María C Jiménez-Martínez
María C Jiménez-Martínez
Pilot report: objective quantification of trabecular meshwork pigmentation using densitometry and the NIDEK GS-1 gonioscope in glaucoma patients [0.03%]
角膜眼前段oct联合尼德克gs-1goniopic量化色素性青光眼小梁网黑色素实验研究
Daniel Laroche,Aaron Brown,Jose Sinon et al.
Daniel Laroche et al.
In this case series, we present a methodology for a proof of principle for the development of a unique biomarker for pigmentary glaucoma to detect progression before nerve fiber layer loss. Out of the five patients in this case series, one ...
Special nuclear layer contacts between starburst amacrine cells in the mouse retina [0.03%]
小鼠视网膜中星形爆发性无长突细胞间的特殊核层接触点
Shang Mu,Nicholas L Turner,William M Silversmith et al.
Shang Mu et al.
Starburst amacrine cells are a prominent neuron type in the mammalian retina that has been well-studied for its role in direction-selective information processing. One specific property of these cells is that their dendrites tightly stratif...
Sriparna Majumdar
Sriparna Majumdar
Glutamate is an important amino acid, metabolite and excitatory neurotransmitter, which is found in its free form in the extracellular spaces of the central nervous system (CNS). More than half of all synapses in CNS release glutamate. It i...
Ocular extraintestinal manifestations and treatments in patients with inflammatory bowel disease [0.03%]
炎症性肠病患者的眼部等外周表现及治疗
Mariana Rodriguez Duran,Ghazala A Datoo O&#x;Keefe
Mariana Rodriguez Duran
Between 3-47% of patients with inflammatory bowel disease (IBD) have extraintestinal manifestations (EIMs), and between 1.3-86.9% of patients with IBD suffer from ocular EIMs (O-EIMs) making the eye the third most common organ affected. The...
Flavoprotein fluorescence elevation is a marker of mitochondrial oxidative stress in patients with retinal disease [0.03%]
黄斑疾病患者中黄素蛋白荧光升高是线粒体氧化应激的标志
Sofia Ahsanuddin,Hernan A Rios,Oscar Otero-Marquez et al.
Sofia Ahsanuddin et al.
Purpose: Recent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidat...
Biotin-cGMP and -cAMP are able to permeate through the gap junctions of some amacrine cells in the mouse retina despite their large size [0.03%]
生物素-cGMP和-cAMP可以通过小鼠视网膜某些无长突细胞的缝隙连接通道，尽管它们体积较大
Chunxu Yuan,Luca Gerhards,Ilia A Solov&#x;yov et al.
Chunxu Yuan et al.
Gap junctions transmit electrical signals in neurons and serve metabolic coupling and chemical communication. Gap junctions are made of intercellular channels with large pores, allowing ions and small molecules to permeate. In the mammalian...
Jaeyoung Yang,Jason Myers,Malcolm M Slaughter
Jaeyoung Yang
Retinal sensitivity to a variety of artificial sweeteners was tested by monitoring changes in internal free calcium in isolated retinal neurons using Fluo3. Several ligands, including aspartame and saccharin elevated internal free calcium. ...
Jeffrey Kuziel,Hannah Pope,Aishwarya J Kothapalli et al.
Jeffrey Kuziel et al.
Introduction: Nystagmus is an involuntary, conjugated, rhythmic movement of the eye that can be idiopathic or secondary to ocular or neurologic pathologies. Patients with nystagmus often have a position of gaze in which t...
The landscape of basic gene therapy approaches in inherited retinal dystrophies [0.03%]
遗传性视网膜变性疾病的基本基因治疗策略的现状与展望
Jianhua Xia,Lei Gu,Qing Pan
Jianhua Xia
The study of gene therapies has been of particular interest in recent decades due to their promising potential to slow or even rescue the degeneration of the retina in inherited retinal dystrophies (IRDs). Here, we review the current approa...