Volatile Organic Compounds Produced by Human Pathogenic Fungi Are Toxic to Drosophila melanogaster [0.03%]
致病真菌产生的挥发性有机化合物对果蝇具有毒性
Hadeel S Almaliki,Astrid Angela,Nayab J Goraya et al.
Hadeel S Almaliki et al.
Volatile organic compounds (VOCs) are low molecular mass organic compounds that easily evaporate at room temperature. Fungi produce diverse mixtures of VOCs, some of which may contribute to "sick building syndrome," and which have been show...
DNA Methylation Is Responsive to the Environment and Regulates the Expression of Biosynthetic Gene Clusters, Metabolite Production, and Virulence in Fusarium graminearum [0.03%]
稻瘟线虫分泌效应蛋白FTL1诱导宿主靶标蛋白激酶FMK1的活化以促进病原体感染
Christopher Bonner,Amanda Sproule,Owen Rowland et al.
Christopher Bonner et al.
Histone modifications play a significant role in the regulation of biosynthetic gene clusters (BGCs) in the phytopathogen Fusarium graminearum, by contrast, epigenetic regulation by DNA methyltransferases (DNMTs) is less documented. In this...
Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates of Aspergillus fumigatus [0.03%]
伊曲康唑敏感表型的全基因组关联分析及其在烟管孢霉临床分离株中的应用
Shu Zhao,Wenbo Ge,Akira Watanabe et al.
Shu Zhao et al.
Aspergillus fumigatus is a potentially lethal opportunistic pathogen that infects over ~200,000 people and causes ~100,000 deaths per year globally. Treating A. fumigatus infections is particularly challenging because of the recent emergenc...
Scott E Baker
Scott E Baker
Gustavo Henrique Goldman
Gustavo Henrique Goldman
Toni Gabaldón
Toni Gabaldón
Cell wall composition in Cryptococcus neoformans is media dependent and alters host response, inducing protective immunity [0.03%]
新型隐球菌的细胞壁成分受培养基影响，并能改变宿主反应，诱导保护性免疫
Rajendra Upadhya,Woei C Lam,Camaron R Hole et al.
Rajendra Upadhya et al.
Introduction: Cryptococcus neoformans is a basidiomycete fungus that can cause meningoencephalitis, especially in immunocompromised patients. Cryptococcus grows in many different media, although little attention has been ...
When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ß(1,3)-Glucan Exposure in Candida albicans [0.03%]
什么时候卸下面具？调节白色念珠菌β-（1,3）-糖露的信号通路
Tian Chen,Andrew S Wagner,Todd B Reynolds
Tian Chen
Candida spp. are an important source of systemic and mucosal infections in immune compromised populations. However, drug resistance or toxicity has put limits on the efficacy of current antifungals. The C. albicans cell wall is considered a...
Extensive non-coding sequence divergence between the major human pathogen Aspergillus fumigatus and its relatives [0.03%]
烟曲霉与其近缘物种的非编码区序列广泛差异性分析
Alec Brown,Matthew E Mead,Jacob L Steenwyk et al.
Alec Brown et al.
Invasive aspergillosis is a deadly fungal disease; more than 400,000 patients are infected worldwide each year and the mortality rate can be as high as 50-95%. Of the ~450 species in the genus Aspergillus only a few are known to be clinical...
A Conserved Gcn2-Gcn4 Axis Links Methionine Utilization and the Oxidative Stress Response in Cryptococcus neoformans [0.03%]
Cryptococcus neoformans中保守的Gcn2-Gcn4轴连接蛋氨酸利用和氧化应激反应
Anna K Stovall,Corey M Knowles,Murat C Kalem et al.
Anna K Stovall et al.
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of gene regulation to adapt to stressors it encounters in the human host, such as oxidative stress and nutrient limitation. The kinase Gcn2 regulates tran...