Ultrasound-Activated Biodegradable Piezoelectric Chitosan Nanoparticles for Glioblastoma Treatment [0.03%]
用于胶质母细胞瘤治疗的超声激活可降解压电壳聚糖纳米粒子
Attilio Marino,Tommaso Curiale,Marie Celine Lefevre et al.
Attilio Marino et al.
Piezoelectric nanomaterials are highly promising for remote cell stimulation due to their ability to convert mechanical energy, such as ultrasound (US), into electrical cues that modulate cellular behavior. In the context of cancer treatmen...
Actinide Nanoparticles: Revising Early Developments and Recent Insights from High-Energy-Resolution Fluorescence-Detected X-Ray Absorption Near Edge Structure and Synchrotron Techniques [0.03%]
锕系纳米颗粒：早期发展与高压射荧光检测X射线吸收近边结构和同步辐射技术的新见解
Lucia Amidani,Clara Lisa Silva,Stephan Weiss et al.
Lucia Amidani et al.
Actinide nanoparticles (NPs) are widely recognized for their role as a potentially highly mobile form of radioactive contaminants in the environment. In recent years, research has increasingly focused on elucidating their formation mechanis...
Lingli Li,Haoyu Wang,Zhiyu Wang et al.
Lingli Li et al.
Controllable thermal storage has emerged as a central theme in advanced energy management, where external stimuli such as light, stress, and pressure can be exploited to precisely regulate heat release. Yet, realizing efficient and practica...
Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation [0.03%]
调节性T细胞与纳米材料：治疗和免疫调控的双重视角
Yiyin Chen,Haibo Huang,Xiang Wang et al.
Yiyin Chen et al.
Regulatory T cells (Tregs) orchestrate immune tolerance, protecting against autoimmunity and promoting transplant tolerance, yet they can also facilitate tumor immune evasion. Advances in nanotechnology now permit high-precision manipulatio...
Chondrocyte-Targeted Nanoparticles Loaded with N-Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance [0.03%]
载有N-乙酰半胱氨酸的软骨细胞靶向型纳米颗粒通过维持谷胱甘肽抑制铁死亡从而保护关节软骨并缓解骨关节炎
Shaoyi Wang,Fujian Zhang,Xiaocong Zhou et al.
Shaoyi Wang et al.
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation. Abnormal mechanical loading exacerbates intracellular ROS accumulation and glutathione (GSH) depletion. While N-acetylcysteine (NAC) has potent anti...
Nano MiRNA-Functionating Tetrahedral Framework Nucleic Acid for Cartilage-Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis [0.03%]
纳米miRNA功能四面体框架核酸调节下颌关节铁死亡以治疗颞下颌关节炎
Wenxiu Yuan,Maotuan Huang,Linxin Chen et al.
Wenxiu Yuan et al.
Current clinical interventions lack effective strategies to arrest temporomandibular joint osteoarthritis (TMJOA) progression. Emerging evidence highlights the therapeutic potential of microRNAs (miRNAs) in osteoarthritis (OA) management, t...
Spatiotemporally Controlled Bioorthogonal Prodrug Activation for Precise Chemotherapy [0.03%]
时空可控生物正交前药激活实现精准化疗
Xia Liu,Xiao Liang,Ziqi Fang et al.
Xia Liu et al.
The uncontrolled pharmacokinetics of anticancer drugs after systemic administration can cause off-target accumulation in healthy tissues, compromising the antitumor efficacy and posing serious safety issues. To address these limitations, th...
Photoinduced Radical Cations Enable Anti-Kasha Emission in a Pyrene-Based Azacationic Ladder Polymer [0.03%]
基于吡咯烷𬭩 ladder 聚合物的抗 Kasha 发光源自光生自由基阳离子
Paulo D Nunes Barradas,Ullrich Scherf,J Sérgio Seixas de Melo
Paulo D Nunes Barradas
Conjugated ladder polymers are a unique class of macromolecules, characterized by their rigid and thermally stable structures. This work presents the synthesis and characterization of a pyrene-based azacationic ladder polymer (polymer A). S...
Unveiling the Unprecedented Optical Properties of Citrate-Stabilized Hollow AgAu Nanoshells Under Photothermal Irradiation [0.03%]
基于光热照射的柠檬酸盐稳定空心AgAu纳米壳的独特光学性质
Gregory Q Wallace,Jennifer Gracie,Amritpal Singh et al.
Gregory Q Wallace et al.
Metallic nanoshells heat efficiently on excitation of the localized surface plasmon resonance (LSPR). Whilst investigating the photothermal properties of citrate-stabilized hollow gold nanoshells (HGNs) synthesized using a sacrificial silve...
Triplet RNA Lipid Nanoparticles for Locoregional Cancer Immunotherapy [0.03%]
用于局部区域癌症免疫治疗的三链RNA脂质纳米颗粒
Adam A Walters,Yue Qin,Amer F Saleh et al.
Adam A Walters et al.
Ionizable lipid nanoparticles (LNPs) are a proven means of delivering nucleic acid-based therapeutics. This project aims to expand the LNP platform for the delivery of immunostimulatory polyinosinic-polycytidylic acid (pIpC). It is demonstr...