The overlapping genetic architecture of psychiatric disorders and cortical brain structure [0.03%]
精神病障碍与皮层脑结构的重叠遗传架构
Zhiqiang Sha,Varun Warrier,Richard A I Bethlehem et al.
Zhiqiang Sha et al.
Both psychiatric vulnerability and cortical structure are shaped by the cumulative effect of common genetic variants across the genome. However, the shared genetic underpinnings between psychiatric disorders and brain structural phenotypes,...
Shan H Siddiqi,Isaiah Kletenik,Mark C Anderson et al.
Shan H Siddiqi et al.
Depression is a common debilitating complication of multiple sclerosis (MS), but the role of lesion location remains unclear. Recent work shows that stroke lesions and therapeutic neuromodulation sites that modify depression are connected t...
P Murali Doraiswamy,Jon Andoni Duñabeitia,Carlos Rodriguez et al.
P Murali Doraiswamy et al.
Machine learning for identifying caregiving adversities associated with greatest risk for mental health problems in children [0.03%]
用于识别与儿童心理健康问题风险最大的照护不利因素的机器学习方法
Anna Vannucci,Andrea Fields,Charlotte Heleniak et al.
Anna Vannucci et al.
Developmental and experiential heterogeneity associated with caregiving-related early adversities (crEAs) poses a major challenge to identifying replicable, generalizable findings. Here conditional random forests evaluated the importance of...
Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis [0.03%]
有效连接的偏差解释了帕金森病精神病不同类型的幻觉
Miriam Vignando,Dominic Ffytche,Ndabezinhle Mazibuko et al.
Miriam Vignando et al.
Psychosis and visual hallucinations (VH) in Parkinson's disease (PD) substantially impact patient outcomes, yet the underlying neural mechanisms remain unclear, limiting effective treatments. Here we used dynamic causal modeling to leverage...
Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts [0.03%]
临床高风险队列中的大麻和烟草共用预测精神病发病
Daniel Bello,Sophia H Blyth,Rachel A Rabin et al.
Daniel Bello et al.
Cannabis and tobacco use are highly prevalent among people with psychosis and are associated with medical comorbidities and poor prognosis. Concurrent use of cannabis and tobacco ('co-use') is rising in the general population, but has not b...
The association between autistic traits and trajectories of anxiety in middle-aged and older adults: an 8-year growth mixture model analysis [0.03%]
自闭症特征与中老年人焦虑轨迹之间的联系：八年增长混合模型分析
Aphrodite Eshetu,Saloni Ghai,Anne Corbett et al.
Aphrodite Eshetu et al.
Anxiety is a highly prevalent mental health condition, and it is particularly common in autistic populations. However, little is known about its course beyond midlife in autistic populations owing to limited longitudinal research. Here we a...
Iva Ilioska,Marianne Oldehinkel,Alberto Llera et al.
Iva Ilioska et al.
Group-mean comparisons often identify atypical functional connectivity in autism, but it remains unclear whether these findings consistently manifest at the individual level. Here we use normative modeling to quantify the interindividual he...
An analysis on the role of glucagon-like peptide 1 receptor agonists in cognitive and mental health disorders [0.03%]
GLP-1受体激动剂在认知和精神疾病中作用的分析
Riccardo De Giorgi,Ana Ghenciulescu,Oliwia Dziwisz et al.
Riccardo De Giorgi et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel drugs approved for diabetes and obesity. They are acknowledged as a major scientific breakthrough. In addition to their metabolic effects, these medications act on other bodily ...
Asieh Zadbood,Yingying Tang,Wenjun Su et al.
Asieh Zadbood et al.
Pattern separation and pattern completion are opposing yet complementary components of mnemonic processing that heavily rely on the hippocampus. It has been shown that processing within the dentate gyrus (DG) subfield promotes pattern separ...