Adrian Biddle
Adrian Biddle
Harvestable tumour spheroids initiated in a gelatin-carboxymethyl cellulose hydrogel for cancer targeting and imaging with fluorescent gold nanoclusters [0.03%]
一种用于癌症靶向和荧光金纳米团簇成像的凝胶中起始并可收获的肿瘤类器官体模型
Ashkan Kamali Dashtarzheneh,Amir Afrashtehpour,Bala Subramaniyam Ramesh et al.
Ashkan Kamali Dashtarzheneh et al.
Cancer cell spheroids are the simplest 3D in vitro cancer models and have been extensively used for cancer research. More recently, models have been becoming complex, with the introduction of a matrix and non-cancer cell types to mimic spec...
Alice Scemama,Sophia Lunetto,Adrian Biddle
Alice Scemama
Whilst cancer is the single most researched disease by number of clinical trials, it remains a leading cause of death in middle- to high-income countries, with metastasis as the prime factor in cancer-associated mortality. The complex, mult...
A 3D-induced pluripotent stem cell-derived human neural culture model to study certain molecular and biochemical aspects of Alzheimer's disease [0.03%]
一种由诱导多能干细胞衍生的人类神经培养模型用于研究阿尔茨海默病的某些分子和生化方面的问题
Preeti Prasannan,Elodie Siney,Shreyasi Chatterjee et al.
Preeti Prasannan et al.
Purpose: Alzheimer's disease (AD) early pathology needs better understanding and models. Here, we describe a human induced pluripotent stem cells (iPSCs)-derived 3D neural culture model to study certain aspects of AD bioc...
Alveolar epithelial-like cell differentiation in a dynamic bioreactor: a promising 3D-approach for the high-throughput generation of lung cell types from human induced pluripotent stem cells [0.03%]
一种动态生物反应器中的肺泡上皮样细胞分化：从人诱导多能干细胞高通量生成肺细胞类型的一种前景光明的三维方法
Michelle Müller,Yvonne Kohl,Anja Germann et al.
Michelle Müller et al.
Purpose: Human induced pluripotent stem cell (hiPSC)-derived lung cell types such as alveolar epithelial cells are promising for toxicological and pharmaceutical in vitro screenings. Reproducible differentiation processes...
3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response [0.03%]
三维肿瘤类球体：形态变化可反映抗肿瘤药物的药效反应
Anna Senrung,Sakshi Lalwani,Divya Janjua et al.
Anna Senrung et al.
Tumor spheroids are one of the well-characterized 3D culture systems bearing close resemblance to the physiological tissue organization and complexity of avascular solid tumor stage with hypoxic core. They hold a wide-spread application in ...
An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury risk [0.03%]
一种原始供体依赖型类器官系统用于预测特异质性药物引起的肝损伤风险
Sara Cherradi,Nicolas Taulet,Hong Tuan Duong
Sara Cherradi
One major drawback of preclinical models to test drug-induced liver injury (DILI) is their inability to predict the interindividual difference of DILI effect in a population. Consequently, a high number of molecules that passed preclinical ...
The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cells in vitro [0.03%]
有氧运动通过体外实验降低肿瘤微环境对乳腺癌细胞侵袭转移的促进作用
Marie-Juliet Brown,Matt Nickels,Elizabeth C Akam et al.
Marie-Juliet Brown et al.
Purpose: Regular exercise is known to reduce cancer risk and may prevent metastases, however, modelling this in vitro is challenging due the heterogeneity of the tumour microenvironment. Exercised serum can be used to cap...
Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks [0.03%]
缺血性卒中相关分子因素的识别与预测：差异表达基因、转录因子和蛋白质相互作用网络的整合分析
Mehran Radak,Hossein Fallahi
Mehran Radak
Ischemic stroke (IS) is a complex neurological disorder characterized by the sudden disruption of blood flow to the brain, leading to severe and often irreversible damage. Despite advances in stroke management, the underlying molecular mech...
Harvinder Singh Virk,Ketul C Popat
Harvinder Singh Virk
Titanium and its alloys are used to make different medical devices such as stents, artificial heart valves, and catheters for cardiovascular diseases due to their superior biocompatibility. Thrombus formation begins on the surface of these ...