BAMOS project: osteochondral scaffold innovation applied to osteoarthritis [0.03%]
BAMOS项目：应用于骨关节炎的软骨下骨支架创新技术研究
Mario Monzón,Ricardo Donate,Chaozong Liu et al.
Mario Monzón et al.
Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles [0.03%]
无需支架的多细胞肿瘤球体的开发及其结构和代谢径向特征的空间表征
Shelby N Bess,Gaven K Smart,Matthew J Igoe et al.
Shelby N Bess et al.
Purpose: In vitro assays are essential for studying cellular biology, but traditional monolayer cultures fail to replicate the complex three-dimensional (3D) interactions of cells in living organisms. 3D culture systems o...
In vitro tools for orally inhaled drug products-state of the art for their application in pharmaceutical research and industry and regulatory challenges [0.03%]
口服吸入给药产品的体外研究工具及其在制药业和监管方面的应用和挑战
Julia Katharina Metz,Marius Hittinger,Claus-Michael Lehr
Julia Katharina Metz
The drug development process is a lengthy and expensive challenge for all involved players. Experience with the COVID-19 pandemic underlines the need for a rapid and effective approval for treatment options. As essential prerequisites for s...
Transcriptional profiling of neuronal ion channels in dorsal root ganglion-derived immortal cell line (F-11) under different culture conditions [0.03%]
不同培养条件下背根神经节衍生的永生细胞系(F-11)中神经离子通道的转录组分析
Erick Orozco Morato,Brittany Knight,Lakshmi S Nair
Erick Orozco Morato
Pathological pain is a prevalent condition that affects majority of adults with a variety of underlying disease conditions. Current available pharmacological pain treatments have several negative and potentially life-threatening side effect...
In vitro cancer models as an approach to identify targetable developmental phenotypes in cancer stem cells [0.03%]
体外癌症模型在识别癌干细胞中可靶向的发育表型方面的应用
Adrian Biddle
Adrian Biddle
Cancer therapeutics are often highly toxic to the patient, and they often elicit rapid resistance in the tumour. Recent advances have suggested a potential new way in which we may improve on this, through two important concepts: (1) that mu...
Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts [0.03%]
三维水凝胶模型在人源异种移植物传代动物实验替代中的应用
Sal Jones,Jennifer C Ashworth,Marian Meakin et al.
Sal Jones et al.
Purpose: This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike man...
Urgent action is required to increase sustainability in in vitro modelling [0.03%]
亟需采取行动以提高体外模型的可持续性
Katarina Pedersen,Anne Vanhoestenberghe,Susan Heavey
Katarina Pedersen
Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay [0.03%]
人结肠癌Caco-2细胞和单核细胞源性巨噬细胞对炎症性肠病的体外药物筛选模型价值研究
Sabrina Schnur,Vanessa Wahl,Julia K Metz et al.
Sabrina Schnur et al.
Inflammatory bowel disease (IBD) is a widespread disease, affecting a growing demographic. The treatment of chronic inflammation located in the GI-tract is dependent on the severity; therefore, the IBD treatment pyramid is commonly applied....
A novel colorimetric biosensor for detecting SARS-CoV-2 by utilizing the interaction between nucleocapsid antibody and spike proteins [0.03%]
一种利用核衣壳抗体和刺突蛋白相互作用检测SARS-CoV-2的新型比色生物传感器
Abhishek Bhattacharjee,Roberta M Sabino,Justin Gangwish et al.
Abhishek Bhattacharjee et al.
SARS-CoV-2 is a pandemic coronavirus that causes severe respiratory disease (COVID-19) in humans and is responsible for millions of deaths around the world since early 2020. The virus affects the human respiratory cells through its spike (S...
Abhishek Joshi,Arun Soni,Sanjeev Acharya
Abhishek Joshi
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition. Ulcerative colitis and Crohn's disease are types of inflammatory bowel disease. Over many decades, the disease has been a topic of study, with experts stil...