Dehydroalanine and dehydrobutyrine in aging and cataractous lenses reveal site-specific consequences of spontaneous protein degradation [0.03%]
脱水氨基酸和脱水丁氨氨基酸在老化及白内障晶状体中的位置特异性分布揭示了蛋白质自发降解的位点特异性结果
Jessica Paredes,Zhen Wang,Purvi Patel et al.
Jessica Paredes et al.
Introduction: Protein post-translational modifications (PTMs) have been associated with aging and age-related diseases. PTMs are particularly impactful in long-lived proteins, such as those found in the ocular lens, becau...
An update on immunological and molecular tests and their impact in infectious uveitis [0.03%]
免疫和分子检测在感染性葡萄膜炎中的应用及影响的新进展
Joanne Thomas,Nam V Nguyen,Tolulope Fashina et al.
Joanne Thomas et al.
Early diagnosis of infectious uveitis can lead to prompt initiation of treatment to minimize vision-threatening sequelae. As various infectious etiologies of uveitis share similar clinical features, advancements in polymerase chain reaction...
Endothelial to mesenchymal cell transition in diabetic retinopathy: targets and therapeutics [0.03%]
糖尿病视网膜病变中的内皮细胞向间充质细胞转化：靶点与治疗策略
Wasef Nijim,Mohamed Moustafa,Julia Humble et al.
Wasef Nijim et al.
Diabetic retinopathy (DR) is a result of neurovacular insults from hyperglycemia in diabetes mellitus (DM), and it is one of the top causes of vision loss throughout the modern world. This review article explores the role endothelial to mes...
MicroRNAs as potential biomarkers and therapeutic targets in age-related macular degeneration [0.03%]
微RNA可作为年龄相关性黄斑变性的生物标志物和治疗靶点
Marisa Cruz-Aguilar,Sergio Groman-Lupa,María C Jiménez-Martínez
Marisa Cruz-Aguilar
Age-related macular degeneration (AMD) involves degenerative and neovascular alteration in the macular region of the retina resulting in central vision loss. AMD can be classified into dry (dAMD) and wet AMD (wAMD). There is no established ...
Tae-Hoon Kim,Yannis M Paulus,Bernhard Baumann et al.
Tae-Hoon Kim et al.
Quantitative assessment of the choroidal vasculature in myopic macular degeneration with optical coherence tomographic angiography [0.03%]
光学相干断层扫描血管成像定量评估近视黄斑变性视网膜色素上皮下脉络膜血管生成
Yee Shan Dan,Kai Xiong Cheong,Shen Yi Lim et al.
Yee Shan Dan et al.
Background: To assess and compare choroidal morphometric vascular parameters, using optical coherence tomographic angiography (OCTA), in highly myopic adults with and without myopic macular degeneration (MMD). ...
The effects of a highly bioavailable curcumin PhytosomeTM preparation on the retinal architecture and glial reactivity in the GFAP-IL6 mice [0.03%]
一种高度生物可利用的姜黄素植物药剂对GFAP-IL6小鼠视网膜结构和胶质细胞活化的影响
Víctor Pérez-Fernández,Akshaya Lakshmi Thananjeyan,Faheem Ullah et al.
Víctor Pérez-Fernández et al.
Uncontrolled, chronic inflammation in the retina can disturb retinal structure and function leading to impaired visual function. For the first time, in a mouse model of chronic neuroinflammation (GFAP-IL6), we investigated the impact of chr...
Short-term report of early glaucoma surgery with a clear lens extraction and an intraocular lens, OMNI canaloplasty, and a HYDRUS microstent: a case series in younger patients [0.03%]
清 lens摘除和植入人工晶状体、OMNI小梁缝合术以及HYDRUS微支架的早期青光眼手术短期报告：年轻患者的病例系列
Daniel Laroche,Abelard Desrosiers,Chester Ng
Daniel Laroche
Purpose: The purpose of this case series is to report the surgical outcomes from the combination of a clear lensectomy, OMNI® canaloplasty, and a HYDRUS® microstent with an adjacent goniotomy. ...
CAR-Treg cell therapies and their future potential in treating ocular autoimmune conditions [0.03%]
CAR-Treg细胞疗法及其在未来治疗眼部自身免疫性疾病中的潜力
Alan R Abraham,Panayiotis Maghsoudlou,David A Copland et al.
Alan R Abraham et al.
Ophthalmic autoimmune and autoinflammatory conditions cause significant visual morbidity and require complex medical treatment complicated by significant side effects and lack of specificity. Regulatory T cells (Tregs) have key roles in imm...
Gene therapy for inherited retinal diseases: exploiting new tools in genome editing and nanotechnology [0.03%]
遗传性视网膜疾病的基因治疗：利用基因编辑和纳米技术的新工具
Cláudia Carvalho,Luísa Lemos,Pedro Antas et al.
Cláudia Carvalho et al.
Inherited retinal diseases (IRDs) encompass a diverse group of genetic disorders that lead to progressive visual impairment and blindness. Over the years, considerable strides have been made in understanding the underlying molecular mechani...