A practical guide for the generation of model-based virtual clinical trials [0.03%]
基于模型的虚拟临床试验生成实践指南
Morgan Craig,Jana L Gevertz,Irina Kareva et al.
Morgan Craig et al.
Mathematical modeling has made significant contributions to drug design, development, and optimization. Virtual clinical trials that integrate mathematical models to explore patient heterogeneity and its impact on a variety of therapeutic q...
An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal [0.03%]
一种增强型转录因子阻抑振荡器，可缓冲随机性并同步不规则外部昼夜信号
Steven A Frank
Steven A Frank
How do cellular regulatory networks solve the challenges of life? This article presents computer software to study that question, focusing on how transcription factor networks transform internal and external inputs into cellular response ou...
Pascal Laforge,Antony T Vincent,Caroline Duchaine et al.
Pascal Laforge et al.
Introduction: A thorough understanding of the microbial ecology within the swine value chain is essential to develop new strategies to optimize the microbiological quality of pork products. To our knowledge, no study to date has followed th...
Dongsheng Bai,Chenxu Zhu
Dongsheng Bai
The recent surge in single-cell genomics, including the development of a wide range of experimental and computational approaches, has provided insights into the complex molecular networks of cells during development and in human diseases at...
Application of machine learning in combination with mechanistic modeling to predict plasma exposure of small molecules [0.03%]
机器学习与机制建模相结合预测小分子暴露量的方法及其应用
Panteleimon D Mavroudis,Donato Teutonico,Alexandra Abos et al.
Panteleimon D Mavroudis et al.
Prediction of a new molecule's exposure in plasma is a critical first step toward understanding its efficacy/toxicity profile and concluding whether it is a possible first-in-class, best-in-class candidate. For this prediction, traditional ...
Mapping out the gut microbiota-dependent trimethylamine N-oxide super pathway for systems biology applications [0.03%]
绘制系统生物学研究中的肠道菌群依赖性的三甲胺N氧化物超级通路地图
Isabel M E Valenbreder,Sonia Balăn,Marian Breuer et al.
Isabel M E Valenbreder et al.
The metabolic axis linking the gut microbiome and heart is increasingly being researched in the context of cardiovascular health. The gut microbiota-derived trimethylamine/trimethylamine N-oxide (TMA/TMAO) pathway is responsible along this ...
Editorial: Systems biology, women in science 2021/22: translational systems biology and in silico trials [0.03%]
主编评论：系统生物学、2021/22年度女性科学家增刊：转化型系统生物学和计算机模拟临床试验
Jane A Leopold,Madhavi K Ganapathiraju,Naveena Yanamala
Jane A Leopold
Shawn A Means,Md A Ali,Harvey Ho
Shawn A Means
Unfortunately for the estimated 250 million sufferers of chronic hepatitis-B viral (HBV) infection worldwide, the liver terrain is typically ignored. An immuno-tolerant environment attractive for pathogens, the essential metabolic roles and...
Fine tuning a logical model of cancer cells to predict drug synergies: combining manual curation and automated parameterization [0.03%]
通过结合手动校对和自动化参数化精细调整癌细胞的逻辑模型以预测药物协同作用
Åsmund Flobak,John Zobolas,Miguel Vazquez et al.
Åsmund Flobak et al.
Treatment with combinations of drugs carries great promise for personalized therapy for a variety of diseases. We have previously shown that synergistic combinations of cancer signaling inhibitors can be identified based on a logical framew...
Network motifs and hypermotifs in TGFβ-induced epithelial to mesenchymal transition and metastasis [0.03%]
TGFβ诱导的上皮间质转化和转移过程中的网络模式及超模式
Gottumukkala Sai Bhavani,Anbumathi Palanisamy
Gottumukkala Sai Bhavani
Epithelial to mesenchymal transition (EMT) is a complex, non-linear, dynamic multistep process that plays an integral role in the development of metastatic cancers. A diverse range of signaling molecules, along with their associated pathway...