Imatinib disassembles the regulatory core of Abelson kinase by binding to its ATP site and not by binding to its myristoyl pocket [0.03%]
伊马替尼通过结合阿贝尔森激酶的ATP位点而非.myristoyl口袋来分解其调控核心
Stephan Grzesiek,Johannes Paladini,Judith Habazettl et al.
Stephan Grzesiek et al.
It was recently reported (Xie et al., 2022) that the Abelson tyrosine kinase (Abl) ATP-site inhibitor imatinib also binds to Abl's myristoyl binding pocket, which is the target of allosteric Abl inhibitors. This was based on a crystal struc...
Radiation damping strongly perturbs remote resonances in the presence of homonuclear mixing [0.03%]
辐射衰减会在存在同核混频的情况下严重影响远程共振
Philippe Pelupessy
Philippe Pelupessy
In this work, it is experimentally shown that the weak oscillating magnetic field (known as the "radiation damping" field) caused by the inductive coupling between the transverse magnetization of nuclei and the radio frequency circuit pertu...
Bogdan A Rodin,Daniel Abergel
Bogdan A Rodin
Spin relaxation has been at the core of many studies since the early days of nuclear magnetic resonance (NMR) and the underlying theory worked out by its founding fathers. This Bloch-Redfield-Abraham relaxation theory has been recently rein...
Localising individual atoms of tryptophan side chains in the metallo- β-lactamase IMP-1 by pseudocontact shifts from paramagnetic lanthanoid tags at multiple sites [0.03%]
利用多个位点的参量稀土标记的伪接触偏移确定金属β-内酰胺酶IMP-1中色氨酸侧链上的单个原子的位置
Henry W Orton,Iresha D Herath,Ansis Maleckis et al.
Henry W Orton et al.
The metallo-β-lactamase IMP-1 features a flexible loop near the active site that assumes different conformations in single crystal structures, which may assist in substrate binding and enzymatic activity. To probe the position of this ...
SORDOR pulses: expansion of the Böhlen-Bodenhausen scheme for low-power broadband magnetic resonance [0.03%]
用于低功耗宽带磁共振的Böhlen-Bodenhausen方案的扩展：SORDOR脉冲序列
Jens D Haller,David L Goodwin,Burkhard Luy
Jens D Haller
A novel type of efficient broadband pulse, called second-order phase dispersion by optimised rotation (SORDOR), has recently been introduced. In contrast to adiabatic excitation, SORDOR-90 pulses provide effective transverse 90∘ rotat...
Paramagpy: software for fitting magnetic susceptibility tensors using paramagnetic effects measured in NMR spectra [0.03%]
基于NMR光谱中顺磁性效应拟合磁张量的软件:paramagpy
Henry William Orton,Thomas Huber,Gottfried Otting
Henry William Orton
Paramagnetic metal ions with fast-relaxing electrons generate pseudocontact shifts (PCSs), residual dipolar couplings (RDCs), paramagnetic relaxation enhancements (PREs) and cross-correlated relaxation (CCR) in the nuclear magnetic resonanc...
Origin of the residual line width under frequency-switched Lee-Goldburg decoupling in MAS solid-state NMR [0.03%]
频切换的Lee-Goldburg去偶下的残余线宽的来源研究——固体核磁旋转条件下
Johannes Hellwagner,Liam Grunwald,Manuel Ochsner et al.
Johannes Hellwagner et al.
Homonuclear decoupling sequences in solid-state nuclear magnetic resonance (NMR) under magic-angle spinning (MAS) show experimentally significantly larger residual line width than expected from Floquet theory to second order. We present an ...
Optimising broadband pulses for DEER depends on concentration and distance range of interest [0.03%]
宽带脉冲的优化取决于DEER的浓度和距离区间大小
Andreas Scherer,Sonja Tischlik,Sabrina Weickert et al.
Andreas Scherer et al.
EPR distance determination in the nanometre region has become an important tool for studying the structure and interaction of macromolecules. Arbitrary waveform generators (AWGs), which have recently become commercially available for EPR sp...
Distance measurement between trityl radicals by pulse dressed electron paramagnetic resonance with phase modulation [0.03%]
基于相位调制的脉冲修饰电子顺磁共振技术实现三联吡啶
Nino Wili,Henrik Hintz,Agathe Vanas et al.
Nino Wili et al.
Distance measurement in the nanometre range is among the most important applications of pulse electron paramagnetic resonance today, especially in biological applications. The longest distance that can be measured by all presently used puls...
Dieter Suter
Dieter Suter
The combination of magnetic resonance with laser spectroscopy provides some interesting options for increasing the sensitivity and information content of magnetic resonance. This review covers the basic physics behind the relevant processes...