Predicting Firearm Suicide among US Army Veterans Transitioning from Active Service [0.03%]
预测美国现役军人退伍后的 firearm 自杀率
Claire Houtsma,Chris J Kennedy,Howard Liu et al.
Claire Houtsma et al.
United States (US) Veterans are significantly more likely to die by suicide than civilians. Machine learning (ML) models have been developed to target high-risk transitioning service members for suicide prevention interventions to reduce Ve...
Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia [0.03%]
与衰老和痴呆相关的生物物理机制的多样性敏感型大脑时钟
Carlos Coronel-Oliveros,Sebastián Moguilner,Hernan Hernandez et al.
Carlos Coronel-Oliveros et al.
Brain clocks track the deviations between predicted brain age and chronological age (brain age gaps, BAGs). These BAGs can be used to measure accelerated aging, monitoring deviations from the healthy brain trajectories associated with brain...
A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations [0.03%]
基于欧洲参考人群遗传背景的青少年人群跨障碍遗传易感性的泛表型关联研究
Sarah E Paul,Sarah M C Colbert,Aaron J Gorelik et al.
Sarah E Paul et al.
Etiologic insights into psychopathology may be gained by using hypothesis-free methods to identify associations between genetic risk for broad psychopathology and phenotypes measured during adolescence, including both markers of child psych...
Attention-mediated genetic influences on psychotic symptomatology in adolescence [0.03%]
注意缺陷介导的青少年精神病症状的遗传影响
Sarah E Chang,Dylan E Hughes,Jinhan Zhu et al.
Sarah E Chang et al.
Attention problems are among the earliest precursors of schizophrenia. In this longitudinal cohort study, we examine relationships between cognitive and neuropsychiatric polygenic scores (PGSs), psychosis-spectrum symptoms and attention-rel...
An umbrella review of psychological capacity and mental health trajectories across the life course [0.03%]
生命周期中心理能力和精神健康轨迹的伞状回顾性研究
Darío Moreno-Agostino,Nusrat Khan,Vanessa De Rubeis et al.
Darío Moreno-Agostino et al.
Understanding population trajectories of psychological capacities can guide interventions to protect and enhance them across the life course. We conducted an umbrella review of systematic reviews examining the trajectories of a wide range o...
The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort [0.03%]
社会不利经历、外周血微小核糖核酸表达与应激关系的前瞻性队列研究
Chengqi Wang,Monica Uddin,Agaz Wani et al.
Chengqi Wang et al.
Epigenetic processes serve as both mediators of and responders to social and environmental challenges, influencing biological outcomes. Therefore, pinpointing epigenetic factors associated with social adversity and traumatic stress enables ...
Polygenic score for C-reactive protein is linked to faster cortical thinning and psychopathology risk in adolescents [0.03%]
多基因评分与青少年C反应蛋白水平升高相关的皮层变薄加速和心理健康风险增加
Haixia Zheng,Jonathan Savitz,Ebrahim Haroon et al.
Haixia Zheng et al.
Adolescence is a sensitive period of brain development marked by rapid cortical thinning and increased risk for psychiatric disorders, yet the biological drivers of atypical trajectories remain unclear. Here, using longitudinal data from th...
A systematic review of income and education reporting in psychedelic clinical trials [0.03%]
关于迷幻药临床试验中收入和教育报告的系统性回顾
Daniel H Grossman,Kevin M Madden,Nicky J Mehtani et al.
Daniel H Grossman et al.
Socioeconomic status (SES) significantly influences mental health outcomes and treatment access, yet its reporting in psychedelic-assisted therapy trials remains underexplored. Here we systematically reviewed 98 articles (49 primary trials ...
Non-Invasively Targeting, Probing, and Modulating a Deep Brain Circuit for Depression Alleviation [0.03%]
非侵入性地针对、探测和调制深层脑回路以缓解抑郁症状
Desmond J Oathes,Romain J-P Duprat,Justin Reber et al.
Desmond J Oathes et al.
Effective repetitive transcranial magnetic stimulation (rTMS) treatment for depression has often focused on modulating the subgenual anterior cingulate cortex (sgACC), yet no studies have related TMS-evoked responses in the sgACC to clinica...
Early detection of dementia with default-mode network effective connectivity [0.03%]
利用默认模式网络有效连接的早期痴呆检测
Sam Ereira,Sheena Waters,Adeel Razi et al.
Sam Ereira et al.
Altered functional connectivity precedes structural brain changes and symptoms in dementia. Alzheimer's disease is the largest contributor to dementia at the population level, and disrupts functional connectivity in the brain's default-mode...