Adipo-on-chip: a microphysiological system to culture human mesenchymal stem cells with improved adipogenic differentiation [0.03%]
用于改善人源间充质干细胞脂肪分化培养的芯片脂肪组织微生理系统
Isisdoris Rodrigues de Souza,Andreia Akemi Suzukawa,Cintia Delai da Silva Horinouchi et al.
Isisdoris Rodrigues de Souza et al.
Obesity is associated with several comorbidities that cause high mortality rates worldwide. Thus, the study of adipose tissue (AT) has become a target of high interest because of its crucial contribution to many metabolic diseases and metab...
Hybrid additive manufacturing for Zn-Mg casting for biomedical application [0.03%]
用于生物医学应用的Zn-Mg铸造的混合增材制造技术
Kazi Safowan Shahed,Matthew Fainor,Sarah E Gullbrand et al.
Kazi Safowan Shahed et al.
Zinc (Zn) and its alloys have been the focus of recent materials and manufacturing research for orthopaedic implants due to their favorable characteristics including desirable mechanical strength, biodegradability, and biocompatibility. In ...
Ex vivo evaluation of blood coagulation on endothelial glycocalyx-inspired surfaces using thromboelastography [0.03%]
基于血管内皮糖萼层启发的表面的血凝评价
Yanyi Zang,Jessi R Vlcek,Jamie Cuchiaro et al.
Yanyi Zang et al.
Purpose: Present blood-contacting materials have not yet demonstrated to be effective in reducing blood coagulation without causing additional side effects clinically. We have developed an endothelial glycocalyx-inspired ...
A culture model for the assessment of phenylalanine neurotoxicity in phenylketonuria [0.03%]
苯酮尿症酚甘氨酸神经毒性的评价培养模型
Julian Kylies,Bianka Brunne,Gabriele M Rune
Julian Kylies
Objective: Phenylketonuria (PKU) is caused by a specific mutation of the phenylalanine hydroxylase (PAH) gene. The deficiency of PAH results in high phenylalanine levels (Phe), low tyrosine levels (Tyr), and reduced catec...
A vascularized bone-on-a-chip model development via exploring mechanical stimulation for evaluation of fracture healing therapeutics [0.03%]
一种血管化骨骼芯片模型的开发及其通过探索机械刺激来评估骨折愈合治疗的作用
Bodhisatwa Das,Sundeep V Seesala,Pallabi Pal et al.
Bodhisatwa Das et al.
Bone is the major connective tissue maintaining the structural integrity of the human body. However, fracture and many skeletal degenerative diseases can compromise this function. Thus, therapeutics related to bone degeneration are of signi...
Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models [0.03%]
骨肉瘤肿瘤微环境：开发具有生物相关性的体外三维模型的关键因素
João Rodrigues,Bruno Sarmento,Catarina Leite Pereira
João Rodrigues
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults. This type of cancer is characterized by a high mortality rate, especially for patients with resistant lung metastases. Given its low incidence, high gene...
Júlia Rodríguez-Comas,Javier Ramón-Azcón
Júlia Rodríguez-Comas
Diabetes mellitus is a significant public health problem worldwide. It encompasses a group of chronic disorders characterized by hyperglycemia, resulting from pancreatic islet dysfunction or as a consequence of insulin-producing β-cell dea...
Macro- and micro-nutrient-based multiplex stress conditions modulate in vitro tumorigenesis and aggressive behavior of breast cancer spheroids [0.03%]
基于营养和微量营养素的多重复合压力条件可调节乳腺癌球体的体外肿瘤发生及侵袭行为
Sukanya Gayan,Abhishek Teli,Anish Nair et al.
Sukanya Gayan et al.
Purpose: The aggressive nature of a tumor is presumably its inherent one, but different environmental cues can manipulate it in many ways. In this context, the influence of metabolic stresses on tumor behavior needs to be...
Advancing diagnostics and disease modeling: current concepts in biofabrication of soft microfluidic systems [0.03%]
软微流控系统的生物制造在疾病诊断和建模中的应用：当前概念及未来展望
César R Casanova,Marta R Casanova,Rui L Reis et al.
César R Casanova et al.
Soft microfluidic systems play a pivotal role in personalized medicine, particularly in in vitro diagnostics tools and disease modeling. These systems offer unprecedented precision and versatility, enabling the creation of intricate three-d...
Endothelial and smooth muscle cell interaction with hydrothermally treated titanium surfaces [0.03%]
氢thermal处理的钛表面与内皮细胞和平滑肌细胞的相互作用
Vignesh K Manivasagam,Ketul C Popat
Vignesh K Manivasagam
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, and the most common form is coronary artery disease (CAD). Treatment options include coronary artery bypass surgery (CABG) or percutaneous heart intervention (PCI),...