Bloodmeal host identities among sympatric Glossina austeni and Glossina pallidipes tsetse flies in Shimba Hills National Reserve, Kwale, Kenya [0.03%]
肯尼亚夸勒希姆巴山区国家保护区共生的Glossina austeni和Glossina pallidipes采血宿主的身份识别
Kennedy O Ogolla,Tevin Onyango,Billiah K Bwana et al.
Kennedy O Ogolla et al.
Odor from preferred/non-preferred tsetse fly vertebrate hosts have been exploited in R&D of attractants/repellents of the fly for human and livestock protection. Odors from vertebrate hosts of Glossina austeni and Glossina pallidipes tsetse...
Limited genetic variations of the Rh5-CyRPA-Ripr invasion complex in Plasmodium falciparum parasite population in selected malaria-endemic regions, Kenya [0.03%]
肯尼亚疟疾流行地区Plasmodium falciparum寄生虫群中Rh5-CyRPA-Ripr入侵复合体的有限遗传变异
Harrison Waweru,Bernard N Kanoi,Josiah O Kuja et al.
Harrison Waweru et al.
The invasion of human erythrocytes by Plasmodium falciparum merozoites requires interaction between parasite ligands and host receptors. Interaction of PfRh5-CyRPA-Ripr protein complex with basigin, an erythrocyte surface receptor, via PfRh...
Evaluating the Mating Competency of Genetically Modified Male Mosquitoes in Laboratory Conditions [0.03%]
转基因雄蚊交配竞争力的实验室评价研究
Bryan Contreras,Zach N Adelman,Keun Chae
Bryan Contreras
Efforts to eradicate mosquito-borne diseases have increased the demand for genetic control strategies, many of which involve the release of genetically modified (GM) mosquito males into natural populations. The first hurdle for GM males is ...
Live-Attenuated VEEV Vaccine Delivered by iDNA Using Microneedles Is Immunogenic in Rabbits [0.03%]
使用微针递送的iDNA载体活减毒VEEV疫苗可诱导兔产生免疫反应
Irina Tretyakova,Mark Tomai,John Vasilakos et al.
Irina Tretyakova et al.
Effective and simple delivery of DNA vaccines remains a key to successful clinical applications. Previously, we developed a novel class of DNA vaccines, sometimes called iDNA, which encodes the whole live-attenuated vaccine viruses. Compare...
Ching-Wen Chen,E Ashley Moseman
Ching-Wen Chen
Naegleria fowleri, or the "brain-eating amoeba," is responsible for a rare, but lethal, infection known as primary amoebic meningoencephalitis (PAM). Confirmed PAM cases have seen both a rise in numbers, as well as expansion of geographic r...
Adjuvants Differentially Modulate the Immunogenicity of Lassa Virus Glycoprotein Subunits in Mice [0.03%]
不同的免疫佐剂通过调节糖蛋白亚基的免疫原性来差异化地影响LASV在小鼠体内的致病性
Albert To,Chih-Yun Lai,Teri Ann S Wong et al.
Albert To et al.
Lassa Fever (LF) is an acute viral hemorrhagic fever caused by Lassa virus (LASV) that is primarily transmitted through contact with wild rodents in West Africa. Although several advanced vaccine candidates are progressing through clinical ...
Analysis of key genes in Mycobacterium ulcerans reveals conserved RNA structural motifs and regions with apparent pressure to remain unstructured [0.03%]
结核分枝杆菌溃疡亚种关键基因分析发现保守的RNA结构基元及保持非结构化的区域
Warren B Rouse,Jessica Gart,Lauren Peysakhova et al.
Warren B Rouse et al.
Buruli Ulcer is a neglected tropical disease that results in disfiguring and dangerous lesions in affected persons across a wide geographic area, including much of West Africa. The causative agent of Buruli Ulcer is Mycobacterium ulcerans, ...
Implementing a One Health Approach to Rabies Surveillance: Lessons From Integrated Bite Case Management [0.03%]
迈向健康方法的狂犬病监测：综合咬伤病例管理的经验教训
Catherine Swedberg,Stella Mazeri,Richard J Mellanby et al.
Catherine Swedberg et al.
As part of the 'Zero by 30' strategy to end human deaths from dog-mediated rabies by 2030, international organizations recommend a One Health framework that includes Integrated Bite Case Management (IBCM). However, little is understood abou...
Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection [0.03%]
发现一类具有抗沙眼衣原体感染活性的吡唑并吡咯酮类化合物
John A Kavouris,Laura-Isobel McCall,Miriam A Giardini et al.
John A Kavouris et al.
Introduction: Leishmaniasis is a parasitic disease that affects more than 1 million people worldwide annually, predominantly in resource-limited settings. The challenge in compound development is to exhibit potent activit...
Bio-products from Serratia marcescens isolated from Ghanaian Anopheles gambiae reduce Plasmodium falciparum burden in vector mosquitoes [0.03%]
从加纳按蚊中分离的产红质色杆菌对疟疾感染的影响研究
Esinam Abla Akorli,Prince Chigozirim Ubiaru,Sabyasachi Pradhan et al.
Esinam Abla Akorli et al.
Novel ideas for control of mosquito-borne disease include the use of bacterial symbionts to reduce transmission. Bacteria belonging to the family Enterobacteriaceae isolated from mosquito midgut have shown promise in limiting Plasmodium int...