Sushmita Mishra,Murali Kumarasamy
Sushmita Mishra
Identifying and monitoring the presence of cancer metastasis and highlighting inter-and intratumoral heterogeneity is a central tenet of targeted precision oncology medicine (POM). This process of relocation of cancer cells is often referre...
Emma Rousi,Afonso Malheiro,Abhishek Harichandan et al.
Emma Rousi et al.
A 3D in vitro model of innervated skin would be a useful tool in dermatological research to study the effect of different chemicals and compounds on the sensory properties of skin. Current innervated skin models are limited in composition a...
Quantifying protrusions as tumor-specific biophysical predictors of cancer invasion in in vitro tumor micro-spheroid models [0.03%]
基于体外肿瘤微球模型定量分析作为特异性生物物理预测因子的肿瘤突起入侵癌细胞
D Caballero,A C Lima,C M Abreu et al.
D Caballero et al.
An important hallmark in cancer research is the discovery of suitable features capable to reliably predict tumor invasiveness, and consequently, their metastatic potential at an early stage. Current methods are based on molecular biomarker ...
Evaluation of calcium phosphate-coated polycaprolactone/graphene oxide scaffold with macro- and microporous structure for bone tissue engineering [0.03%]
用于骨组织工程的宏观和微观多孔结构的聚己内酯/氧化石墨烯载磷酸钙涂层支架的评价
Se Eun Kim,Na Eun Kim,Sunjae Park et al.
Se Eun Kim et al.
Objectives: This study aimed to fabricate porous PCL/GO scaffolds by adding graphene oxide (GO) which is a hydrophilic material to improve cell affinity of PCL. Calcium phosphate (CaP) coating was performed to enhance the...
Improved in vitro endothelialization on nanostructured titania with tannin/glycosaminoglycan-based polyelectrolyte multilayers [0.03%]
基于单宁/糖胺聚糖的多层聚合物可改善纳米TiO2表面内皮细胞化
Roberta M Sabino,Matt J Kipper,Alessandro F Martins et al.
Roberta M Sabino et al.
Purpose: Blood compatibility of cardiovascular implants is still a major concern. Rapid endothelialization of these implant surfaces has emerged as a promising strategy to enhance hemocompatibility and prevent complicatio...
Surface-modified WE43 magnesium alloys for reduced degradation and superior biocompatibility [0.03%]
用于降低降解和提高生物相容性的表面改性WE43镁合金
Vignesh K Manivasagam,Magesh Sankar,Caterina Bartomeu Garcia et al.
Vignesh K Manivasagam et al.
WE43 magnesium alloy was modified using surface mechanical attrition treatment (SMAT) and characterized to evaluate the influence of sub-micron surface modification on degradation rate and in vitro behavior. Modified surface was characteriz...
BAMOS project: osteochondral scaffold innovation applied to osteoarthritis [0.03%]
BAMOS项目：应用于骨关节炎的软骨下骨支架创新技术研究
Mario Monzón,Ricardo Donate,Chaozong Liu et al.
Mario Monzón et al.
Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles [0.03%]
无需支架的多细胞肿瘤球体的开发及其结构和代谢径向特征的空间表征
Shelby N Bess,Gaven K Smart,Matthew J Igoe et al.
Shelby N Bess et al.
Purpose: In vitro assays are essential for studying cellular biology, but traditional monolayer cultures fail to replicate the complex three-dimensional (3D) interactions of cells in living organisms. 3D culture systems o...
In vitro tools for orally inhaled drug products-state of the art for their application in pharmaceutical research and industry and regulatory challenges [0.03%]
口服吸入给药产品的体外研究工具及其在制药业和监管方面的应用和挑战
Julia Katharina Metz,Marius Hittinger,Claus-Michael Lehr
Julia Katharina Metz
The drug development process is a lengthy and expensive challenge for all involved players. Experience with the COVID-19 pandemic underlines the need for a rapid and effective approval for treatment options. As essential prerequisites for s...
Transcriptional profiling of neuronal ion channels in dorsal root ganglion-derived immortal cell line (F-11) under different culture conditions [0.03%]
不同培养条件下背根神经节衍生的永生细胞系(F-11)中神经离子通道的转录组分析
Erick Orozco Morato,Brittany Knight,Lakshmi S Nair
Erick Orozco Morato
Pathological pain is a prevalent condition that affects majority of adults with a variety of underlying disease conditions. Current available pharmacological pain treatments have several negative and potentially life-threatening side effect...