Interplay of circular RNAs in gastric cancer - a systematic review [0.03%]
胃癌中 Circular RNA 的相互作用-系统综述研究
Dipanjan Guha,Jit Mondal,Anirban Nandy et al.
Dipanjan Guha et al.
Circular RNAs (circRNAs) have gained prominence as important players in various biological processes such as gastric cancer (GC). Identification of several dysregulated circRNAs may serve as biomarkers for early diagnosis or as novel therap...
Zeyuan Song,Sophia Gunn,Stefano Monti et al.
Zeyuan Song et al.
Gaussian Graphical Models (GGMs) are a type of network modeling that uses partial correlation rather than correlation for representing complex relationships among multiple variables. The advantage of using partial correlation is to show the...
A microbiota-epigenetic circuit controls systematic circadian programs in the gut epithelium [0.03%]
微生物表观遗传回路控制肠道上皮的系统性昼夜节律程序
Junjie Ma,Jianglin Zhang,Zheng Kuang
Junjie Ma
The intestinal microbiota is an important factor that regulates mammalian circadian rhythms and health. We previously reported that the microbiota synchronizes lipid uptake and metabolism in the intestinal epithelium through histone deacety...
Penny Nymark,Laure-Alix Clerbaux,Maria-João Amorim et al.
Penny Nymark et al.
The COVID-19 pandemic generated large amounts of data on the disease pathogenesis leading to a need for organizing the vast knowledge in a succinct manner. Between April 2020 and February 2023, the CIAO consortium exploited the Adverse Outc...
A review of mathematical modeling of bone remodeling from a systems biology perspective [0.03%]
从系统生物学角度审视骨重建的数学模型综述
Carley V Cook,Ariel M Lighty,Brenda J Smith et al.
Carley V Cook et al.
Bone remodeling is an essential, delicately balanced physiological process of coordinated activity of bone cells that remove and deposit new bone tissue in the adult skeleton. Due to the complex nature of this process, many mathematical mod...
A robust ensemble feature selection approach to prioritize genes associated with survival outcome in high-dimensional gene expression data [0.03%]
一种稳健的集成特征选择方法，用于在高维基因表达数据中优先处理与生存结果相关的基因
Phi Le,Xingyue Gong,Leah Ung et al.
Phi Le et al.
Exploring features associated with the clinical outcome of interest is a rapidly advancing area of research. However, with contemporary sequencing technologies capable of identifying over thousands of genes per sample, there is a challenge ...
Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease [0.03%]
预测高血压慢性肾病的非洲美国人群对钙通道阻滞剂的慢性反应虚拟群体研究
John S Clemmer,W Andrew Pruett,Robert L Hester
John S Clemmer
Chronic kidney disease (CKD) is associated with the progressive loss of functional nephrons and hypertension (HTN). Clinical studies demonstrate calcium channel blocker (CCB) therapy mitigates the decline in renal function in humans with es...
A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons [0.03%]
多尺度干预建模框架：虚拟队列、虚拟临床试验及模型间比较
Christian T Michael,Sayed Ahmad Almohri,Jennifer J Linderman et al.
Christian T Michael et al.
Computational models of disease progression have been constructed for a myriad of pathologies. Typically, the conceptual implementation for pathology-related in-silico intervention studies has been ad-hoc and similar in design to experiment...
A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration [0.03%]
完整的人体微生物组指南：生境、传播、发育、失调与恢复疗法
Jelissa Reynoso-García,Angel E Miranda-Santiago,Natalie M Meléndez-Vázquez et al.
Jelissa Reynoso-García et al.
Humans are supra-organisms co-evolved with microbial communities (Prokaryotic and Eukaryotic), named the microbiome. These microbiomes supply essential ecosystem services that play critical roles in human health. A loss of indigenous microb...
Crosstalking with Dendritic Cells: A Path to Engineer Advanced T Cell Immunotherapy [0.03%]
与树突细胞相互作用：工程化先进T细胞免疫疗法之路
Sogand Schafer,Kaige Chen,Leyuan Ma
Sogand Schafer
Crosstalk between dendritic cells (DCs) and T cells plays a crucial role in modulating immune responses in natural and pathological conditions. DC-T cell crosstalk is achieved through contact-dependent (i.e., immunological synapse) and cont...