The use of three-dimensional primary human myospheres to explore skeletal muscle effects of in vivo krill oil supplementation [0.03%]
人原始三维肌肉球体的使用以探讨南极磷虾油补充对骨骼肌的影响
Andrea Dalmao-Fernandez,Parmeshwar B Katare,Hege G Bakke et al.
Andrea Dalmao-Fernandez et al.
Purpose: Supplementation with krill oil has shown effects on whole-body lipid and glucose metabolism, as well as on skeletal muscle strength and function. We previously showed that krill oil intervention in vivo promoted ...
In vitro model assesses the susceptibility of polymeric scaffolds for material-driven heart valve regeneration to calcification [0.03%]
体外模型评估多聚物支架驱动的心瓣再生钙化的敏感性
Dewy C van der Valk,Charlotte M Hoes,Yunia M H Rasenberg et al.
Dewy C van der Valk et al.
Purpose: Material driven in situ heart valve tissue engineering (HVTE) prospects an alternative to non-living replacements. HVTE exploits bioresorbable (synthetic) scaffolds that guide neo-tissue formation. Proper scaffol...
Conductive biological materials for in vitro models: properties and sustainability implications [0.03%]
用于体外模型的导电生物材料：性质及可持续性影响
Aleksandra Serafin,César R Casanova,Arvind K Singh Chandel et al.
Aleksandra Serafin et al.
The integration of conductive biological materials into in vitro models represents a transformative approach to advancing biomedical research while addressing critical sustainability challenges. Traditional materials used in tissue engineer...
Multicellular hepatic in vitro models using NANOSTACKSTM: human-relevant models for drug response prediction [0.03%]
用于药物反应预测的多细胞肝体外模型NANOSTACKSTM：具有人类相关性的模型
Abdullah C Talari,Raffaello Sbordoni,Valmira Hoti et al.
Abdullah C Talari et al.
Drug-induced liver injury (DILI) continues to be one of the leading causes of drug attrition during clinical trials, as well as the number one cause of post-market drug withdrawal due to the limited predictive accuracy of preclinical animal...
The development of a direct co-culture-based model for diabetic foot ulcer mimicking inflammation and impaired phagocytosis [0.03%]
一种模拟糖尿病足溃疡炎症和吞噬作用受损的直接共培养模型的发展
Mirella Ejiugwo,Yury Rochev,Georgina Gethin et al.
Mirella Ejiugwo et al.
Purpose: Diabetic foot ulcers (DFU) are characterized by delayed healing and high infection rates. DFU affect approximately 25% of individuals with diabetes. Secondary to hyperglycaemia, both chronic inflammation and defe...
Mechanical scratch injury on differentiated motor neuron of NSC-34 cells as an in vitro model for evaluation of neuroregeneration potential of NeuroAiD II (MLC901) [0.03%]
NSC-34细胞分化运动神经元的机械划痕损伤作为体外模型评估NeuroAid II（MLC901）神经再生潜能
Anam Anjum,Muhammad Dain Yazid,Muhammad Fauzi Daud et al.
Anam Anjum et al.
Background: Spinal cord regeneration is considered an ultimate achievement in the field of neuroscience. In vitro, neural stem cell (NSC-34) motor neuron-like cell cultures are powerful tools to study specific molecular p...
A comparative analysis of vitrification and two slow freezing methods for gonocyte-containing neonatal calf testicular tissue and subsequent in vitro culture [0.03%]
玻璃化和两种慢速冷冻方法对含有生精细胞的新生小牛睾丸组织的比较分析及其体外培养后续步骤
Shiyan Tang,Celine Jones,Jill Davies et al.
Shiyan Tang et al.
The cryopreservation of neonatal testicular tissue containing gonocytes is crucial for preserving genetic diversity, advancing research, and developing reproductive technologies. In this study, we investigated three cryopreservation techniq...
Colorectal carcinoma organoid and cancer-associated fibroblasts co-culture system for drug evaluation [0.03%]
结直肠癌类器官与癌相关成纤维细胞共培养系统在药物评估中的应用
Yan Wang,Zilin Zhang,Xiaoran Li et al.
Yan Wang et al.
Patient-derived organoids (PDO) have the potential to be used as preclinical cancer models for testing anti-cancer drug efficiency. Cancer-associated fibroblasts (CAFs), which have been closely linked with colorectal carcinoma (CRC) progres...
An in vitro model to measure the strength and stiffness of the extracellular matrix synthesized de novo by human fibroblasts [0.03%]
一种测量人类成纤维细胞从头合成的细胞外基质的力量和刚度的体外模型
Yanying Wu,Jayla Millender,Becka Padgett et al.
Yanying Wu et al.
Purpose: Alterations to the strength and stiffness of the human extracellular matrix (ECM) are the underlying pathology manifest in a wide range of diseases. These include inherited conditions, such as Ehlers Danlos syndr...
A standardized in vitro bioengineered skin for penetrating wound modeling [0.03%]
用于穿透性伤口建模的标准体外生物工程皮肤
C Sofia Salazar Silva,Werner Petzold,Ulrike Hirsch et al.
C Sofia Salazar Silva et al.
Over the years, significant progress has been made in developing cost-effective and ethical in vitro bioengineered skin substitutes to study cutaneous wound healing processes. Rodents and small animal models are not optimal due to physiolog...