity in obsessive-compulsive disorder [0.03%]
强迫症中与强迫行为相关的颅内电生理生物标志物
Tara Arbab,Melisse N Bais,Martijn Figee et al.
Tara Arbab et al.
There is an emerging need for objective neural biomarkers of obsessive-compulsive disorder (OCD) to improve the efficacy of neuromodulatory interventions, most notably deep-brain stimulation (DBS), and develop closed-loop stimulation paradi...
A systematic review of the effects of chronic, slow-onset climate change on mental health [0.03%]
慢性气候变化对精神健康的影响——系统综述研究
Kate Burrows,Christy A Denckla,Jill Hahn et al.
Kate Burrows et al.
The mental health effects of weather-related disasters are well characterized, yet less is known about the effect of chronic, slow-onset climate change. We systematically reviewed qualitative, quantitative and mixed-methods studies (57 were...
A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison [0.03%]
基于甲基化的大样本抑郁症关联分析及跨祖源人群验证研究
Xueyi Shen,Miruna Barbu,Doretta Caramaschi et al.
Xueyi Shen et al.
Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studie...