Evgeny Nimerovsky,Kai Xue,Kumar Tekwani Movellan et al.
Evgeny Nimerovsky et al.
The radio-frequency-driven recoupling (RFDR) pulse sequence is used in magic-angle spinning (MAS) NMR to recouple homonuclear dipolar interactions. Here we show simultaneous recoupling of both the heteronuclear and homonuclear dipolar inter...
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling [0.03%]
小分子干扰蛋白Dishevelled的PDZ结构域可中断Wnt信号通路
Nestor Kamdem,Yvette Roske,Dmytro Kovalskyy et al.
Nestor Kamdem et al.
Dishevelled (Dvl) proteins are important regulators of the Wnt signalling pathway, interacting through their PDZ domains with the Wnt receptor Frizzled. Blocking the Dvl PDZ-Frizzled interaction represents a potential approach for cancer tr...
Extended Bloch-McConnell equations for mechanistic analysis of hyperpolarized 13C magnetic resonance experiments on enzyme systems [0.03%]
用于酶系统超极化碳-13磁共振实验机理分析的扩展布洛赫-麦克康奈尔方程
Thomas R Eykyn,Stuart J Elliott,Philip W Kuchel
Thomas R Eykyn
We describe an approach to formulating the kinetic master equations of the time evolution of NMR signals in reacting (bio)chemical systems. Special focus is given to studies that employ signal enhancement (hyperpolarization) methods such as...
Exclusively heteronuclear NMR experiments for the investigation of intrinsically disordered proteins: focusing on proline residues [0.03%]
用于研究固有无序蛋白的全异核磁共振实验——重点关注脯氨酸残基
Isabella C Felli,Wolfgang Bermel,Roberta Pierattelli
Isabella C Felli
NMR represents a key spectroscopic technique that contributes to the emerging field of highly flexible, intrinsically disordered proteins (IDPs) or protein regions (IDRs) that lack a stable three-dimensional structure. A set of exclusively ...
129Xe ultra-fast Z spectroscopy enables micromolar detection of biosensors on a 1 T benchtop spectrometer [0.03%]
129Xe超快Z光谱法利用台式磁体实现纳摩尔生物传感器检测
Kévin Chighine,Estelle Léonce,Céline Boutin et al.
Kévin Chighine et al.
The availability of a benchtop nuclear magnetic resonance (NMR) spectrometer, of low cost and easily transportable, can allow detection of low quantities of biosensors, provided that hyperpolarized species are used. Here we show that the mi...
Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range? [0.03%]
缓慢旋转系统中参量磁弛豫增强效应的再研究：多长的距离算长距离？
Giovanni Bellomo,Enrico Ravera,Vito Calderone et al.
Giovanni Bellomo et al.
Cross-relaxation terms in paramagnetic systems that reorient rigidly with slow tumbling times can increase the effective longitudinal relaxation rates of protons of more than 1 order of magnitude. This is evaluated by simulating the time ev...
Towards resolving the complex paramagnetic nuclear magnetic resonance (NMR) spectrum of small laccase: assignments of resonances to residue-specific nuclei [0.03%]
小漆酶复杂顺磁性核磁共振(NMR)谱的解析及特定位点共振峰归属
Rubin Dasgupta,Karthick B S S Gupta,Huub J M de Groot et al.
Rubin Dasgupta et al.
Laccases efficiently reduce dioxygen to water in an active site containing a tri-nuclear copper centre (TNC). The dynamics of the protein matrix is a determining factor in the efficiency in catalysis. To probe mobility, nuclear magnetic res...
Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics [0.03%]
核磁共振自由配体构象和原子分辨率动力学
Amber Y S Balazs,Nichola L Davies,David Longmire et al.
Amber Y S Balazs et al.
Knowledge of free ligand conformational preferences (energy minima) and conformational dynamics (rotational energy barriers) of small molecules in solution can guide drug design hypotheses and help rank ideas to bias syntheses towards more ...
Real-time nuclear magnetic resonance spectroscopy in the study of biomolecular kinetics and dynamics [0.03%]
用于生物大分子动力学和动力学研究的实时核磁共振光谱学
György Pintér,Katharina F Hohmann,J Tassilo Grün et al.
György Pintér et al.
The review describes the application of nuclear magnetic resonance (NMR) spectroscopy to study kinetics of folding, refolding and aggregation of proteins, RNA and DNA. Time-resolved NMR experiments can be conducted in a reversible or an irr...
Simple rules for resolved level-crossing spectra in magnetic field effects on reaction yields [0.03%]
磁场均化效应中resolved型交叉系谱的简化的规则
Dmitri V Stass,Victor A Bagryansky,Yuri N Molin
Dmitri V Stass
In this work we derive conditions under which a level-crossing line in a magnetic field effect curve for a recombining radical pair will be equivalent to the electron spin resonance (ESR) spectrum and discuss three simple rules for qualitat...