Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina [0.03%]
利用光遗传学方法解剖小鼠视网膜中杆体细胞输入到OFF视网膜神经节细胞的路径
Asia L Sladek,Wallace B Thoreson
Asia L Sladek
Introduction: Light responses of rod photoreceptor cells traverse the retina through three pathways. The primary pathway involves synapses from rods to ON-type rod bipolar cells with OFF signals reaching retinal ganglion ...
MURIN: Multimodal Retinal Imaging and Navigated-laser-delivery for dynamic and longitudinal tracking of photodamage in murine models [0.03%]
MURIN：用于小鼠模型光损伤的动态和纵向追踪的多模态视网膜成像和导航激光递送系统
Jose J Rico-Jimenez,Joel Jovanovic,Stephanie L Nolen et al.
Jose J Rico-Jimenez et al.
Laser-induced photodamage is a robust method for investigating retinal pathologies in small animals. However, aiming of the photocoagulation laser is often limited by manual alignment and lacks real-time feedback on lesion location and seve...
Tomomi Ichinose,Samar Habib
Tomomi Ichinose
Visual processing starts at the retina of the eye, and signals are then transferred primarily to the visual cortex and the tectum. In the retina, multiple neural networks encode different aspects of visual input, such as color and motion. S...
TLR4 signaling modulates extracellular matrix production in the lamina cribrosa [0.03%]
外周网状层基质产生受到 Toll 样受体 4信号调节的影响
Emma K Geiduschek,Paige D Milne,Philip Mzyk et al.
Emma K Geiduschek et al.
The optic nerve head (ONH) is a place of vulnerability during glaucoma progression due to increased intraocular pressure damaging the retinal ganglion cell axons. The molecular signaling pathways involved in generating glaucomatous ONH dama...
Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications [0.03%]
从临床应用角度反向翻译人工智能在青光眼中的作用：连接基础科学与临床应用
Da Ma,Louis R Pasquale,Michaël J A Girard et al.
Da Ma et al.
Artificial intelligence (AI) has been approved for biomedical research in diverse areas from bedside clinical studies to benchtop basic scientific research. For ophthalmic research, in particular glaucoma, AI applications are rapidly growin...
Evaluating the utility of deep learning for predicting therapeutic response in diabetic eye disease [0.03%]
深度学习预测糖尿病眼病治疗反应的效用评估
Vincent Dong,Duriye Damla Sevgi,Sudeshna Sil Kar et al.
Vincent Dong et al.
Purpose: Deep learning (DL) is a technique explored within ophthalmology that requires large datasets to distinguish feature representations with high diagnostic performance. There is a need for developing DL approaches t...
Bidirectional Effect of IFN-γ on Th17 Responses in Experimental Autoimmune Uveitis [0.03%]
干扰素-γ对实验性自身免疫性葡萄膜炎中Th17应答的双向调节效应
Hui Shao,Henry J Kaplan,Deming Sun
Hui Shao
Pro- and ant-inflammatory effects of IFN-γ have been repeatedly found in various immune responses, including cancer and autoimmune diseases. In a previous study we showed that the timing of treatment determines the effect of adenosine-base...
Effects of proinflammatory cytokines on lacrimal gland myoepithelial cells contraction [0.03%]
促炎症细胞因子对泪腺肌上皮细胞收缩作用的影响研究
Angela Garriz,Junji Morokuma,Maytal Bowman et al.
Angela Garriz et al.
In the lacrimal gland, myoepithelial cells (MEC) express muscle contractile proteins such as alpha smooth muscle actin (SMA) and calponin and therefore can contract to help expel lacrimal fluid. In a previous study, we demonstrated that lac...
Absence of Evidence as The Evidence Of Absence: The Curious Case of Latent Infection Causing Ocular Tuberculosis [0.03%]
无证据即反证：潜伏感染导致眼结核的蹊跷案例
Soumyava Basu
Soumyava Basu
Ocular tuberculosis (TB) is frequently considered as intraocular inflammation in the setting of latent TB, owing mainly to the absence of microbiological evidence of Mycobacterium tuberculosis in ocular fluid samples. Even though such lack ...
Axial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children [0.03%]
轴长与角膜曲率半径比值与近视儿童脉络膜血流呈负相关
Background: The pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining the interrelationships between axial length to corneal curvature radius...