Initial experiences of switching to faricimab for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in an Asian population [0.03%]
法瑞西玛应用于亚洲人群特发性息肉状血管病变和年龄相关性黄斑变性的初始体验
Farah N I Ibrahim,Kelvin Y C Teo,Tien-En Tan et al.
Farah N I Ibrahim et al.
Purpose: To describe the early experiences of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) whose treatment was switched to faricimab from other anti-vascula...
Evaluation of a steroid delivery system to mitigate the severity of proliferative vitreoretinopathy in a minipig model [0.03%]
评估糖皮质激素递送系统减轻极小型猪模型增生性玻璃体视网膜病变严重程度的效果
Chee Wai Wong,Ning Cheung,James S Howden et al.
Chee Wai Wong et al.
Purpose: To investigate the efficacy of liposomal prednisolone phosphate to mitigate the severity of proliferative vitreoretinopathy (PVR) in a minipig model of PVR. ...
Characterizing the rod pathway in cone-dominated thirteen-lined ground squirrels [0.03%]
探究以视锥细胞为主的十三条纹地松鼠的棒通路特征
Riley Ferguson,Kiyoharu J Miyagishima,Francisco M Nadal-Nicolas et al.
Riley Ferguson et al.
AII-amacrine cells (AIIs) are widely accepted as a critical element of scotopic pathways mediating night vision in the mammalian retina and have been well-characterized in rod-dominant mice, rabbits, and non-human primates. The rod pathway ...
Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration [0.03%]
细胞内天冬氨酸转氨酶GOT1在视杆光受体中特异性缺失可引起视网膜退行性变mutation
Shubha Subramanya,Moloy T Goswami,Nicholas Miller et al.
Shubha Subramanya et al.
Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an underlying factor contributing to photoreceptor loss. Therefore, a comprehensive un...
A comparison of optophysiological biomarkers of photoreceptor stress and phototoxicity in BALB/cJ, B6 (Cg)-Tyrc-2J/J, and C57Bl/6J mouse strains [0.03%]
BALB/cJ、B6 (Cg)-Tyrc-2J/J和C57BL/6J小鼠品系中感光细胞应激和光毒性的光学生理生物标志物比较
Brent A Bell,Charles Kaul,Joshua L Dunaief et al.
Brent A Bell et al.
Ophthalmic imaging instruments, including the confocal scanning laser ophthalmoscope and spectral-domain optical coherence tomography system, originally intended for revealing ocular microstructures in the human eye, have been deployed by v...
Roles of transmembrane protein 135 in mitochondrial and peroxisomal functions - implications for age-related retinal disease [0.03%]
跨膜蛋白135在线粒体和过氧化物酶体功能中的作用及其对年龄相关性视网膜疾病的意义
Michael Landowski,Purnima Gogoi,Sakae Ikeda et al.
Michael Landowski et al.
Aging is the most significant risk factor for age-related diseases in general, which is true for age-related diseases in the eye including age-related macular degeneration (AMD). Therefore, in order to identify potential therapeutic targets...
Genetics of strabismus [0.03%]
斜视的遗传学研究进展
Mayra Martinez Sanchez,Mary C Whitman
Mayra Martinez Sanchez
Strabismus, or misalignment of the eyes, is the most common ocular disorder in the pediatric population, affecting approximately 2%-4% of children. Strabismus leads to the disruption of binocular vision, amblyopia, social and occupational d...
Pou4f1-Tbr1 transcriptional cascade controls the formation of Jam2-expressing retinal ganglion cells [0.03%]
Pou4f1-Tbr1转录级联控制Jam2表达视网膜神经节细胞的形成
Takae Kiyama,Halit Y Altay,Tudor C Badea et al.
Takae Kiyama et al.
More than 40 retinal ganglion cell (RGC) subtypes have been categorized in mouse based on their morphologies, functions, and molecular features. Among these diverse subtypes, orientation-selective Jam2-expressing RGCs (J-RGCs) has two uniqu...
The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats [0.03%]
内皮素受体拮抗剂macitentan改善大鼠的内皮素介导的血管收缩并促进视网膜神经节细胞存活
Bindu Kodati,Wei Zhang,Shaoqing He et al.
Bindu Kodati et al.
Glaucoma is a chronic and progressive eye disease, commonly associated with elevated intraocular pressure (IOP) and characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells (RGCs). The patholo...
Presynaptic depolarization differentially regulates dual neurotransmitter release from starburst amacrine cells in the mouse retina [0.03%]
来自小鼠网膜星形细胞的前膜去极化对双重神经递质的释放起到差异调节作用
Tomomi Ichinose,Chase B Hellmer,Jeremy M Bohl
Tomomi Ichinose
The retina is comprised of diverse neural networks, signaling from photoreceptors to ganglion cells to encode images. The synaptic connections between these retinal neurons are crucial points for information transfer; however, the input-out...