Organoids meet microfluidics: recent advancements, challenges, and future of organoids-on-chip [0.03%]
器官芯片中类器官的应用：最新进展、挑战及前景
Talha Chauhdari,Syeda Armana Zaidi,Jilei Su et al.
Talha Chauhdari et al.
Organoids are three-dimensional, miniaturized tissue-like structures derived from either stem cells or primary cells, emerging as powerful in vitro models for studying developmental biology, disease pathology, and drug discovery. These orga...
Pancreatic cancer extracellular vesicles stimulate Schwann cell activation and perineural invasion in vitro via IL-8/CCL2 [0.03%]
胰腺癌细胞外囊泡通过IL-8/CCL2促进雪旺氏细胞活化及体外神经周浸润
Emory Gregory,Isabel Powers,Azemat Jamshidi-Parsian et al.
Emory Gregory et al.
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths, and perineural invasion (PNI), in which cancer cells infiltrate nerves, enables metastasis in most patients. PNI is largel...
Biological characterization of breast cancer spheroid formed by fast fabrication method [0.03%]
快速制备方法构建的乳腺癌类器官体的生物学性质研究
Yuta Iijima,Norino Uenaka,Mayu Morimoto et al.
Yuta Iijima et al.
Engineered three-dimensional (3D) tissue culture platforms are useful for reproducing and elucidating complex in vivo biological phenomena. Spheroids, 3D aggregates of living cells, are produced based on physicochemical or microfabrication ...
Navigating the neuroinflammatory network: insights from diverse cell models [0.03%]
导航神经炎症网络：来自多种细胞模型的见解
Libia Catalina Salinas Castellanos,Mayra Micaela Montes,Georgina Oriana Mingolo Malnati et al.
Libia Catalina Salinas Castellanos et al.
In this Highlights article, we present insights into the use of simple cell lines in neuroinflammation research, highlighting key findings from our recent investigations. Simple cell lines, including HEK, PC12, SHSY5Y, and N2a cells, provid...
Adipo-on-chip: a microphysiological system to culture human mesenchymal stem cells with improved adipogenic differentiation [0.03%]
用于改善人源间充质干细胞脂肪分化培养的芯片脂肪组织微生理系统
Isisdoris Rodrigues de Souza,Andreia Akemi Suzukawa,Cintia Delai da Silva Horinouchi et al.
Isisdoris Rodrigues de Souza et al.
Obesity is associated with several comorbidities that cause high mortality rates worldwide. Thus, the study of adipose tissue (AT) has become a target of high interest because of its crucial contribution to many metabolic diseases and metab...
Hybrid additive manufacturing for Zn-Mg casting for biomedical application [0.03%]
用于生物医学应用的Zn-Mg铸造的混合增材制造技术
Kazi Safowan Shahed,Matthew Fainor,Sarah E Gullbrand et al.
Kazi Safowan Shahed et al.
Zinc (Zn) and its alloys have been the focus of recent materials and manufacturing research for orthopaedic implants due to their favorable characteristics including desirable mechanical strength, biodegradability, and biocompatibility. In ...
Ex vivo evaluation of blood coagulation on endothelial glycocalyx-inspired surfaces using thromboelastography [0.03%]
基于血管内皮糖萼层启发的表面的血凝评价
Yanyi Zang,Jessi R Vlcek,Jamie Cuchiaro et al.
Yanyi Zang et al.
Purpose: Present blood-contacting materials have not yet demonstrated to be effective in reducing blood coagulation without causing additional side effects clinically. We have developed an endothelial glycocalyx-inspired ...
A culture model for the assessment of phenylalanine neurotoxicity in phenylketonuria [0.03%]
苯酮尿症酚甘氨酸神经毒性的评价培养模型
Julian Kylies,Bianka Brunne,Gabriele M Rune
Julian Kylies
Objective: Phenylketonuria (PKU) is caused by a specific mutation of the phenylalanine hydroxylase (PAH) gene. The deficiency of PAH results in high phenylalanine levels (Phe), low tyrosine levels (Tyr), and reduced catec...
A vascularized bone-on-a-chip model development via exploring mechanical stimulation for evaluation of fracture healing therapeutics [0.03%]
一种血管化骨骼芯片模型的开发及其通过探索机械刺激来评估骨折愈合治疗的作用
Bodhisatwa Das,Sundeep V Seesala,Pallabi Pal et al.
Bodhisatwa Das et al.
Bone is the major connective tissue maintaining the structural integrity of the human body. However, fracture and many skeletal degenerative diseases can compromise this function. Thus, therapeutics related to bone degeneration are of signi...
Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models [0.03%]
骨肉瘤肿瘤微环境：开发具有生物相关性的体外三维模型的关键因素
João Rodrigues,Bruno Sarmento,Catarina Leite Pereira
João Rodrigues
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults. This type of cancer is characterized by a high mortality rate, especially for patients with resistant lung metastases. Given its low incidence, high gene...