A 31-year-old Woman with Painful Black Palms: Thrombosis or Vasculitis? [0.03%]
一名31岁手掌疼痛发黑的女性患者的诊断：血栓还是血管炎？
Linyi Peng,Yunyun Fei
Linyi Peng
Both of vaso-occlusive incidence of antiphospholipid syndrome (APS) or vasculitis secondary to systemic lupus erythematosus (SLE) can lead to gangrene, which requiring the urgent and appropriate therapeutic approach. However, it is sometime...
Long-term Outcomes of Patients with Systemic Lupus Erythematosus: A Multicenter Cohort Study from CSTAR Registry [0.03%]
系统性红斑狼疮患者的长期预后：CSTAR注册研究的多中心队列研究
Ziqian Wang,Mengtao Li,Zhizhong Ye et al.
Ziqian Wang et al.
Objective: To study the long-term outcomes, in the context of both mortality and organ damage in patients with systemic lupus erythematosus (SLE) in the Chinese SLE Treatment and Research group (CSTAR) registry cohort. ...
Nanoparticle-mediated Delivery of IL-2 To T Follicular Helper Cells Protects BDF1 Mice from Lupus-like Disease [0.03%]
纳米颗粒介导的IL-2递送至T滤泡辅助细胞保护BDF1小鼠免受类似狼疮疾病侵害
Concetta Ferretti,David A Horwitz,Sean Bickerton et al.
Concetta Ferretti et al.
We recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells ...
Maureen McMahon,Richard Seto,Brian J Skaggs
Maureen McMahon
There is a well-known increased risk for cardiovascular disease that contributes to morbidity and mortality in systemic lupus erythematosus (SLE). Major adverse cardiovascular events and subclinical atherosclerosis are both increased in thi...
Ram P Singh,David S Bischoff,Bevra H Hahn
Ram P Singh
T regulatory cells (Tregs) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses. Numerical and functional deficits of these c...
Recommendations on SARS-CoV-2 vaccination in adult patients with rheumatic diseases [0.03%]
风湿性疾病成人患者的SARS-CoV-2疫苗接种建议
Min Shen,Lingli Dong,Mengtao Li et al.
Min Shen et al.
Vaccination against coronavirus disease 2019 (COVID-19) has been promoted all over the world and has become an important measure to control the pandemic. Patients with rheumatic diseases are at high risk of 2019-nCoV severe infection, hence...
Interleukin-6 blocking therapy for COVID-19: From immune pathogenesis to clinical outcomes [0.03%]
从免疫病理到临床结果：阻断 interleukin-6治疗新冠肺炎
Fan Xiao,Ling Wu,Xiaoxia Zhu et al.
Fan Xiao et al.
As a newly emerged infectious disease, the coronavirus disease 2019 (COVID-19) has caused millions of deaths, resulting in a global health challenge. Currently, several vaccines have been approved with significant benefits against disease t...