Single Cell Transcriptomics Identifies Distinct Choroid Cell Populations Involved in Visually Guided Eye Growth [0.03%]
单细胞转录本组学识别与视觉引导眼睛生长有关的不同脉络膜细胞群
Jody A Summers,Kenneth L Jones
Jody A Summers
Postnatal ocular growth is regulated by a vision-dependent mechanism, termed emmetropization, which acts to minimize refractive error through coordinated growth of the ocular tissues. Many studies suggest that the ocular choroid participate...
Comparison of the extracellular vesicle proteome between glaucoma and non-glaucoma trabecular meshwork cells [0.03%]
青光眼和非青光眼小梁网细胞的胞外囊泡蛋白质组的比较研究
Fiona S McDonnell,Bre&#x;Ida J Riddick,Haven Roberts et al.
Fiona S McDonnell et al.
Introduction: Extracellular matrix (ECM) materials accumulate in the trabecular meshwork (TM) tissue of patients with glaucoma, which is associated with a decrease in aqueous humor outflow and therefore an increase in int...
Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration [0.03%]
溶血磷脂在脉络膜视网膜色素上皮脱离中占主要地位，是年龄相关性黄斑变性的高风险表型
David M G Anderson,Ankita Kotnala,Lukasz G Migas et al.
David M G Anderson et al.
Introduction: Age related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases. Extracellular deposits, including drusen and subreti...
Peripapillary Choroidal Vascularity and Visual Correlates in Non-Arteritic Anterior Ischemic Optic Neuropathy Using Swept-Source Optical Coherence Tomography [0.03%]
非动脉炎性前部缺血性视神经病变的围盘状脉络膜血管性和视觉相关性分析-采用扫频光学相干断层成像技术
Edward S Lu,Raviv Katz,John B Miller et al.
Edward S Lu et al.
Introduction: The peripapillary choroid shares a blood supply with and is directly apposed to the optic nerve, and therefore may contribute to the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NAION). ...
Alan J Emanuel,Michael Tri H Do
Alan J Emanuel
Melanopsin is a light-activated G protein coupled receptor that is expressed widely across phylogeny. In mammals, melanopsin is found in intrinsically photosensitive retinal ganglion cells (ipRGCs), which are especially important for "non-i...
Optical Coherence Tomography and Optical Coherence Tomography Angiography: Essential Tools for Detecting Glaucoma and Disease Progression [0.03%]
光学相干断层扫描和光学相干断层血管成像技术在青光眼检测及病情进展判断中的重要作用
Yukihiro Shiga,Takashi Nishida,Jin Wook Jeoung et al.
Yukihiro Shiga et al.
Early diagnosis and detection of disease progression are critical to successful therapeutic intervention in glaucoma, the leading cause of irreversible blindness worldwide. Optical coherence tomography (OCT) is a non-invasive imaging techni...
Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma [0.03%]
眼睛和视神经的星形胶质细胞：异质性群体介导轴突对青光眼的抵抗性和易损性并具有独特的功能
Paul F Cullen,Daniel Sun
Paul F Cullen
The role of glia, particularly astrocytes, in mediating the central nervous system's response to injury and neurodegenerative disease is an increasingly well studied topic. These cells perform myriad support functions under physiological co...
Syntaxin 3 is haplosufficient for long-term photoreceptor survival in the mouse retina [0.03%]
Syntaxin 3在小鼠视网膜长期间的感光细胞存活过程中足够一半剂量即可发挥作用
Mariajose Perez-Hurtado,Calvin Dao,Amanda E Saenz et al.
Mariajose Perez-Hurtado et al.
Biallelic loss-of-function mutations in the syntaxin 3 gene have been linked to a severe retinal dystrophy in humans that presents in early childhood. In mouse models, biallelic inactivation of the syntaxin 3 gene in photoreceptors rapidly ...
Pediatric cataracts of different etiologies contain insoluble, calcified particles [0.03%]
不同病因的儿童白内障包含不溶性钙化颗粒
Peter J Minogue,Sarah H Rodriguez,Viviana M Berthoud et al.
Peter J Minogue et al.
Our recent studies in mice suggest that a crucial event for the development of cataracts is the formation of calcium-containing deposits. To examine the generality of pathologic mineralization as a novel mechanism of cataract formation, we ...
miR-92a and integrin expression in fibrovascular membranes in proliferative diabetic retinopathy [0.03%]
增生性糖尿病视网膜病变纤维血管膜中miR-92a及整合素的表达
Qianyi Luo,Amir R Hajrasouliha,Ashay D Bhatwadekar
Qianyi Luo
Diabetic retinopathy (DR) is a leading cause of vision impairment. The proliferative form of DR (PDR) involves fibrovascular membrane (FVM) formation at the vitreoretinal interface. MicroRNAs (miRNAs) are a class of non-coding RNA molecules...