ECM-free lung tumoroids generated by an air-stretchable microfluidic chip [0.03%]
一种可拉伸的微流控芯片产生无基质的类器官模型用于模拟肺癌干性
Talha Chauhdari,Jilei Su,Jiabao Lv et al.
Talha Chauhdari et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide, highlighting an urgent need for improved therapeutic strategies and more physiologically relevant in vitro models to better understand lung tumor biology and accel...
Development of a functional sarcopenia model utilizing a microcantilever microphysiological system as a phenotypic disease model [0.03%]
利用微天平微生理系统作为表型疾病模型的功能性肌少症模型的开发
Himanshi Jangir,Leandro H Gallo,Russell Emmons et al.
Himanshi Jangir et al.
Purpose: Sarcopenia is a skeletal muscle (SKM) condition marked by reduced muscle mass and function and is often observed as a comorbidity with inflammatory conditions. ...
Airways-on-chip models to advance pathology treatment of respiratory organs [0.03%]
芯片集成 Airways 模型促进呼吸器官疾病病理学治疗研究
Elena Fasil,Damiano Rossi,Claudio Ricci et al.
Elena Fasil et al.
By miniaturizing functional tissue units and recreating physiological-like microenvironments with dynamic stimuli, organ-on-chip (OOC) technology has emerged as a powerful platform for in vitro disease modeling and therapeutic screening. Th...
The role of ABC transporters in the human lung epithelium-insights from and limitations of current in vitro cell models [0.03%]
ABC转运蛋白在人肺上皮中的作用-目前体外细胞模型的启示和局限性
Sina Simon,Carina Cantrill,Claus-Michael Lehr
Sina Simon
ATP-binding cassette (ABC) drug transporter proteins are expressed at the level of the human pulmonary epithelium. This protein superfamily is known to clinically affect the pharmacokinetics of their substrates in tissues such as the intest...
3D in vitro co-culture disc for assessing cancer invasiveness in the tumor stroma microenvironment [0.03%]
一种用于评估肿瘤间质微环境中癌细胞侵袭性的三维共培养盘模型
Weiyou Sun,Yutaka Kikuchi,Haruko Takahashi
Weiyou Sun
Purpose: Cancer cell invasion into the stroma is a key step in tumor progression, yet many in vitro models fail to recapitulate stromal architecture or permit quantitative analysis along the thickness (Z) dimension. This ...
In vitro toxicity evaluation of food-grade silica nanoparticles (E551) in human digestive tract cells [0.03%]
食品级二氧化硅纳米粒子(E551)的体外毒性评估——对人体消化道细胞的影响
Beatriz Roquett,Diego Wiechers,Ana Júlia Fagundes et al.
Beatriz Roquett et al.
Synthetic amorphous silica (SAS, E551) is one of the most widely used food additives, yet uncertainties remain regarding the potential biological effects of its nanoscale fraction. In this study, we performed a metrologically aligned in vit...
Pre-clinical evaluation of mRNA-lipid nanoparticles' potency and toxicity: current practices and future directions [0.03%]
mRNA脂质纳米颗粒的药效和毒性临床前评价：现状与未来方向
Chloé Muzard,Johanne Seguin,Jonathan Bonnefoy et al.
Chloé Muzard et al.
Over the last few years, the success of COVID-19 mRNA vaccines has resulted in the emergence of RNA lipid nanoparticles (LNPs) with promising prospects for the prevention and treatment of various diseases. The context of the SARS-CoV-2 pand...
High-yield isolation of primary human hepatocytes from small liver samples [0.03%]
从小块肝脏样本中高效分离原代人肝细胞
Thea Guy,Jia-Ling Ruan,Carl Lee et al.
Thea Guy et al.
Purpose: Isolation of primary human hepatocytes (PHH) from liver specimens typically relies on the two-step perfusion method, which requires large samples, substantial resources, specialised expertise and suitable vessels...
Gellan Gum-based Bioink for Bioprinting of a Mechanically Mimetic 3D in vitro Liver Model [0.03%]
用于生物打印机械模拟的三维体外肝模型的凝胶兰生物墨水
Natália Akemi Kohori,Ibrahim Fatih Cengiz,Mariana Carvalho et al.
Natália Akemi Kohori et al.
The liver is vital for the human body's metabolism, making the development of more predictable and reproducible pathophysiological-relevant three-dimensional (3D) liver models crucial for studying the accumulation of xenobiotics and associa...
Optimization of OSCC spheroid generation for high-throughput drug screening [0.03%]
用于高通量药物筛选的OSCC类器官球体优化生成技术
Mansi Dobariya,Seena Sunil,Sai Swetha Uppalapati et al.
Mansi Dobariya et al.
Background: Three-dimensional (3D) spheroid models better replicate the in vivo tumor microenvironment than conventional two-dimensional (2D) cultures, making them valuable tools for preclinical drug screening in oral squ...