Probing microdomain Ca2+ activity and synaptic transmission with a node-based tripartite synapse model [0.03%]
基于节点的三元突触模型探究微域钙离子浓度与突触传递之间的关系
Langzhou Liu,Huayi Gao,Jinyu Li et al.
Langzhou Liu et al.
Astrocytic fine processes are the most minor structures of astrocytes but host much of the Ca2+ activity. These localized Ca2+ signals spatially restricted to microdomains are crucial for information processing and synaptic transmission. Ho...
Sleep staging in the ICU with heart rate variability and breathing signals. An exploratory cross-sectional study using deep neural networks [0.03%]
基于深度神经网络的心率变异性及呼吸信号在ICU中的睡眠分期研究探索性横断面研究
Wolfgang Ganglberger,Parimala Velpula Krishnamurthy,Syed A Quadri et al.
Wolfgang Ganglberger et al.
Introduction: To measure sleep in the intensive care unit (ICU), full polysomnography is impractical, while activity monitoring and subjective assessments are severely confounded. However, sleep is an intensely networked state, and reflecte...
Measuring pain and nociception: Through the glasses of a computational scientist. Transdisciplinary overview of methods [0.03%]
疼痛和伤害性刺激的测量：计算科学家视角下的跨学科方法综述
Ekaterina Kutafina,Susanne Becker,Barbara Namer
Ekaterina Kutafina
In a healthy state, pain plays an important role in natural biofeedback loops and helps to detect and prevent potentially harmful stimuli and situations. However, pain can become chronic and as such a pathological condition, losing its info...
Predicting alveolar ventilation heterogeneity in pulmonary fibrosis using a non-uniform polyhedral spring network model [0.03%]
使用非均匀多面体弹簧网络模型预测肺纤维化中的肺泡通气异质性
Joseph K Hall,Jason H T Bates,Dylan T Casey et al.
Joseph K Hall et al.
Pulmonary Fibrosis (PF) is a deadly disease that has limited treatment options and is caused by excessive deposition and cross-linking of collagen leading to stiffening of the lung parenchyma. The link between lung structure and function in...
Neuron arbor geometry is sensitive to the limited-range fractal properties of their dendrites [0.03%]
神经元树突的分形特性对其几何结构有重要影响
Conor Rowland,Julian H Smith,Saba Moslehi et al.
Conor Rowland et al.
Fractal geometry is a well-known model for capturing the multi-scaled complexity of many natural objects. By analyzing three-dimensional images of pyramidal neurons in the rat hippocampus CA1 region, we examine how the individual dendrites ...
Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes [0.03%]
不同兴奋/抑制平衡条件下共振神经元网络的异质同步机制研究
Jiaxing Wu,Sara J Aton,Victoria Booth et al.
Jiaxing Wu et al.
Rhythmic synchronization of neuronal firing patterns is a widely present phenomenon in the brain-one that seems to be essential for many cognitive processes. A variety of mechanisms contribute to generation and synchronization of network os...
Michiel van der Vlag,Marmaduke Woodman,Jan Fousek et al.
Michiel van der Vlag et al.
Whole brain network models are now an established tool in scientific and clinical research, however their use in a larger workflow still adds significant informatics complexity. We propose a tool, RateML, that enables users to generate such...
Emergent Diversity and Persistent Turnover in Evolving Microbial Cross-Feeding Networks [0.03%]
微生物互养网络进化中的多样性和持续性变化
Leonhard Lücken,Sinikka T Lennartz,Jule Froehlich et al.
Leonhard Lücken et al.
A distinguishing feature of many ecological networks in the microbial realm is the diversity of substrates that could potentially serve as energy sources for microbial consumers. The microorganisms are themselves the agents of compound dive...
Generalized Net Model of the Foreign Object Principle and its Network Physiology Interpretations [0.03%]
foreign object原理的广义net模型及其网络生理学解释
Krassimir Atanassov,Galya Staneva,Tania Pencheva
Krassimir Atanassov
The Foreign Object Principle has been introduced in a formalized form for first time. Proven as a suitable tool for modelling of parallel processes flowing in real time, the generalized nets have been used for an interpretation of the Forei...
Long-Lasting Desynchronization of Plastic Neuronal Networks by Double-Random Coordinated Reset Stimulation [0.03%]
双随机协调重置刺激使塑料神经网络长时间脱同步化
Ali Khaledi-Nasab,Justus A Kromer,Peter A Tass
Ali Khaledi-Nasab
Hypersynchrony of neuronal activity is associated with several neurological disorders, including essential tremor and Parkinson's disease (PD). Chronic high-frequency deep brain stimulation (HF DBS) is the standard of care for medically ref...