3D spheroid culture to examine adaptive therapy response in invading tumor cells [0.03%]
三维球状培养技术检测侵入肿瘤细胞的适应性疗法反应
Felix Weiss,Nader Atlasy,Vince van Reijmersdal et al.
Felix Weiss et al.
3D in vitro culture models of cancer cells in extracellular matrix (ECM) have been developed to investigate drug targeting and resistance or, alternatively, mechanisms of invasion; however, models allowing analysis of shared pathways mediat...
Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases [0.03%]
牛肺芯片(bLOC)的开发与评估，用于研究牛呼吸系统疾病
Diane F Lee,Clare L Thompson,Ronald E Baynes et al.
Diane F Lee et al.
Purpose: Current air-liquid interface (ALI) models of bovine proximal airways have their limitations. They do not simulate blood flow necessary to mimic systemic drug administration, and repeated sampling requires multipl...
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems [0.03%]
昼夜节律钟蛋白BMAL-1的振荡与每日机械刺激周期对齐：在体外模型系统中整合生物时间的一种新方法
Hannah K Heywood,Laurence Gardner,Martin M Knight et al.
Hannah K Heywood et al.
Purpose: In vivo, the circadian clock drives 24-h rhythms in human physiology. Isolated cells in vitro retain a functional clockwork but lack necessary timing cues resulting in the rapid loss of tissue-level circadian rhy...
Novel application of live imaging to determine the functional cell biology of endothelial-to-mesenchymal transition (EndMT) within a liver-on-a-chip platform [0.03%]
利用活体成像技术确定芯片上的肝脏平台内内皮细胞到间充质转化（EndMT）的功能细胞生物学的新应用
James Whiteford,Samantha Arokiasamy,Clare L Thompson et al.
James Whiteford et al.
Objective: Imaging endothelial cell behaviour under physiological conditions, particularly those associated with chronic fibrotic pathologies, is an incredibly challenging endeavour. While short-term assessments (hours) c...
Lucia Iafrate,Maria Cristina Benedetti,Samantha Donsante et al.
Lucia Iafrate et al.
Bone pain typically occurs immediately following skeletal damage with mechanical distortion or rupture of nociceptive fibres. The pain mechanism is also associated with chronic pain conditions where the healing process is impaired. Any load...
Physiologically relevant platform for an advanced in vitro model of the vascular wall: focus on in situ fabrication and mechanical maturation [0.03%]
一种用于血管壁高级体外模型的生理相关平台：重点在于原位制造和机械成熟化
The mechanical stimulation applied on engineered vascular constructs in perfusion bioreactors has been shown to be beneficial for their maturation. The level of mechanical stimulation applied on these constructs depends on the flow paramete...
A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies [0.03%]
一种基于人类Caco-2共培养的发炎肠粘膜模型用于颗粒毒性研究
The intestinal barrier is a complex interface of the human body, possessing the largest contact surface to nutrients and antigens and containing a major part of the immune system. It has to deal with continuous exposure to a broad mixture o...
Development of a tissue-engineered skin model with epidermal, dermal and hypodermal components [0.03%]
一种具有表皮、真皮和皮下组织成分的组织工程皮肤模型的构建
Tissue-engineered models of skin have evolved over the past 50 years, have successfully been translated to clinical use and continue to be improved using new technologies. However, very few of these constructs incorporate a hypodermal compo...
Introducing CELLBLOKS®: a novel organ-on-a-chip platform allowing a plug-and-play approach towards building organotypic models [0.03%]
介绍CELLBLOKS®：一种新颖的器官芯片平台，可通过即插即用方法构建组织特异性模型
Human organs are structurally and functionally complex systems. Their function is driven by the interactions between many specialised cell types, which is difficult to unravel on a standard Petri dish format. Conventional "Petri dish" appro...