3D in vitro co-culture disc for assessing cancer invasiveness in the tumor stroma microenvironment [0.03%]
一种用于评估肿瘤间质微环境中癌细胞侵袭性的三维共培养盘模型
Weiyou Sun,Yutaka Kikuchi,Haruko Takahashi
Weiyou Sun
Purpose: Cancer cell invasion into the stroma is a key step in tumor progression, yet many in vitro models fail to recapitulate stromal architecture or permit quantitative analysis along the thickness (Z) dimension. This ...
In vitro toxicity evaluation of food-grade silica nanoparticles (E551) in human digestive tract cells [0.03%]
食品级二氧化硅纳米粒子(E551)的体外毒性评估——对人体消化道细胞的影响
Beatriz Roquett,Diego Wiechers,Ana Júlia Fagundes et al.
Beatriz Roquett et al.
Synthetic amorphous silica (SAS, E551) is one of the most widely used food additives, yet uncertainties remain regarding the potential biological effects of its nanoscale fraction. In this study, we performed a metrologically aligned in vit...
Pre-clinical evaluation of mRNA-lipid nanoparticles' potency and toxicity: current practices and future directions [0.03%]
mRNA脂质纳米颗粒的药效和毒性临床前评价：现状与未来方向
Chloé Muzard,Johanne Seguin,Jonathan Bonnefoy et al.
Chloé Muzard et al.
Over the last few years, the success of COVID-19 mRNA vaccines has resulted in the emergence of RNA lipid nanoparticles (LNPs) with promising prospects for the prevention and treatment of various diseases. The context of the SARS-CoV-2 pand...
High-yield isolation of primary human hepatocytes from small liver samples [0.03%]
从小块肝脏样本中高效分离原代人肝细胞
Thea Guy,Jia-Ling Ruan,Carl Lee et al.
Thea Guy et al.
Purpose: Isolation of primary human hepatocytes (PHH) from liver specimens typically relies on the two-step perfusion method, which requires large samples, substantial resources, specialised expertise and suitable vessels...
Gellan Gum-based Bioink for Bioprinting of a Mechanically Mimetic 3D in vitro Liver Model [0.03%]
用于生物打印机械模拟的三维体外肝模型的凝胶兰生物墨水
Natália Akemi Kohori,Ibrahim Fatih Cengiz,Mariana Carvalho et al.
Natália Akemi Kohori et al.
The liver is vital for the human body's metabolism, making the development of more predictable and reproducible pathophysiological-relevant three-dimensional (3D) liver models crucial for studying the accumulation of xenobiotics and associa...
Optimization of OSCC spheroid generation for high-throughput drug screening [0.03%]
用于高通量药物筛选的OSCC类器官球体优化生成技术
Mansi Dobariya,Seena Sunil,Sai Swetha Uppalapati et al.
Mansi Dobariya et al.
Background: Three-dimensional (3D) spheroid models better replicate the in vivo tumor microenvironment than conventional two-dimensional (2D) cultures, making them valuable tools for preclinical drug screening in oral squ...
The use of three-dimensional primary human myospheres to explore skeletal muscle effects of in vivo krill oil supplementation [0.03%]
人原始三维肌肉球体的使用以探讨南极磷虾油补充对骨骼肌的影响
Andrea Dalmao-Fernandez,Parmeshwar B Katare,Hege G Bakke et al.
Andrea Dalmao-Fernandez et al.
Purpose: Supplementation with krill oil has shown effects on whole-body lipid and glucose metabolism, as well as on skeletal muscle strength and function. We previously showed that krill oil intervention in vivo promoted ...
In vitro model assesses the susceptibility of polymeric scaffolds for material-driven heart valve regeneration to calcification [0.03%]
体外模型评估多聚物支架驱动的心瓣再生钙化的敏感性
Dewy C van der Valk,Charlotte M Hoes,Yunia M H Rasenberg et al.
Dewy C van der Valk et al.
Purpose: Material driven in situ heart valve tissue engineering (HVTE) prospects an alternative to non-living replacements. HVTE exploits bioresorbable (synthetic) scaffolds that guide neo-tissue formation. Proper scaffol...
Conductive biological materials for in vitro models: properties and sustainability implications [0.03%]
用于体外模型的导电生物材料：性质及可持续性影响
Aleksandra Serafin,César R Casanova,Arvind K Singh Chandel et al.
Aleksandra Serafin et al.
The integration of conductive biological materials into in vitro models represents a transformative approach to advancing biomedical research while addressing critical sustainability challenges. Traditional materials used in tissue engineer...
Multicellular hepatic in vitro models using NANOSTACKSTM: human-relevant models for drug response prediction [0.03%]
用于药物反应预测的多细胞肝体外模型NANOSTACKSTM：具有人类相关性的模型
Abdullah C Talari,Raffaello Sbordoni,Valmira Hoti et al.
Abdullah C Talari et al.
Drug-induced liver injury (DILI) continues to be one of the leading causes of drug attrition during clinical trials, as well as the number one cause of post-market drug withdrawal due to the limited predictive accuracy of preclinical animal...