Alveolar epithelial-like cell differentiation in a dynamic bioreactor: a promising 3D-approach for the high-throughput generation of lung cell types from human induced pluripotent stem cells [0.03%]
一种动态生物反应器中的肺泡上皮样细胞分化：从人诱导多能干细胞高通量生成肺细胞类型的一种前景光明的三维方法
Michelle Müller,Yvonne Kohl,Anja Germann et al.
Michelle Müller et al.
Purpose: Human induced pluripotent stem cell (hiPSC)-derived lung cell types such as alveolar epithelial cells are promising for toxicological and pharmaceutical in vitro screenings. Reproducible differentiation processes...
3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response [0.03%]
三维肿瘤类球体：形态变化可反映抗肿瘤药物的药效反应
Anna Senrung,Sakshi Lalwani,Divya Janjua et al.
Anna Senrung et al.
Tumor spheroids are one of the well-characterized 3D culture systems bearing close resemblance to the physiological tissue organization and complexity of avascular solid tumor stage with hypoxic core. They hold a wide-spread application in ...
An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury risk [0.03%]
一种原始供体依赖型类器官系统用于预测特异质性药物引起的肝损伤风险
Sara Cherradi,Nicolas Taulet,Hong Tuan Duong
Sara Cherradi
One major drawback of preclinical models to test drug-induced liver injury (DILI) is their inability to predict the interindividual difference of DILI effect in a population. Consequently, a high number of molecules that passed preclinical ...
The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cells in vitro [0.03%]
有氧运动通过体外实验降低肿瘤微环境对乳腺癌细胞侵袭转移的促进作用
Marie-Juliet Brown,Matt Nickels,Elizabeth C Akam et al.
Marie-Juliet Brown et al.
Purpose: Regular exercise is known to reduce cancer risk and may prevent metastases, however, modelling this in vitro is challenging due the heterogeneity of the tumour microenvironment. Exercised serum can be used to cap...
Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks [0.03%]
缺血性卒中相关分子因素的识别与预测：差异表达基因、转录因子和蛋白质相互作用网络的整合分析
Mehran Radak,Hossein Fallahi
Mehran Radak
Ischemic stroke (IS) is a complex neurological disorder characterized by the sudden disruption of blood flow to the brain, leading to severe and often irreversible damage. Despite advances in stroke management, the underlying molecular mech...
Harvinder Singh Virk,Ketul C Popat
Harvinder Singh Virk
Titanium and its alloys are used to make different medical devices such as stents, artificial heart valves, and catheters for cardiovascular diseases due to their superior biocompatibility. Thrombus formation begins on the surface of these ...
In situ 3D spatiotemporal measurement of soluble biomarkers in spheroid culture [0.03%]
类器官球形培养液中可溶性生物标志物的原位三维时空测量方法研究
Alexander J McGhee,Eric O McGhee,Jack E Famiglietti et al.
Alexander J McGhee et al.
Background: Advanced cell culture techniques such as 3D bioprinting and hydrogel-based cell embedding techniques harbor many new and exciting opportunities to study cells in environments that closely recapitulate in vivo ...
Electrical cell-substrate impedance sensing (ECIS) as a tool to study microbial-cell interactions [0.03%]
用电阻细胞底物感应技术(E-CIS)研究微生物与细胞的相互作用
S Keerthi,A Maya Nandkumar
S Keerthi
ECIS is an impedance-based method to study the cellular responses to a stimulus. Manipulating the alternating current frequencies in ECIS helped reveal the adherent monolayer properties, including morphology, spreading, proliferation, chang...
Stainless steel and titanium alloys coated with sulfated chitosan to improve hemocompatibility properties [0.03%]
硫酸壳聚糖涂层的不锈钢和钛合金以改善血液相容性性能研究
Sandy Danielle Lucindo Gomes,Maria Rosiene Antunes Arcanjo,Francisca Raysse Mesquita Silva et al.
Sandy Danielle Lucindo Gomes et al.
The main drawbacks of blood-contacting metallic devices are corrosion and thrombus formation on the surface, so polymeric coatings have been proposed to improve its hemocompatibility. Sulfated chitosan (SC) was obtained from natural chitosa...
Longitudinally aligned inner-patterned silk fibroin conduits for peripheral nerve regeneration [0.03%]
纵向排列的内图案丝素神经导管促进外周神经再生
Ane Escobar,Mariana R Carvalho,Tiago H Silva et al.
Ane Escobar et al.
Peripheral nerve injuries represent a major clinical challenge, if nerve ends retract, there is no spontaneous regeneration, and grafts are required to proximate the nerve ends and give continuity to the nerve. The nerve guidance conduits (...