Unmet needs in the management of immune-mediated thrombotic thrombocytopenic purpura and the potential role of caplacizumab in the UK-A modified-Delphi study [0.03%]
英国免疫介导的血小板减少性紫癜患者的未满足需求及卡立珠单抗的潜在作用：改良德尔菲研究
Marie Scully,Tina Dutt,Will Lester et al.
Marie Scully et al.
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare, blood-clotting disorder. Management historically relies on plasma exchange and immunosuppression; however, a 10%-20% mortality rate is still observed. Caplacizumab...
Tomoyo Kubo,Yoshimitsu Shimomura,Yuya Nagai et al.
Tomoyo Kubo et al.
Inactivating BTK mutations in large B-cell lymphoma in a real-world cohort: Strong correlation with BCL2 translocation [0.03%]
中国真实世界大B细胞淋巴瘤队列中的BTK失活突变与BCL2易位的强相关性研究
Lone Schejbel,Marie Fredslund Breinholt,Anne Ortved Gang et al.
Lone Schejbel et al.
Inactivating mutations in Bruton's tyrosine kinase (BTK) in patients with follicular lymphoma (FL) have recently been reported. These mutations were found in BTK inhibitor-treatment naïve patients. Here, we report the BTK mutation status i...
Frontline polatuzumab vedotin for diffuse large B-cell lymphoma: A survey of clinician impressions [0.03%]
关于新药polatuzumab vedotin治疗弥漫性大B细胞淋巴瘤的前线用药：临床医师问卷调查结果分析
Ajay Major,Edward R Scheffer Cliff,Daniel A Ermann et al.
Ajay Major et al.
In the POLARIX trial, pola-R-CHP demonstrated improved progression-free survival (PFS) compared to R-CHOP in untreated intermediate- to high-risk DLBCL. We surveyed practicing clinicians regarding their interpretation of POLARIX, including ...
NPM1 exon 5 mutations in acute myeloid leukemia: Implications in diagnosis and minimal residual monitoring [0.03%]
急性髓系白血病中NPM1外显子5突变的诊断及微小残留监测意义研究
Peng Wang,Jeremy Segal,Michael W Drazer et al.
Peng Wang et al.
Management of acute sickle cell priapism in an African (Togo) pediatric department includes conservative measures and intracavernous epinephrine which is safe and efficacious [0.03%]
托哥儿科部门急性镰状细胞病阴茎异常勃起的管理包括保守治疗和肾上腺素灌注，安全有效
Koffi Mawuse Guedenon,Mawouto Fiawoo,Djatougbe Ayaovi Elie Akolly et al.
Koffi Mawuse Guedenon et al.
Priapism is a well-known urologic complication of sickle cell anemia. This study describes the results of a protocol for the treatment of acute priapism by intracavernous injection of epinephrine due to unavailability of etilefrine. A descr...
Management of diffuse large B-cell lymphoma with cardiac and extra-cardiac locations [0.03%]
伴有心脏和心脏外病变的弥漫性大B细胞淋巴瘤的治疗
Pauline Rottier,Pierre-Marie Morice,Mathieu Bellal
Pauline Rottier
Hematopoietic stem progenitor cells with malignancy-related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4 [0.03%]
获得性再生障碍性贫血患者中恶性相关基因突变的造血干细胞和祖细胞表现为CXCR4高表达特征
Takamasa Katagiri,Jorge Luis Espinoza,Mizuho Uemori et al.
Takamasa Katagiri et al.
The phenotypic changes in hematopoietic stem progenitor cells (HSPCs) with somatic mutations of malignancy-related genes in patients with acquired aplastic anemia (AA) are poorly understood. As our initial study showed increased CXCR4 expre...
Lymphoma-associated acquired von Willebrand syndrome responsive to splenectomy: A case report [0.03%]
脾切除治疗有效的淋巴瘤相关获得性von Willebrand综合征病例报告
Fatima Khadadah,Natasha Rupani,Jordan Scott et al.
Fatima Khadadah et al.
A previously healthy 33-year-old female presented with a large hematoma over her right knee after kneeling. She was found to have pancytopenia and massive splenomegaly. Von Willebrand Factor (VWF) antigen level was 0.38 units/ml, ristocetin...
Progressive multifocal leukoencephalopathy after durvalumab treatment for acute myeloid leukemia: A consequence of an immune reconstitution inflammatory syndrome? [0.03%]
达瓦穆班治疗急性髓系白血病后发生的进行性多灶性白质脑炎：免疫重建炎症综合征的后果？
Emeline Vinatier,Caroline Poli,Aurélien Giltat et al.
Emeline Vinatier et al.
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system resulting from the reactivation of the John Cunningham virus (JCV). PML occurs almost exclusively during profound immune suppres...